{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T01:25:07Z","timestamp":1793669107626,"version":"4.5.1"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Pretreatment infarct volume appears to predict clinical outcome after intra-arterial therapy. To confirm the importance of infarct size in patients undergoing intra-arterial therapy, we sought to characterize the relationship between final infarct volume (FIV) and long-term functional outcome in a prospective cohort of endovascularly treated patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>From our prospective intra-arterial therapy database, we identified 107 patients with acute ischemic stroke with anterior circulation proximal artery occlusions who underwent final infarct imaging and had 3-month modified Rankin Scale scores. Clinical, imaging, treatment, and outcome data were analyzed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Mean age was 66.6 years. Median admission National Institutes of Health Stroke Scale score was 17. Reperfusion (Thrombolysis In Cerebral Infarction 2A\u20133) was achieved in 78 (72.9%) patients. Twenty-seven (25.2%) patients achieved a 3-month good outcome (modified Rankin Scale 0\u20132), and 30 (28.0%) died. Median FIV was 71.4 cm\n              <jats:sup>3<\/jats:sup>\n              . FIV independently correlated with functional outcome across the entire modified Rankin Scale. In receiver operating characteristic analysis, it was the best discriminator of both good outcome (area under the curve=0.857) and mortality (area under the curve=0.772). A FIV of approximately 50 cm\n              <jats:sup>3<\/jats:sup>\n              demonstrated the greatest accuracy for distinguishing good versus poor outcome, and a FIV of approximately 90 cm\n              <jats:sup>3<\/jats:sup>\n              was highly specific for a poor outcome. The interaction term between FIV and age was the only independent predictor of good outcome (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001). The impact of FIV was accentuated in patients &lt;80 years.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Among patients with anterior circulation acute ischemic stroke who undergo intra-arterial therapy, final infarct volume is a critical determinant of 3-month functional outcome and appears suitable as a surrogate biomarker in proof-of-concept intra-arterial therapy trials.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.111.639401","type":"journal-article","created":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T05:52:14Z","timestamp":1331877134000},"page":"1323-1330","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":206,"title":["Infarct Volume Is a Pivotal Biomarker After Intra-Arterial Stroke Therapy"],"prefix":"10.1161","volume":"43","author":[{"given":"Albert J.","family":"Yoo","sequence":"first","affiliation":[{"name":"From the Departments of Radiology (Diagnostic [A.J.Y., Z.A.C., M.H.L., P.W.S., R.G.G.] and Interventional Neuroradiology [A.J.Y., Z.A.C., R.G.N., J.A.H.]) and Neurology (R.G.N., L.H.S.), Massachusetts General Hospital, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeshan A.","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (Diagnostic [A.J.Y., Z.A.C., M.H.L., P.W.S., R.G.G.] and Interventional Neuroradiology [A.J.Y., Z.A.C., R.G.N., J.A.H.]) and Neurology (R.G.N., L.H.S.), Massachusetts General Hospital, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul G.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (Diagnostic [A.J.Y., Z.A.C., M.H.L., P.W.S., R.G.G.] and Interventional Neuroradiology [A.J.Y., Z.A.C., R.G.N., J.A.H.]) and Neurology (R.G.N., L.H.S.), Massachusetts General Hospital, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Lev","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (Diagnostic [A.J.Y., Z.A.C., M.H.L., P.W.S., R.G.G.] and Interventional Neuroradiology [A.J.Y., Z.A.C., R.G.N., J.A.H.]) and Neurology (R.G.N., L.H.S.), Massachusetts General Hospital, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela W.","family":"Schaefer","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (Diagnostic [A.J.Y., Z.A.C., M.H.L., P.W.S., R.G.G.] and Interventional Neuroradiology [A.J.Y., Z.A.C., R.G.N., J.A.H.]) and Neurology (R.G.N., L.H.S.), Massachusetts General Hospital, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee H.","family":"Schwamm","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (Diagnostic [A.J.Y., Z.A.C., M.H.L., P.W.S., R.G.G.] and Interventional Neuroradiology [A.J.Y., Z.A.C., R.G.N., J.A.H.]) and Neurology (R.G.N., L.H.S.), Massachusetts General Hospital, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua A.","family":"Hirsch","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (Diagnostic [A.J.Y., Z.A.C., M.H.L., P.W.S., R.G.G.] and Interventional Neuroradiology [A.J.Y., Z.A.C., R.G.N., J.A.H.]) and Neurology (R.G.N., L.H.S.), Massachusetts General Hospital, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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