{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T13:08:28Z","timestamp":1786799308201,"version":"build-2736575974"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>The posterior circulation Acute Stroke Prognosis Early CT Score (pc-ASPECTS) quantifies the extent of early ischemic changes in the posterior circulation with a 10-point grading system. We hypothesized that pc-ASPECTS applied to CT angiography source images predicts functional outcome of patients in the Basilar Artery International Cooperation Study (BASICS).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>BASICS was a prospective, observational registry of consecutive patients with acute symptomatic basilar artery occlusion. Functional outcome was assessed at 1 month. We applied pc-ASPECTS to CT angiography source images of patients with CT angiography for confirmation of basilar artery occlusion. We calculated unadjusted and adjusted risk ratios (RRs) of pc-ASPECTS dichotomized at \u22658 versus &lt;8. Primary outcome measure was favorable outcome (modified Rankin Scale scores 0\u20133). Secondary outcome measures were mortality and functional independence (modified Rankin Scale scores 0\u20132).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>Of 158 patients included, 78 patients had a CT angiography source images pc-ASPECTS \u22658. Patients with a pc-ASPECTS \u22658 more often had a favorable outcome than patients with a pc-ASPECTS &lt;8 (crude RR, 1.7; 95% CI, 0.98\u20133.0). After adjustment for age, baseline National Institutes of Health Stroke Scale score, and thrombolysis, pc-ASPECTS \u22658 was not related to favorable outcome (RR, 1.3; 95% CI, 0.8\u20132.2), but it was related to reduced mortality (RR, 0.7; 95% CI, 0.5\u20130.98) and functional independence (RR, 2.0; 95% CI, 1.1\u20133.8). In post hoc analysis, pc-ASPECTS dichotomized at \u22656 versus &lt;6 predicted a favorable outcome (adjusted RR, 3.1; 95% CI, 1.2\u20137.5).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>pc-ASPECTS on CT angiography source images independently predicted death and functional independence at 1 month in the CT angiography subgroup of patients in the BASICS registry.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.111.622175","type":"journal-article","created":{"date-parts":[[2011,9,30]],"date-time":"2011-09-30T11:52:01Z","timestamp":1317383521000},"page":"3454-3459","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":111,"title":["Extent of Hypoattenuation on CT Angiography Source Images in Basilar Artery Occlusion"],"prefix":"10.1161","volume":"42","author":[{"given":"Volker","family":"Puetz","sequence":"first","affiliation":[{"name":"From St Antonius Hospital Nieuwegein (W.J.S., E.v.d.H.), Nieuwegein, The Netherlands; the Utrecht Stroke Center (L.J.K., A.A.), Utrecht, The Netherlands; the Julius Center for Health Sciences and Primary Care (A.A.), Utrecht, The Netherlands; the University of Bern (H.P.M., M.A.), Bern, Switzerland; University Hospital Basel (S.T.E., S.W.), Basel, Switzerland; Centre Hospitalier Universitaire Vaudois Lausanne (P.M.), Lausanne, Switzerland; Dresden University Stroke Center (V.P., A.K., I.D., R.v.K.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Khomenko","sequence":"additional","affiliation":[{"name":"From St Antonius Hospital Nieuwegein (W.J.S., E.v.d.H.), Nieuwegein, The Netherlands; the Utrecht Stroke Center (L.J.K., A.A.), Utrecht, The Netherlands; the Julius Center for Health Sciences and Primary Care (A.A.), Utrecht, The Netherlands; the University of Bern (H.P.M., M.A.), Bern, Switzerland; University Hospital Basel (S.T.E., S.W.), Basel, Switzerland; Centre Hospitalier Universitaire Vaudois Lausanne (P.M.), Lausanne, Switzerland; Dresden University Stroke Center (V.P., A.K., I.D., R.v.K.