{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:31:29Z","timestamp":1791203489176,"version":"4.2.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Silent brain infarctions are associated with an increased risk of stroke in healthy individuals. Risk of recurrent stroke in patients with both symptomatic and silent brain infarction (SBI) has only been investigated in patients with cardioembolic stroke in the European Atrial Fibrillation Trial. We assessed whether patients with recent noncardioembolic stroke and SBI detected on MRI are at increased risk for recurrent stroke, other cardiovascular events, and mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>The prevalence of SBI detected on MRI was assessed in 1014 patients enrolled in the imaging substudy of the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial. The primary outcome was first recurrence of stroke in patients with both symptomatic stroke and SBI in comparison with age- and sex-matched patients with stroke without SBI. Secondary outcomes were a combined vascular end point, other vascular events, and mortality. The 2 groups were compared using conditional logistic regression.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Silent brain infarction was detected in 207 (20.4%) of the 1014 patients. Twenty-seven (13.0%) patients with SBI and 19 (9.2%) without SBI had a recurrent stroke (OR, 1.42; 95% CI, 0.79\u20132.56;\n              <jats:italic>P<\/jats:italic>\n              =0.24) during a mean follow-up of 2.5 years. Similarly, there was no statistically significant difference for all secondary outcome parameters between patients with SBI and matched patients without SBI.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>The presence of SBI in patients with recent mild noncardioembolic ischemic stroke could not be shown to be an independent risk factor for recurrent stroke, other vascular events, or a higher mortality rate.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\">http:\/\/clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT00153062.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.111.631739","type":"journal-article","created":{"date-parts":[[2012,1,21]],"date-time":"2012-01-21T02:19:29Z","timestamp":1327112369000},"page":"350-355","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Risk of Recurrent Stroke in Patients With Silent Brain Infarction in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) Imaging Substudy"],"prefix":"10.1161","volume":"43","author":[{"given":"Ralph","family":"Weber","sequence":"first","affiliation":[{"name":"From the Department of Neurology (R.W., C.W., H.C.D.) and Neuroradiology (I.W., C.M.-H., E.R.G., M.F., A.D.), University of Duisburg-Essen, Essen, Germany; Boehringer Ingelheim\u2013Ltd (J.B.), Bracknell, UK; Boehringer Ingelheim AB (K.H.), Stockholm, Sweden; the Departments of Clinical Neurosciences (A.M.D.), Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; the Department of Neurology (R.L.S.), Miller School of Medicine, University of Miami, Miami, FL; the Stroke Center and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Weimar","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.W., C.W., H.C.D.) and Neuroradiology (I.W., C.M.-H., E.R.G., M.F., A.D.), University of Duisburg-Essen, Essen, Germany; Boehringer Ingelheim\u2013Ltd (J.B.), Bracknell, UK; Boehringer Ingelheim AB (K.H.), Stockholm, Sweden; the Departments of Clinical Neurosciences (A.M.D.), Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; the Department of Neurology (R.L.S.), Miller School of Medicine, University of Miami, Miami, FL; the Stroke Center and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Wanke","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.W., C.W., H.C.D.) and Neuroradiology (I.W., C.M.-H., E.R.G., M.F., A.D.), University of Duisburg-Essen, Essen, Germany; Boehringer Ingelheim\u2013Ltd (J.B.), Bracknell, UK; Boehringer Ingelheim AB (K.H.), Stockholm, Sweden; the Departments of Clinical Neurosciences (A.M.D.), Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; the Department of Neurology (R.L.S.), Miller School of Medicine, University of Miami, Miami, FL; the Stroke Center and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"M\u00f6ller-Hartmann","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.W., C.W., H.C.D.) and Neuroradiology (I.W., C.M.-H., E.R.G., M.F., A.D.), University of Duisburg-Essen, Essen, Germany; Boehringer Ingelheim\u2013Ltd (J.B.), Bracknell, UK; Boehringer Ingelheim AB (K.H.), Stockholm, Sweden; the Departments of Clinical Neurosciences (A.M.D.), Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; the Department of Neurology (R.L.S.), Miller School of Medicine, University of Miami, Miami, FL; the Stroke Center and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke R.","family":"Gizewski","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.W., C.W., H.C.D.) and Neuroradiology (I.W., C.M.-H., E.R.G., M.F., A.D.), University of Duisburg-Essen, Essen, Germany; Boehringer Ingelheim\u2013Ltd (J.B.), Bracknell, UK; Boehringer Ingelheim AB (K.H.), Stockholm, Sweden; the Departments of Clinical Neurosciences (A.M.D.), Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; the Department of Neurology (R.L.S.), Miller School of Medicine, University of Miami, Miami, FL; the Stroke Center and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Blatchford","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.W., C.W., H.C.D.) and Neuroradiology (I.W., C.M.-H., E.R.G., M.F., A.D.), University of Duisburg-Essen, Essen, Germany; Boehringer Ingelheim\u2013Ltd (J.B.), Bracknell, UK; Boehringer Ingelheim AB (K.H.), Stockholm, Sweden; the Departments of Clinical Neurosciences (A.M.D.), Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; the Department of Neurology (R.L.S.), Miller School of Medicine, University of Miami, Miami, FL; the Stroke Center and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Hermansson","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.W., C.W., H.C.D.) and Neuroradiology (I.W., C.M.-H., E.R.G., M.F., A.D.), University of Duisburg-Essen, Essen, Germany; Boehringer Ingelheim\u2013Ltd (J.B.), Bracknell, UK; Boehringer Ingelheim AB (K.H.), Stockholm, Sweden; the Departments of Clinical Neurosciences (A.M.D.), Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; the Department of Neurology (R.L.S.), Miller School of Medicine, University of Miami, Miami, FL; the Stroke Center and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Demchuk","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.W., C.W., H.C.D.) and Neuroradiology (I.W., C.M.