{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:12:32Z","timestamp":1783775552843,"version":"3.55.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>The Carotid Occlusion Surgery Study (COSS) was an improvement over the Extracranial\u2013Intracranial Bypass Study, which did not utilize physiological selection. To assess possible reasons for early closure of the COSS trial, we reviewed COSS methods used to identify high-risk patients and compared results with separate quantitative data.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Increased oxygen extraction fraction (OEF) by positron emission tomography is a gold standard for ischemia, but the specific thresholds and equivalency of the semiquantitative OEF ratio utilized in COSS and quantitative OEF are at issue.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>The semiquantitative hemispheric OEF ratio used in COSS did not identify the same group of patients as did quantitative OEF using a threshold of 50%.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>The failure of COSS is likely caused by a failure of the semiquantitative, hemispheric OEF ratio method rather than by the selection for bypass based on hemodynamic compromise.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.111.627745","type":"journal-article","created":{"date-parts":[[2011,9,30]],"date-time":"2011-09-30T11:52:01Z","timestamp":1317383521000},"page":"3637-3639","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":61,"title":["Failure of Cerebral Hemodynamic Selection in General or of Specific Positron Emission Tomography Methodology?"],"prefix":"10.1161","volume":"42","author":[{"given":"Andrew P.","family":"Carlson","sequence":"first","affiliation":[{"name":"From the Department of Neurosurgery (A.P.C., H.Y., E.M.N.), University of New Mexico, Albuquerque, NM; Department of Neurosurgery (Y.-F.C.), University of Pittsburgh, Pittsburgh, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Yonas","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (A.P.C., H.Y., E.M.N.), University of New Mexico, Albuquerque, NM; Department of Neurosurgery (Y.-F.C.), University of Pittsburgh, Pittsburgh, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Fang","family":"Chang","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (A.P.C., H.Y., E.M.N.), University of New Mexico, Albuquerque, NM; Department of Neurosurgery (Y.-F.C.), University of Pittsburgh, Pittsburgh, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin M.","family":"Nemoto","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery (A.P.C., H.Y., E.M.N.), University of New Mexico, Albuquerque, NM; Department of Neurosurgery (Y.-F.C.), University of Pittsburgh, Pittsburgh, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3171\/foc.2003.14.3.10"},{"key":"e_1_3_3_3_2","volume-title":"International Stroke Conference 2011","author":"Powers WJ","unstructured":"Powers WJ, Clarke WR, Grubb RL, Videen T, Adams HP, Derdeyn CP. Results of the carotid occlusion surgery study [abstract]. International Stroke Conference 2011, Los Angeles, CA, February 9\u201311, 2011."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198511073131904"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.12.1055"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2008.02.033"},{"key":"e_1_3_3_7_2","first-page":"1992","article-title":"Significance of increased oxygen extraction fraction in five-year prognosis of major cerebral arterial occlusive diseases","volume":"40","author":"Yamauchi H","year":"1999","unstructured":"Yamauchi H, Fukuyama H, Nagahama Y, Nabatame H, Ueno M, Nishizawa S, et al.. Significance of increased oxygen extraction fraction in five-year prognosis of major cerebral arterial occlusive diseases. 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J Nucl Med. 2001;42:1195\u20131197.","journal-title":"J Nucl Med"},{"key":"e_1_3_3_12_2","first-page":"843","article-title":"Benefits of statin therapy and compliance in high risk cardiovascular patients","volume":"6","author":"Lardizabal JA","year":"2010","unstructured":"Lardizabal JA, Deedwania PC. Benefits of statin therapy and compliance in high risk cardiovascular patients. Vasc Health Risk Manag. 2010;6:843\u2013853.","journal-title":"Vasc Health Risk Manag"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.111.627745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:14:10Z","timestamp":1715609650000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.111.627745"}},"subtitle":["Carotid Occlusion Surgery Study (COSS)"],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":11,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1161\/STROKEAHA.111.627745"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.111.627745","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"2011-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-09-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}