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Hill","sequence":"additional","affiliation":[{"name":"From St Antonius Hospital Nieuwegein (W.J.S., E.v.d.H.), Nieuwegein, The Netherlands; the Utrecht Stroke Center (L.J.K., A.A.), Utrecht, The Netherlands; the Julius Center for Health Sciences and Primary Care (A.A.), Utrecht, The Netherlands; the University of Bern (H.P.M., M.A.), Bern, Switzerland; University Hospital Basel (S.T.E., S.W.), Basel, Switzerland; Centre Hospitalier Universitaire Vaudois Lausanne (P.M.), Lausanne, Switzerland; Dresden University Stroke Center (V.P., A.K., I.D., R.v.K.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imanuel","family":"Dzialowski","sequence":"additional","affiliation":[{"name":"From St Antonius Hospital Nieuwegein (W.J.S., E.v.d.H.), Nieuwegein, The Netherlands; the Utrecht Stroke Center (L.J.K., A.A.), Utrecht, The Netherlands; the Julius Center for Health Sciences and Primary Care (A.A.), Utrecht, The Netherlands; the University of Bern (H.P.M., M.A.), Bern, Switzerland; University Hospital Basel (S.T.E., S.W.), Basel, Switzerland; Centre Hospitalier Universitaire Vaudois Lausanne (P.M.), Lausanne, Switzerland; Dresden University Stroke Center (V.P., A.K., I.D., R.v.K.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Michel","sequence":"additional","affiliation":[{"name":"From St Antonius Hospital Nieuwegein (W.J.S., E.v.d.H.), Nieuwegein, The Netherlands; the Utrecht Stroke Center (L.J.K., A.A.), Utrecht, The Netherlands; the Julius Center for Health Sciences and Primary Care (A.A.), Utrecht, The Netherlands; the University of Bern (H.P.M., M.A.), Bern, Switzerland; University Hospital Basel (S.T.E., S.W.), Basel, Switzerland; Centre Hospitalier Universitaire Vaudois Lausanne (P.M.), Lausanne, Switzerland; Dresden University Stroke Center (V.P., A.K., I.D., R.v.K.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Weimar","sequence":"additional","affiliation":[{"name":"From St Antonius Hospital Nieuwegein (W.J.S., E.v.d.H.), Nieuwegein, The Netherlands; the Utrecht Stroke Center (L.J.K., A.A.), Utrecht, The Netherlands; the Julius Center for Health Sciences and Primary Care (A.A.), Utrecht, The Netherlands; the University of Bern (H.P.M., M.A.), Bern, Switzerland; University Hospital Basel (S.T.E., S.W.), Basel, Switzerland; Centre Hospitalier Universitaire Vaudois Lausanne (P.M.), Lausanne, Switzerland; Dresden University Stroke Center (V.P., A.K., I.D., R.v.K.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A.C.","family":"Wijman","sequence":"additional","affiliation":[{"name":"From St Antonius Hospital Nieuwegein (W.J.S., E.v.d.H.), Nieuwegein, The Netherlands; the Utrecht Stroke Center (L.J.K., A.A.), Utrecht, The Netherlands; the Julius Center for Health Sciences and Primary Care (A.A.), Utrecht, The Netherlands; the University of Bern (H.P.M., M.A.), Bern, Switzerland; University Hospital Basel (S.T.E., S.W.), Basel, Switzerland; Centre Hospitalier Universitaire Vaudois Lausanne (P.M.), Lausanne, Switzerland; Dresden University Stroke Center (V.P., A.K., I.D., R.v.K.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich P.","family":"Mattle","sequence":"additional","affiliation":[{"name":"From St Antonius Hospital Nieuwegein (W.J.S., E.v.d.H.), Nieuwegein, The Netherlands; the Utrecht Stroke Center (L.J.K., A.A.), Utrecht, The Netherlands; the Julius Center for Health Sciences and Primary Care (A.A.), Utrecht, The Netherlands; the University of Bern (H.P.M., M.A.), Bern, Switzerland; University Hospital Basel (S.T.E., S.W.), Basel, Switzerland; Centre Hospitalier Universitaire Vaudois Lausanne (P.M.), Lausanne, Switzerland; Dresden University Stroke Center (V.P., A.K., I.D., R.v.K.