-H., E.R.G., M.F., A.D.), University of Duisburg-Essen, Essen, Germany; Boehringer Ingelheim\u2013Ltd (J.B.), Bracknell, UK; Boehringer Ingelheim AB (K.H.), Stockholm, Sweden; the Departments of Clinical Neurosciences (A.M.D.), Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; the Department of Neurology (R.L.S.), Miller School of Medicine, University of Miami, Miami, FL; the Stroke Center and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Forsting","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.W., C.W., H.C.D.) and Neuroradiology (I.W., C.M.-H., E.R.G., M.F., A.D.), University of Duisburg-Essen, Essen, Germany; Boehringer Ingelheim\u2013Ltd (J.B.), Bracknell, UK; Boehringer Ingelheim AB (K.H.), Stockholm, Sweden; the Departments of Clinical Neurosciences (A.M.D.), Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; the Department of Neurology (R.L.S.), Miller School of Medicine, University of Miami, Miami, FL; the Stroke Center and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph L.","family":"Sacco","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.W., C.W., H.C.D.) and Neuroradiology (I.W., C.M.-H., E.R.G., M.F., A.D.), University of Duisburg-Essen, Essen, Germany; Boehringer Ingelheim\u2013Ltd (J.B.), Bracknell, UK; Boehringer Ingelheim AB (K.H.), Stockholm, Sweden; the Departments of Clinical Neurosciences (A.M.D.), Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; the Department of Neurology (R.L.S.), Miller School of Medicine, University of Miami, Miami, FL; the Stroke Center and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Saver","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.W., C.W., H.C.D.) and Neuroradiology (I.W., C.M.-H., E.R.G., M.F., A.D.), University of Duisburg-Essen, Essen, Germany; Boehringer Ingelheim\u2013Ltd (J.B.), Bracknell, UK; Boehringer Ingelheim AB (K.H.), Stockholm, Sweden; the Departments of Clinical Neurosciences (A.M.D.), Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; the Department of Neurology (R.L.S.), Miller School of Medicine, University of Miami, Miami, FL; the Stroke Center and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Warach","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.W., C.W., H.C.D.) and Neuroradiology (I.W., C.M.-H., E.R.G., M.F., A.D.), University of Duisburg-Essen, Essen, Germany; Boehringer Ingelheim\u2013Ltd (J.B.), Bracknell, UK; Boehringer Ingelheim AB (K.H.), Stockholm, Sweden; the Departments of Clinical Neurosciences (A.M.D.), Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; the Department of Neurology (R.L.S.), Miller School of Medicine, University of Miami, Miami, FL; the Stroke Center and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Christoph","family":"Diener","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.W., C.W., H.C.D.) and Neuroradiology (I.W., C.M.-H., E.R.G., M.F., A.D.), University of Duisburg-Essen, Essen, Germany; Boehringer Ingelheim\u2013Ltd (J.B.), Bracknell, UK; Boehringer Ingelheim AB (K.H.), Stockholm, Sweden; the Departments of Clinical Neurosciences (A.M.D.), Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; the Department of Neurology (R.L.S.), Miller School of Medicine, University of Miami, Miami, FL; the Stroke Center and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Diehl","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.W., C.W., H.C.D.) and Neuroradiology (I.W., C.M.-H., E.R.G., M.F., A.D.), University of Duisburg-Essen, Essen, Germany; Boehringer Ingelheim\u2013Ltd (J.B.), Bracknell, UK; Boehringer Ingelheim AB (K.H.), Stockholm, Sweden; the Departments of Clinical Neurosciences (A.M.D.), Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; the Department of Neurology (R.L.S.), Miller School of Medicine, University of Miami, Miami, FL; the Stroke Center and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the PRoFESS Imaging Substudy Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70170-9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.108.516575"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000277521.66947.e5"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.7.1222"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000068408.82115.D2"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.12.2384"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.41.103"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.02.025"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181a711df"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.1.159"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805002"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804593"},{"key":"e_1_3_3_14_2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1159\/000100105","article-title":"Rationale, design and baseline data of a randomized, double-blind, controlled trial comparing two antithrombotic regimens (a fixed-dose combination of extended-release dipyridamole plus ASA with clopidogrel) and telmisartan versus placebo in patients with strokes: the Prevention Regimen for Effectively Avoiding Second Strokes Trial (PRoFESS)","volume":"23","author":"Diener HC","year":"2007","unstructured":"Diener HC, Sacco R, Yusuf S. 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Cerebrovasc Dis. 2007;23:368\u2013380.","journal-title":"Cerebrovasc Dis"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.220.1.r01jl09195"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.10.1932"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.12.1730"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000131928.47478.44"},{"key":"e_1_3_3_19_2","first-page":"221","article-title":"Silent infarction in patients with first-ever stroke","volume":"16","author":"Ong CT","year":"2007","unstructured":"Ong CT, WPC, Sung SF, Wu CS, Hsu YC. Silent infarction in patients with first-ever stroke. Acta Neurol Taiwan. 2007;16:221\u2013225.","journal-title":"Acta Neurol Taiwan"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.110.594754"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-008-0406-6"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00621-5"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.111.631739","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:29:42Z","timestamp":1715610582000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.111.631739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1161\/STROKEAHA.111.631739"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.111.631739","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2]]},"assertion":[{"value":"2011-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-10-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-01-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}