{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:32:16Z","timestamp":1790764336767,"version":"4.1.0"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Superficial siderosis is a neurodegenerative disease caused by toxic accumulation of hemosiderin on the surface of the brain and spinal cord for which there is no known effective treatment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Oral deferiprone, a lipid-soluble iron chelator with ability to cross the blood\u2013brain barrier, at a dose of 30 mg\/kg per day was tested for safety in an open pilot study in 10 subjects with superficial siderosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>Over a 90-day period, deferiprone had no significant adverse effects on hematologic, liver, or neurological function. Ad hoc MRI assessments of the brain indicated a reduction in hemosiderin deposition in some subjects.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Deferiprone proved safe in this small population of superficial siderosis subjects. There was MRI evidence of reduced hemosiderin deposition with deferiprone. Prospectively designed efficacy studies are necessary to determine the clinical efficacy of deferiprone in superficial siderosis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.111.628032","type":"journal-article","created":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T03:00:46Z","timestamp":1319770846000},"page":"120-124","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":58,"title":["Pilot Safety Trial of Deferiprone in 10 Subjects With Superficial Siderosis"],"prefix":"10.1161","volume":"43","author":[{"given":"Michael","family":"Levy","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Johns Hopkins University, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Llinas","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Johns Hopkins University, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/118.4.1051"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0356"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000342457.22536.af"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198805000-00005"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459989210700111"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2331"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3280"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb10478.x"},{"key":"e_1_3_4_10_2","first-page":"489","article-title":"Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major: a retrospective analysis","volume":"88","author":"Piga A","year":"2003","unstructured":"Piga A, Gaglioti C, Fogliacco E, Tricta F . Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major: a retrospective analysis. Haematologica. 2003;88:489\u2013496.","journal-title":"Haematologica"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1628"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.111.628032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:04:43Z","timestamp":1715609083000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.111.628032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1161\/STROKEAHA.111.628032"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.111.628032","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1]]},"assertion":[{"value":"2011-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-09-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-10-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}