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan T.","family":"Engelter","sequence":"additional","affiliation":[{"name":"From St Antonius Hospital Nieuwegein (W.J.S., E.v.d.H.), Nieuwegein, The Netherlands; the Utrecht Stroke Center (L.J.K., A.A.), Utrecht, The Netherlands; the Julius Center for Health Sciences and Primary Care (A.A.), Utrecht, The Netherlands; the University of Bern (H.P.M., M.A.), Bern, Switzerland; University Hospital Basel (S.T.E., S.W.), Basel, Switzerland; Centre Hospitalier Universitaire Vaudois Lausanne (P.M.), Lausanne, Switzerland; Dresden University Stroke Center (V.P., A.K., I.D., R.v.K.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith W.","family":"Muir","sequence":"additional","affiliation":[{"name":"From St Antonius Hospital Nieuwegein (W.J.S., E.v.d.H.), Nieuwegein, The Netherlands; the Utrecht Stroke Center (L.J.K., A.A.), Utrecht, The Netherlands; the Julius Center for Health Sciences and Primary Care (A.A.), Utrecht, The Netherlands; the University of Bern (H.P.M., M.A.), Bern, Switzerland; University Hospital Basel (S.T.E., S.W.), Basel, Switzerland; Centre Hospitalier Universitaire Vaudois Lausanne (P.M.), Lausanne, Switzerland; Dresden University Stroke Center (V.P., A.K., I.D., R.v.K.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pfefferkorn","sequence":"additional","affiliation":[{"name":"From St Antonius Hospital Nieuwegein (W.J.S., E.v.d.H.), Nieuwegein, The Netherlands; the Utrecht Stroke Center (L.J.K., A.A.), Utrecht, The Netherlands; the Julius Center for Health Sciences and Primary Care (A.A.), Utrecht, The Netherlands; the University of Bern (H.P.M., M.A.), Bern, Switzerland; University Hospital Basel (S.T.E., S.W.), Basel, Switzerland; Centre Hospitalier Universitaire Vaudois Lausanne (P.M.), Lausanne, Switzerland; Dresden University Stroke Center (V.P., A.K., I.D., R.v.K.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Tanne","sequence":"additional","affiliation":[{"name":"From St Antonius Hospital Nieuwegein (W.J.S., E.v.d.H.), Nieuwegein, The Netherlands; the Utrecht Stroke Center (L.J.K., A.A.), Utrecht, The Netherlands; the Julius Center for Health Sciences and Primary Care (A.A.), Utrecht, The Netherlands; the University of Bern (H.P.M., M.A.), Bern, Switzerland; University Hospital Basel (S.T.E., S.W.), Basel, Switzerland; Centre Hospitalier Universitaire Vaudois Lausanne (P.M.), Lausanne, Switzerland; Dresden University Stroke Center (V.P., A.K., I.D., R.v.K.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Szabo","sequence":"additional","affiliation":[{"name":"From St Antonius Hospital Nieuwegein (W.J.S., E.v.d.H.), Nieuwegein, The Netherlands; the Utrecht Stroke Center (L.J.K., A.A.), Utrecht, The Netherlands; the Julius Center for Health Sciences and Primary Care (A.A.), Utrecht, The Netherlands; the University of Bern (H.P.M., M.A.), Bern, Switzerland; University Hospital Basel (S.T.E., S.W.), Basel, Switzerland; Centre Hospitalier Universitaire Vaudois Lausanne (P.M.), Lausanne, Switzerland; Dresden University Stroke Center (V.P., A.K., I.D., R.v.K.