{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:25:08Z","timestamp":1783081508736,"version":"3.54.6"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>In a pilot study we evaluated near-infrared spectroscopy as to its potential benefit in monitoring patients with steno-occlusive disease of a major cerebral artery for alterations in cortical hemodynamics.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Cortical maps of time-to-peak (TTP) in 10 patients unilaterally affected by severe stenosis or occlusion of the middle cerebral artery were acquired by multichannel near-infrared spectroscopy after bolus application of indocyanine green. Hemodynamic manifestations were assessed by comparison between affected and unaffected hemisphere and evaluated for common constituents by principal component analysis. In one patient, TTP values were compared with those obtained by dynamic susceptibility contrast imaging.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              TTP was increased on the affected hemisphere in 9 patients. Mean difference in TTP between hemispheres was 0.44 second (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) as compared with a mean lateral difference of 0.12 second found in a control group of 10 individuals. In group analysis a significant rise in TTP was found in the distribution of the affected middle cerebral artery, whereas principal component analysis suggests augmentation of hemodynamic effects toward the border zones as a dominant pattern. A linear correlation of 0.61 between TTP values determined by dynamic susceptibility contrast MRI and near-infrared spectroscopy was found to be statistically significant (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>Multichannel near-infrared spectroscopy might facilitate detection of disease-related hemodynamic changes as yet only accessible by tomographic imaging modalities. Being indicative for hypoperfusion and collateral flow increased values of TTP, as found to a varying extent in the present patient group, might be of clinical relevance.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.112.656710","type":"journal-article","created":{"date-parts":[[2012,10,22]],"date-time":"2012-10-22T20:59:33Z","timestamp":1350939573000},"page":"2980-2985","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Assessment of Cortical Hemodynamics by Multichannel Near-Infrared Spectroscopy in Steno-Occlusive Disease of the Middle Cerebral Artery"],"prefix":"10.1161","volume":"43","author":[{"given":"Andreas","family":"Oldag","sequence":"first","affiliation":[{"name":"From the Departments of Neurology (A.O., M.G., A.-K.B., S.S., C.S., H.-J.H., K.K.) and Stereotactic Neurosurgery (K.K.), Otto-von-Guericke University, Magdeburg, Germany; the Leibniz Institute for Neurobiology, Magdeburg, Germany (M.G., H.-J.H., K.K.); and the German Center for Neurodegenerative Disorders (DZNE), Magdeburg, Germany (H.-J.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Goertler","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (A.O., M.G., A.-K.B., S.S., C.S., H.-J.H., K.K.) and Stereotactic Neurosurgery (K.K.), Otto-von-Guericke University, Magdeburg, Germany; the Leibniz Institute for Neurobiology, Magdeburg, Germany (M.G., H.-J.H., K.K.); and the German Center for Neurodegenerative Disorders (DZNE), Magdeburg, Germany (H.-J.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Katrin","family":"Bertz","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (A.O., M.G., A.-K.B., S.S., C.S., H.-J.H., K.K.) and Stereotactic Neurosurgery (K.K.), Otto-von-Guericke University, Magdeburg, Germany; the Leibniz Institute for Neurobiology, Magdeburg, Germany (M.G., H.-J.H., K.K.); and the German Center for Neurodegenerative Disorders (DZNE), Magdeburg, Germany (H.-J.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Schreiber","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (A.O., M.G., A.-K.B., S.S., C.S., H.-J.H., K.K.) and Stereotactic Neurosurgery (K.K.), Otto-von-Guericke University, Magdeburg, Germany; the Leibniz Institute for Neurobiology, Magdeburg, Germany (M.G., H.-J.H., K.K.); and the German Center for Neurodegenerative Disorders (DZNE), Magdeburg, Germany (H.-J.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Stoppel","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (A.O., M.G., A.-K.B., S.S., C.S., H.-J.H., K.K.) and Stereotactic Neurosurgery (K.K.), Otto-von-Guericke University, Magdeburg, Germany; the Leibniz Institute for Neurobiology, Magdeburg, Germany (M.G., H.-J.H., K.K.); and the German Center for Neurodegenerative Disorders (DZNE), Magdeburg, Germany (H.-J.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Jochen","family":"Heinze","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (A.O., M.G., A.-K.B., S.S., C.S., H.-J.H., K.K.) and Stereotactic Neurosurgery (K.K.), Otto-von-Guericke University, Magdeburg, Germany; the Leibniz Institute for Neurobiology, Magdeburg, Germany (M.G., H.-J.H., K.K.); 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