{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:14:16Z","timestamp":1790421256924,"version":"4.1.0"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Transverse sinus thrombosis can have nonspecific clinical and radiographic signs. We hypothesized that the novel \u201csigmoid notch sign\u201d (on head CT) can help differentiate transverse sinus thrombosis from a congenitally atretic sinus among individuals with absent signal in 1 transverse sinus by MR venography.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>We retrospectively evaluated 53 subjects with a unilaterally absent transverse sinus signal on MR venography. Eleven had true transverse sinus thrombosis and 42 had an atretic transverse sinus. Reviewers were trained in the sigmoid notch sign: \u201cpositive\u201d if 1 of the sigmoid notches was asymmetrically smaller than the other, consistent with a congenitally absent transverse sinus on that side. This sign was scored on CT scans by 2 blinded reviewers to determine if signal dropout was clot or atretic sinus. A consensus rating was reached when the reviewers disagreed. Characteristics of the sigmoid notch sign as a diagnostic test were compared with a gold standard of full chart review by an independent reviewer.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>Each reviewer had a sensitivity of 91% (detecting 10 of 11 clots based on a negative sigmoid notch sign) and specificity of 71% to 81%; consensus specificity increased to 86% (36 of 42 individuals with an atretic sinus had a positive notch sign, detecting atretic sinuses based on presence of the sign).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>Asymmetries of the sigmoid notches on noncontrast brain CT is a very sensitive and specific measure of differentiating transverse sinus thrombosis from an atretic transverse sinus when absence of transverse sinus flow is visualized on MR venography.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.112.656124","type":"journal-article","created":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T06:17:03Z","timestamp":1337149023000},"page":"1968-1970","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Differentiation of Transverse Sinus Thrombosis From Congenitally Atretic Cerebral Transverse Sinus With CT"],"prefix":"10.1161","volume":"43","author":[{"given":"Yolanda","family":"Chik","sequence":"first","affiliation":[{"name":"From the Divison of Neurology (Y.C.), Sinai Hospital, Baltimore, MD; and the Department of Neurology (R.F.G., S.Z., J.R., R.H.L.), Johns Hopkins University School of Medicine, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca F.","family":"Gottesman","sequence":"additional","affiliation":[{"name":"From the Divison of Neurology (Y.C.), Sinai Hospital, Baltimore, MD; and the Department of Neurology (R.F.G., S.Z., J.R., R.H.L.), Johns Hopkins University School of Medicine, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Zeiler","sequence":"additional","affiliation":[{"name":"From the Divison of Neurology (Y.C.), Sinai Hospital, Baltimore, MD; and the Department of Neurology (R.F.G., S.Z., J.R., R.H.L.), Johns Hopkins University School of Medicine, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"From the Divison of Neurology (Y.C.), Sinai Hospital, Baltimore, MD; and the Department of Neurology (R.F.G., S.Z., J.R., R.H.L.), Johns Hopkins University School of Medicine, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael H.","family":"Llinas","sequence":"additional","affiliation":[{"name":"From the Divison of Neurology (Y.C.), Sinai Hospital, Baltimore, MD; and the Department of Neurology (R.F.G., S.Z., J.R., R.H.L.), Johns Hopkins University School of Medicine, Baltimore, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra042354"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.26si055174"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-33-394-606"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198511000-00003"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-008-0431-5"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.112.656124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:32:40Z","timestamp":1715610760000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.112.656124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1161\/STROKEAHA.112.656124"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.112.656124","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7]]},"assertion":[{"value":"2012-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}