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Jaap","family":"Kappelle","sequence":"additional","affiliation":[{"name":"From St Antonius Hospital Nieuwegein (W.J.S., E.v.d.H.), Nieuwegein, The Netherlands; the Utrecht Stroke Center (L.J.K., A.A.), Utrecht, The Netherlands; the Julius Center for Health Sciences and Primary Care (A.A.), Utrecht, The Netherlands; the University of Bern (H.P.M., M.A.), Bern, Switzerland; University Hospital Basel (S.T.E., S.W.), Basel, Switzerland; Centre Hospitalier Universitaire Vaudois Lausanne (P.M.), Lausanne, Switzerland; Dresden University Stroke Center (V.P., A.K., I.D., R.v.K.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ale","family":"Algra","sequence":"additional","affiliation":[{"name":"From St Antonius Hospital Nieuwegein (W.J.S., E.v.d.H.), Nieuwegein, The Netherlands; the Utrecht Stroke Center (L.J.K., A.A.), Utrecht, The Netherlands; the Julius Center for Health Sciences and Primary Care (A.A.), Utrecht, The Netherlands; the University of Bern (H.P.M., M.A.), Bern, Switzerland; University Hospital Basel (S.T.E., S.W.), Basel, Switzerland; Centre Hospitalier Universitaire Vaudois Lausanne (P.M.), Lausanne, Switzerland; Dresden University Stroke Center (V.P., A.K., I.D., R.v.K.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruediger","family":"von Kummer","sequence":"additional","affiliation":[{"name":"From St Antonius Hospital Nieuwegein (W.J.S., E.v.d.H.), Nieuwegein, The Netherlands; the Utrecht Stroke Center (L.J.K., A.A.), Utrecht, The Netherlands; the Julius Center for Health Sciences and Primary Care (A.A.), Utrecht, The Netherlands; the University of Bern (H.P.M., M.A.), Bern, Switzerland; University Hospital Basel (S.T.E., S.W.), Basel, Switzerland; Centre Hospitalier Universitaire Vaudois Lausanne (P.M.), Lausanne, Switzerland; Dresden University Stroke Center (V.P., A.K., I.D., R.v.K.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Demchuk","sequence":"additional","affiliation":[{"name":"From St Antonius Hospital Nieuwegein (W.J.S., E.v.d.H.), Nieuwegein, The Netherlands; the Utrecht Stroke Center (L.J.K., A.A.), Utrecht, The Netherlands; the Julius Center for Health Sciences and Primary Care (A.A.), Utrecht, The Netherlands; the University of Bern (H.P.M., M.A.), Bern, Switzerland; University Hospital Basel (S.T.E., S.W.), Basel, Switzerland; Centre Hospitalier Universitaire Vaudois Lausanne (P.M.), Lausanne, Switzerland; Dresden University Stroke Center (V.P., A.K., I.D., R.v.K.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter J.","family":"Schonewille","sequence":"additional","affiliation":[{"name":"From St Antonius Hospital Nieuwegein (W.J.S., E.v.d.H.), Nieuwegein, The Netherlands; the Utrecht Stroke Center (L.J.K., A.A.), Utrecht, The Netherlands; the Julius Center for Health Sciences and Primary Care (A.A.), Utrecht, The Netherlands; the University of Bern (H.P.M., M.A.), Bern, Switzerland; University Hospital Basel (S.T.E., S.W.), Basel, Switzerland; Centre Hospitalier Universitaire Vaudois Lausanne (P.M.), Lausanne, Switzerland; Dresden University Stroke Center (V.P., A.K., I.D., R.v.K.),..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70173-5"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.049924"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000202582.29510.6b"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000181116.15426.58"},{"key":"e_1_3_4_6_2","first-page":"1612","article-title":"Using the baseline CT scan to select acute stroke patients for IV\u2013IA therapy","volume":"27","author":"Hill MD","year":"2006","unstructured":"Hill MD, Demchuk AM, Tomsick TA, Palesch YY, Broderick JP. Using the baseline CT scan to select acute stroke patients for IV\u2013IA therapy. 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