{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:37:01Z","timestamp":1791261421032,"version":"4.1.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Cortical ischemia induces neural progenitor cell migration toward the injury site; however, whether these cells are capable of maintaining the migratory response for a longer period after injury remains uncertain.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>\n              We analyzed progenitor migration up to 1 year after induction of photothrombotic stroke to the mouse neocortex. Migrating progenitors identified as doublecortin positive cells (DCX\n              <jats:sup>+<\/jats:sup>\n              ) were assessed using the immunohistochemistry and immunofluorescence. The thymidine analogues chlorodeoxyuridine and iododeoxyuridine were used to birth-date the progenitor cells.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              In the striatum, we detected elevated numbers of DCX\n              <jats:sup>+<\/jats:sup>\n              cells up to 6 weeks postlesion. In the corpus callosum and the peri-infarct cortex (Ctx), DCX\n              <jats:sup>+<\/jats:sup>\n              cell numbers were increased up to 1 year. The orientation of the migrating progenitors was mostly aligned with the corpus callosum fiber tract at all time points; however, in the Ctx, they aligned parallel to the infarct border. The injured cortex continuously receives new progenitors up to 1 year after lesion. Cells born after lesion did not become mature neurons, although a portion of the migrating progenitors showed initial signs of differentiation into neurons.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Neural progenitors might have a role in brain plasticity after cortical stroke, especially considering the prolonged window of migratory responses of up to 1 year after stroke lesion.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.111.627802","type":"journal-article","created":{"date-parts":[[2011,10,7]],"date-time":"2011-10-07T06:24:02Z","timestamp":1317968642000},"page":"3559-3565","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":64,"title":["Long-Term Stimulation of Neural Progenitor Cell Migration After Cortical Ischemia in Mice"],"prefix":"10.1161","volume":"42","author":[{"given":"Ahmed M.","family":"Osman","sequence":"first","affiliation":[{"name":"From the Center for Brain Repair and Rehabilitation (A.M.O., M.J.P., M.N., H.G.K.), Institute for Neuroscience and Physiology, University of Gothenburg, Sweden; Faculty of Veterinary Medicine (A.M.O.), University of Khartoum, Khartoum, Sudan; Sahlgrenska University Hospital (M.N.), Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle J.","family":"Porritt","sequence":"additional","affiliation":[{"name":"From the Center for Brain Repair and Rehabilitation (A.M.O., M.J.P., M.N., H.G.K.), Institute for Neuroscience and Physiology, University of Gothenburg, Sweden; Faculty of Veterinary Medicine (A.M.O.), University of Khartoum, Khartoum, Sudan; Sahlgrenska University Hospital (M.N.), Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Nilsson","sequence":"additional","affiliation":[{"name":"From the Center for Brain Repair and Rehabilitation (A.M.O., M.J.P., M.N., H.G.K.), Institute for Neuroscience and Physiology, University of Gothenburg, Sweden; Faculty of Veterinary Medicine (A.M.O.), University of Khartoum, Khartoum, Sudan; Sahlgrenska University Hospital (M.N.), Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Georg","family":"Kuhn","sequence":"additional","affiliation":[{"name":"From the Center for Brain Repair and Rehabilitation (A.M.O., M.J.P., M.N., H.G.K.), Institute for Neuroscience and Physiology, University of Gothenburg, Sweden; Faculty of Veterinary Medicine (A.M.O.), University of Khartoum, Khartoum, Sudan; Sahlgrenska University Hospital (M.N.), Gothenburg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.05.027"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.05.035"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603512103"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181cbccec"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.08.006"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1109-04.2004"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5251.978"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm747"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20434"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-7431(03)00159-3"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0281"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.3171\/2010.2.JNS09989"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2009.12.001"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21546"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj174"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410170513"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10874"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80778-3"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth741"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901240303"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(02)00750-5"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.11.002"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3435"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.306"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4323-06.2006"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.488445"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22093"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.871"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.242435499"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.110.589010"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2473"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03813.x"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200008000-00002"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/35016083"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.106.477331"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23559"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.2174\/138920107780906531"},{"key":"e_1_3_4_39_2","first-page":"25","volume-title":"Adult Neurogenesis","author":"Kuhn HG","year":"2007","unstructured":"Kuhn HG, Peterson DA. Detection and phenotypic characterization of adult neurogenesis. In: , Gage FH, Kempermann G, Song H, eds. Adult Neurogenesis. Woodbury NY: Cold Spring Harbor Laboratory Press;2007:25\u201347."},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3883-04.2004"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2006.10.002"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200505072"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(01)00243-7"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2010.07.049"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40543"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21169"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.111.627802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:13:43Z","timestamp":1715609623000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.111.627802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1161\/STROKEAHA.111.627802"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.111.627802","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"2011-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-07-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-10-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}