{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:16Z","timestamp":1787018116547,"version":"build-2736575974"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>\n                      <jats:italic>ANRIL<\/jats:italic>\n                      encodes a long antisense noncoding RNA in the\n                      <jats:italic>INK4<\/jats:italic>\n                      locus. Although\n                      <jats:italic>ANRIL<\/jats:italic>\n                      has been proven to be associated with coronary heart disease, its roles in stroke are inconsistent, and sparse data are available regarding hemorrhagic stroke.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>\n                      A Chinese case-control study was conducted, comprising 1657 cases (724 atherothrombosis, 466 lacunar infarction, and 462 hemorrhagic strokes) and 1664 controls. Stroke patients were prospectively followed-up for a median of 4.5 (range, 0.1\u20136.0) years. Expression of\n                      <jats:italic>ANRIL<\/jats:italic>\n                      transcripts was examined in 42 human atherosclerotic plaques.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>\n                      After adjustment for vascular risk factors and correction for multiple comparisons, subjects carrying the GG genotype of rs10757278 had 1.47-fold (95% CI, 1.11\u20131.89;\n                      <jats:italic>P<\/jats:italic>\n                      =0.05) and 1.60-fold (95% CI, 1.16\u20132.15;\n                      <jats:italic>P<\/jats:italic>\n                      =0.04) increased risk for atherothrombotic and hemorrhagic strokes, respectively. During the follow-up, 317 recurrent strokes and 301 deaths from all causes were documented. Subjects carrying rs10757278GG had higher risk for stroke recurrence (relative risk [RR],1.56; 95% CI,1.15\u20132.12;\n                      <jats:italic>P<\/jats:italic>\n                      =0.005) and cardiovascular mortality (RR, 2.0; 95% CI, 1.26\u20133.18;\n                      <jats:italic>P<\/jats:italic>\n                      =0.003), respectively. Rs10757274 was also associated with stroke risk and recurrence. Family history of stroke further increased the stroke risk by 2.37-fold (95% CI, 1.38\u20134.06;\n                      <jats:italic>P<\/jats:italic>\n                      =0.01) and recurrent stroke risk by 2.45-fold (95% CI, 1.56\u20133.86;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001) respectively, when compared with those carrying none of G-alleles and without family history. Finally, rs10757278 was associated with differential expression of the\n                      <jats:italic>ANRIL<\/jats:italic>\n                      transcripts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>\n                      Our findings indicated that the\n                      <jats:italic>ANRIL<\/jats:italic>\n                      may serve as a novel genetic marker for the risk of atherothrombotic and hemorrhagic stroke and their recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.111.625442","type":"journal-article","created":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T23:00:46Z","timestamp":1319756446000},"page":"14-21","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":71,"title":["Variants on Chromosome 9p21.3 Correlated With\n                    <i>ANRIL<\/i>\n                    Expression Contribute to Stroke Risk and Recurrence in a Large Prospective Stroke Population"],"prefix":"10.1161","volume":"43","author":[{"given":"Weili","family":"Zhang","sequence":"first","affiliation":[{"name":"From the State Key Laboratory of Cardiovascular Disease (W.Z., J.C., Y.T., R.H.), Sino-German Laboratory for Molecular Medicine and Key Laboratory for Clinical Cardiovascular Genetics (W.Z., Y.C., J.C., Y.W., J.L., R.H.), Hypertension Division (L.S., R.H.), Department of Surgery (Y.T.), FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Cardiovascular Surgery (P.L.), China-Japan Friendship Hospital, Beijing, China; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Cardiovascular Disease (W.Z., J.C., Y.T., R.H.), Sino-German Laboratory for Molecular Medicine and Key Laboratory for Clinical Cardiovascular Genetics (W.Z., Y.C., J.C., Y.W., J.L., R.H.), Hypertension Division (L.S., R.H.), Department of Surgery (Y.T.), FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Cardiovascular Surgery (P.L.), China-Japan Friendship Hospital, Beijing, China; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Cardiovascular Disease (W.Z., J.C., Y.T., R.H.), Sino-German Laboratory for Molecular Medicine and Key Laboratory for Clinical Cardiovascular Genetics (W.Z., Y.C., J.C., Y.W., J.L., R.H.), Hypertension Division (L.S., R.H.), Department of Surgery (Y.T.), FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Cardiovascular Surgery (P.L.), China-Japan Friendship Hospital, Beijing, China; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhou","family":"Chen","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Cardiovascular Disease (W.Z., J.C., Y.T., R.H.), Sino-German Laboratory for Molecular Medicine and Key Laboratory for Clinical Cardiovascular Genetics (W.Z., Y.C., J.C., Y.W., J.L., R.H.), Hypertension Division (L.S., R.H.), Department of Surgery (Y.T.), FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Cardiovascular Surgery (P.L.), China-Japan Friendship Hospital, Beijing, China; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Song","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Cardiovascular Disease (W.Z., J.C., Y.T., R.H.), Sino-German Laboratory for Molecular Medicine and Key Laboratory for Clinical Cardiovascular Genetics (W.Z., Y.C., J.C., Y.W., J.L., R.H.), Hypertension Division (L.S., R.H.), Department of Surgery (Y.T.), FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Cardiovascular Surgery (P.L.), China-Japan Friendship Hospital, Beijing, China; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Tang","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Cardiovascular Disease (W.Z., J.C., Y.T., R.H.), Sino-German Laboratory for Molecular Medicine and Key Laboratory for Clinical Cardiovascular Genetics (W.Z., Y.C., J.C., Y.W., J.L., R.H.), Hypertension Division (L.S., R.H.), Department of Surgery (Y.T.), FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Cardiovascular Surgery (P.L.), China-Japan Friendship Hospital, Beijing, China; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyao","family":"Wang","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Cardiovascular Disease (W.Z., J.C., Y.T., R.H.), Sino-German Laboratory for Molecular Medicine and Key Laboratory for Clinical Cardiovascular Genetics (W.Z., Y.C., J.C., Y.W., J.L., R.H.), Hypertension Division (L.S., R.H.), Department of Surgery (Y.T.), FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Cardiovascular Surgery (P.L.), China-Japan Friendship Hospital, Beijing, China; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jibin","family":"Liu","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Cardiovascular Disease (W.Z., J.C., Y.T., R.H.), Sino-German Laboratory for Molecular Medicine and Key Laboratory for Clinical Cardiovascular Genetics (W.Z., Y.C., J.C., Y.W., J.L., R.H.), Hypertension Division (L.S., R.H.), Department of Surgery (Y.T.), FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Cardiovascular Surgery (P.L.), China-Japan Friendship Hospital, Beijing, China; Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank B.","family":"Hu","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Cardiovascular Disease (W.Z., J.C., Y.T., R.H.), Sino-German Laboratory for Molecular Medicine and Key Laboratory for Clinical Cardiovascular Genetics (W.Z., Y.C., J.C., Y.W., J.L., R.H.), Hypertension Division (L.S., R.H.), Department of Surgery (Y.T.), FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; 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