{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:29:26Z","timestamp":1791307766966,"version":"4.3.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>Endovascular therapy of acute ischemic stroke has been shown to be beneficial for selected patients. The purpose of this study is to determine predictors of outcome in a large cohort of patients treated with intra-arterial thrombolysis, mechanical revascularization techniques, or both.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>We prospectively acquired data for 623 patients with acute cerebral infarcts in the carotid artery territory who received endovascular treatment at a single center. Logistic regression analysis was performed to determine predictors of outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>\n                      Median National Institutes of Health Stroke Scale (NIHSS) at admission was 15. Partial or complete recanalization was achieved in 70.3% of patients; it was independently associated with hypercholesterolemia (\n                      <jats:italic>P<\/jats:italic>\n                      =0.02), absence of coronary artery disease (\n                      <jats:italic>P<\/jats:italic>\n                      =0.023), and more proximal occlusion site (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001). After 3 months, 80.5% of patients had survived, and 48.9% of patients reached favorable outcome (modified Rankin scale score 0\u20132). Good collaterals (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001), recanalization (\n                      <jats:italic>P<\/jats:italic>\n                      =0.023), hypercholesterolemia (\n                      <jats:italic>P<\/jats:italic>\n                      =0.03), lower NIHSS at admission (\n                      <jats:italic>P<\/jats:italic>\n                      =0.001), and younger age (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001) were independent predictors for survival. More peripheral occlusion site (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001), recanalization (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001), hypercholesterolemia (\n                      <jats:italic>P<\/jats:italic>\n                      =0.002), good collaterals (\n                      <jats:italic>P<\/jats:italic>\n                      =0.002), lower NIHSS (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001), younger age (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.0001), absence of diabetes (\n                      <jats:italic>P<\/jats:italic>\n                      =0.002), and no previous antithrombotic therapy (\n                      <jats:italic>P<\/jats:italic>\n                      =0.036) predicted favorable outcome. Time to treatment was only a predictor of outcome, when collaterals were excluded from the model. Symptomatic intracerebral hemorrhage occurred in 5.5% and was independently predicted by poor collaterals (\n                      <jats:italic>P<\/jats:italic>\n                      =0.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Several independent predictors for outcome and complications were identified. Unlike in intravenous thrombolysis trials, time to treatment was a predictor of outcome only when collaterals were excluded from the model, indicating the important role of collaterals for the time window.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.111.639112","type":"journal-article","created":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T01:41:15Z","timestamp":1330047675000},"page":"1052-1057","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":111,"title":["Endovascular Therapy of 623 Patients With Anterior Circulation Stroke"],"prefix":"10.1161","volume":"43","author":[{"given":"Aekaterini","family":"Galimanis","sequence":"first","affiliation":[{"name":"From the Department of Neurology (A.G., S.J., M-L.M., U.F., O.F., A.W., N.M., G.M.D.M., H.P.M., M.A.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Diagnostic and Interventional Neuroradiology (C.B., M.E-K., G.S., J.G.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Jung","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (A.G., S.J., M-L.M., U.F., O.F., A.W., N.M., G.M.D.M., H.P.M., M.A.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Diagnostic and Interventional Neuroradiology (C.B., M.E-K., G.S., J.G.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Luise","family":"Mono","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (A.G., S.J., M-L.M., U.F., O.F., A.W., N.M., G.M.D.M., H.P.M., M.A.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Diagnostic and Interventional Neuroradiology (C.B., M.E-K., G.S., J.G.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Fischer","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (A.G., S.J., M-L.M., U.F., O.F., A.W., N.M., G.M.D.M., H.P.M., M.A.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Diagnostic and Interventional Neuroradiology (C.B., M.E-K., G.S., J.G.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Findling","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (A.G., S.J., M-L.M., U.F., O.F., A.W., N.M., G.M.D.M., H.P.M., M.A.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Diagnostic and Interventional Neuroradiology (C.B., M.E-K., G.S., J.G.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Weck","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (A.G., S.J., M-L.M., U.F., O.F., A.W., N.M., G.M.D.M., H.P.M., M.A.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Diagnostic and Interventional Neuroradiology (C.B., M.E-K., G.S., J.G.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklaus","family":"Meier","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (A.G., S.J., M-L.M., U.F., O.F., A.W., N.M., G.M.D.M., H.P.M., M.A.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Diagnostic and Interventional Neuroradiology (C.B., M.E-K., G.S., J.G.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian","family":"Marco De Marchis","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (A.G., S.J., M-L.M., U.F., O.F., A.W., N.M., G.M.D.M., H.P.M., M.A.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Diagnostic and Interventional Neuroradiology (C.B., M.E-K., G.S., J.G.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caspar","family":"Brekenfeld","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (A.G., S.J., M-L.M., U.F., O.F., A.W., N.M., G.M.D.M., H.P.M., M.A.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Diagnostic and Interventional Neuroradiology (C.B., M.E-K., G.S., J.G.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan","family":"El-Koussy","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (A.G., S.J., M-L.M., U.F., O.F., A.W., N.M., G.M.D.M., H.P.M., M.A.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Diagnostic and Interventional Neuroradiology (C.B., M.E-K., G.S., J.G.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich P.","family":"Mattle","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (A.G., S.J., M-L.M., U.F., O.F., A.W., N.M., G.M.D.M., H.P.M., M.A.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Diagnostic and Interventional Neuroradiology (C.B., M.E-K., G.S., J.G.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Arnold","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (A.G., S.J., M-L.M., U.F., O.F., A.W., N.M., G.M.D.M., H.P.M., M.A.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Diagnostic and Interventional Neuroradiology (C.B., M.E-K., G.S., J.G.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Schroth","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (A.G., S.J., M-L.M., U.F., O.F., A.W., N.M., G.M.D.M., H.P.M., M.A.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland; and Department of Diagnostic and Interventional Neuroradiology (C.B., M.E-K., G.S., J.G.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Gralla","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (A.G., S.J., M-L.M., U.F., O.F., A.W., N.M., G.M.D.M., H.P.M., M.A.), Inselspital, University Hospital Bern and University of Bern, Bern, Switzerland; 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