{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:05:59Z","timestamp":1779894359947,"version":"3.53.1"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Cerebral vascular reactivity assessment is typically performed with 2 perfusion measurements before and after a vasodilatory challenge. The aim of this study was to assess the time course of the vasodilatory effect in the brain-feeding arteries after a challenge with acetazolamide in patients with a stenosis of the internal carotid artery (ICA).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Twenty-one patients with a symptomatic ICA stenosis and 18 healthy control subjects underwent 2-dimensional phase-contrast MR angiography to repeatedly measure the blood flow (mL\/min) in both ICAs at baseline and in 5-minute intervals for 30 minutes after intravenous administration of acetazolamide.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              At baseline, the blood flow was significantly lower in the stenosed ICAs of patients (155\u00b117 mL\/min) than in the contralateral ICAs (237\u00b121 mL\/min,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) and the ICAs of healthy control subjects (249\u00b115 mL\/min,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) and remained lower throughout the time course. The maximum vasodilatory effect in the stenosed ICAs was observed after 15.3\u00b10.9 minutes, which was significantly later than in the contralateral ICAs (within 12.9\u00b10.7 minutes,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) and healthy ICAs (within 12.8\u00b10.8 minutes,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>The onset of the maximum vasodilatory effect after administration of acetazolamide is delayed in patients with a symptomatic ICA stenosis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.111.637314","type":"journal-article","created":{"date-parts":[[2011,11,4]],"date-time":"2011-11-04T05:03:03Z","timestamp":1320382983000},"page":"553-556","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Time Course of Vascular Reactivity Using Repeated Phase-Contrast MR Angiography in Patients With Carotid Artery Stenosis"],"prefix":"10.1161","volume":"43","author":[{"given":"Nolan S.","family":"Hartkamp","sequence":"first","affiliation":[{"name":"From the Departments of Radiology (N.S.H., J.H., R.P.H.B.) and Vascular Surgery (G.J.d.B.), University Medical Center Utrecht, Utrecht, the Netherlands; and the Department of Neurology (H.B.v.d.W.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Hendrikse","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (N.S.H., J.H., R.P.H.B.) and Vascular Surgery (G.J.d.B.), University Medical Center Utrecht, Utrecht, the Netherlands; and the Department of Neurology (H.B.v.d.W.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Bart","family":"van der Worp","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (N.S.H., J.H., R.P.H.B.) and Vascular Surgery (G.J.d.B.), University Medical Center Utrecht, Utrecht, the Netherlands; and the Department of Neurology (H.B.v.d.W.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert J.","family":"de Borst","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (N.S.H., J.H., R.P.H.B.) and Vascular Surgery (G.J.d.B.), University Medical Center Utrecht, Utrecht, the Netherlands; and the Department of Neurology (H.B.v.d.W.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinoud P.H.","family":"Bokkers","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (N.S.H., J.H., R.P.H.B.) and Vascular Surgery (G.J.d.B.), University Medical Center Utrecht, Utrecht, the Netherlands; and the Department of Neurology (H.B.v.d.W.), Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1993.79.4.0483"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.3.457"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2006.00080.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2007.10.030"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0b013e318188887d"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10091262"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.12.2302"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10133"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10188"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000021900.58396.44"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.5.604"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(95)02005-E"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.8.1913"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2438"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.111.637314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:30:35Z","timestamp":1715610635000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.111.637314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1161\/STROKEAHA.111.637314"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.111.637314","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2]]},"assertion":[{"value":"2011-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-09-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-11-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}