{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:22:30Z","timestamp":1785799350347,"version":"3.56.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Information on the clinical and hemodynamic profile of intravenous tissue-type plasminogen activator nonresponders, at different locations of arterial occlusion, may improve the selection of candidates for rescue reperfusion therapies. Therefore, we aim to investigate predictors of failing intravenous tissue-type plasminogen activator therapy according to occluded vessel and location of the clot.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>We prospectively evaluated consecutive patients with an acute ischemic stroke admitted within the first 6 hours of onset. Five hundred forty-eight patients with documented intracranial occlusion were included. Patients were categorized according to site of vessel occlusion into 4 distinct groups: proximal middle cerebral artery occlusion (n=251), distal middle cerebral artery occlusion (n=194), internal carotid artery bifurcation occlusion (n=61), and basilar artery occlusion (n=42). Recanalization was assessed on transcranial Doppler at 1 hour of tissue-type plasminogen activator bolus.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Among patients with proximal middle cerebral artery occlusion, the presence of severe extracranial internal carotid artery stenosis or occlusion (OR, 2.36; 95% CI, 1.15\u20134.84;\n              <jats:italic>P<\/jats:italic>\n              =0.02) and age &gt;74 years (OR, 1.84; 95% CI, 1.02\u20133.31;\n              <jats:italic>P<\/jats:italic>\n              =0.04) independently predicted no recanalization. No independent predictors of no recanalization were identified in patients with distal middle cerebral artery occlusion. In patients with internal carotid artery bifurcation occlusion, a previous diagnosis of hypertension (OR, 12.77; 95% CI, 2.12\u201376.88;\n              <jats:italic>P<\/jats:italic>\n              =0.05), and absence of atrial fibrillation (OR, 8.15; 95% CI, 1.40\u201347.44;\n              <jats:italic>P<\/jats:italic>\n              =0.02) emerged as independent predictors of no recanalization. Similarly, among patients with basilar artery occlusion, absence of atrial fibrillation was as an independent predictor of no recanalization (OR, 7.50; 95% CI, 1.40\u201340.35;\n              <jats:italic>P<\/jats:italic>\n              =0.02).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>The use of relevant predictors of no recanalization and a rapid neurovascular evaluation may improve the selection of patients for more aggressive rescue strategies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.111.632653","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T06:11:20Z","timestamp":1322892680000},"page":"417-421","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Predictors of Tissue-Type Plasminogen Activator Nonresponders According to Location of Vessel Occlusion"],"prefix":"10.1161","volume":"43","author":[{"given":"Nuno","family":"Mendon\u00e7a","sequence":"first","affiliation":[{"name":"From the Department of Neurology (N.M.), University Hospital of Coimbra, Coimbra, Portugal; the Stroke Unit (D.R.-L., M.R., M.R., J.P., S.P., P.M., J.A.-S., J.M., C.A.M.), Department of Neurosciences, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain; and the Department of Neurology (S.B.-R.), Hospital General Universitario de Elche."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rodriguez-Luna","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (N.M.), University Hospital of Coimbra, Coimbra, Portugal; the Stroke Unit (D.R.-L., M.R., M.R., J.P., S.P., P.M., J.A.-S., J.M., C.A.M.), Department of Neurosciences, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain; and the Department of Neurology (S.B.-R.), Hospital General Universitario de Elche."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Rubiera","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (N.M.), University Hospital of Coimbra, Coimbra, Portugal; the Stroke Unit (D.R.-L., M.R., M.R., J.P., S.P., P.M., J.A.-S., J.M., C.A.M.), Department of Neurosciences, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain; and the Department of Neurology (S.B.-R.), Hospital General Universitario de Elche."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Boned-Riera","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (N.M.), University Hospital of Coimbra, Coimbra, Portugal; the Stroke Unit (D.R.-L., M.R., M.R., J.P., S.P., P.M., J.A.-S., J.M., C.A.M.), Department of Neurosciences, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain; and the Department of Neurology (S.B.-R.), Hospital General Universitario de Elche."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Ribo","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (N.M.), University Hospital of Coimbra, Coimbra, Portugal; the Stroke Unit (D.R.-L., M.R., M.R., J.P., S.P., P.M., J.A.-S., J.M., C.A.M.), Department of Neurosciences, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain; and the Department of Neurology (S.B.-R.), Hospital General Universitario de Elche."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Pagola","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (N.M.), University Hospital of Coimbra, Coimbra, Portugal; the Stroke Unit (D.R.-L., M.R., M.R., J.P., S.P., P.M., J.A.-S., J.M., C.A.M.), Department of Neurosciences, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain; and the Department of Neurology (S.B.-R.), Hospital General Universitario de Elche."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Socorro","family":"Pi\u00f1eiro","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (N.M.), University Hospital of Coimbra, Coimbra, Portugal; the Stroke Unit (D.R.-L., M.R., M.R., J.P., S.P., P.M., J.A.-S., J.M., C.A.M.), Department of Neurosciences, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain; and the Department of Neurology (S.B.-R.), Hospital General Universitario de Elche."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Meler","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (N.M.), University Hospital of Coimbra, Coimbra, Portugal; the Stroke Unit (D.R.-L., M.R., M.R., J.P., S.P., P.M., J.A.-S., J.M., C.A.M.), Department of Neurosciences, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain; and the Department of Neurology (S.B.-R.), Hospital General Universitario de Elche."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Alvarez-Sabin","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (N.M.), University Hospital of Coimbra, Coimbra, Portugal; the Stroke Unit (D.R.-L., M.R., M.R., J.P., S.P., P.M., J.A.-S., J.M., C.A.M.), Department of Neurosciences, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain; and the Department of Neurology (S.B.-R.), Hospital General Universitario de Elche."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Montaner","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (N.M.), University Hospital of Coimbra, Coimbra, Portugal; the Stroke Unit (D.R.-L., M.R., M.R., J.P., S.P., P.M., J.A.-S., J.M., C.A.M.), Department of Neurosciences, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain; and the Department of Neurology (S.B.-R.), Hospital General Universitario de Elche."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Molina","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (N.M.), University Hospital of Coimbra, Coimbra, Portugal; the Stroke Unit (D.R.-L., M.R., M.R., J.P., S.P., P.M., J.A.-S., J.M., C.A.M.), Department of Neurosciences, Hospital Universitari Vall d'Hebron, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain; and the Department of Neurology (S.B.-R.), Hospital General Universitario de Elche."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910143411618"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804656"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000160007.57787.4c"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000106485.04500.4a"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000143321.37482.b3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000110219.67054.bf"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000237070.80133.1d"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2006.08.002"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000250341.38014.d2"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.12.2598"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000121641.77121.98"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.110.597104"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000171066.25248.1d"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.497115"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.11.2220"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.1.89"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2292030516"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/hs0102.101892"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.5.1128"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.609693"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000086465.41263.06"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.111.632653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:29:44Z","timestamp":1715610584000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.111.632653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1161\/STROKEAHA.111.632653"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.111.632653","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2]]},"assertion":[{"value":"2011-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-10-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}