{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:09:12Z","timestamp":1790467752794,"version":"4.1.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Transient focal neurological episodes (TFNE) are recognized in cerebral amyloid angiopathy (CAA) and may herald a high risk of intracerebral hemorrhage (ICH). We aimed to determine their prevalence, clinical neuroimaging spectrum, and future ICH risk.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>This was a multicenter retrospective cohort study of 172 CAA patients. Clinical, imaging, and follow-up data were collected. We classified TFNE into: predominantly positive symptoms (\u201caura-like\u201d spreading paraesthesias\/positive visual phenomena or limb jerking) and predominantly negative symptoms (\u201ctransient ischemic attack\u2013like\u201d sudden-onset limb weakness, dysphasia, or visual loss). We pooled our results with all published cases identified in a systematic review.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              In our multicenter cohort, 25 patients (14.5%; 95% confidence interval, 9.6%\u201320.7%) had TFNE. Positive and negative symptoms were equally common (52% vs 48%, respectively). The commonest neuroimaging features were leukoaraiosis (84%), lobar ICH (76%), multiple lobar cerebral microbleeds (58%), and superficial cortical siderosis\/convexity subarachnoid hemorrhage (54%). The CAA patients with TFNE more often had superficial cortical siderosis\/convexity subarachnoid hemorrhage (but not other magnetic resonance imaging features) compared with those without TFNE (50% vs 19%;\n              <jats:italic>P<\/jats:italic>\n              =0.001). Over a median period of 14 months, 50% of TFNE patients had symptomatic lobar ICH. The meta-analysis showed a risk of symptomatic ICH after TFNE of 24.5% (95% confidence interval, 15.8%\u201336.9%) at 8 weeks, related neither to clinical features nor to previous symptomatic ICH.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>TFNE are common in CAA, include both positive and negative neurological symptoms, and may be caused by superficial cortical siderosis\/convexity subarachnoid hemorrhage. TFNE predict a high early risk of symptomatic ICH (which may be amenable to prevention). Blood-sensitive magnetic resonance imaging sequences are important in the investigation of such episodes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.112.657759","type":"journal-article","created":{"date-parts":[[2012,7,14]],"date-time":"2012-07-14T09:32:30Z","timestamp":1342258350000},"page":"2324-2330","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":213,"title":["Spectrum of Transient Focal Neurological Episodes in Cerebral Amyloid Angiopathy"],"prefix":"10.1161","volume":"43","author":[{"given":"Andreas","family":"Charidimou","sequence":"first","affiliation":[{"name":"From the Stroke Research Group (A.C., S.M.G., D.J.W.), UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK; Department of Neurology (A.P.), Cliniques Universitaires UCL Saint Luc, Brussels, Belgium; Biomedical Research Centre (Z.F.), UCL, UK; CHU UCL Mont-Godinne (Y.V., P.L.), Universit\u00e9 Catholique de Louvain, Louvain-la-Neuve, Belgium; Lysholm Department of Neuroradiology (H.R.J.), National Hospital for Neurology and Neurosurgery, London, UK; Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Peeters","sequence":"additional","affiliation":[{"name":"From the Stroke Research Group (A.C., S.M.G., D.J.W.), UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK; Department of Neurology (A.P.), Cliniques Universitaires UCL Saint Luc, Brussels, Belgium; Biomedical Research Centre (Z.F.), UCL, UK; CHU UCL Mont-Godinne (Y.V., P.L.), Universit\u00e9 Catholique de Louvain, Louvain-la-Neuve, Belgium; Lysholm Department of Neuroradiology (H.R.J.), National Hospital for Neurology and Neurosurgery, London, UK; Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Fox","sequence":"additional","affiliation":[{"name":"From the Stroke Research Group (A.C., S.M.G., D.J.W.), UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK; Department of Neurology (A.P.), Cliniques Universitaires UCL Saint Luc, Brussels, Belgium; Biomedical Research Centre (Z.F.), UCL, UK; CHU UCL Mont-Godinne (Y.V., P.L.), Universit\u00e9 Catholique de Louvain, Louvain-la-Neuve, Belgium; Lysholm Department of Neuroradiology (H.R.J.), National Hospital for Neurology and Neurosurgery, London, UK; Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone M.","family":"Gregoire","sequence":"additional","affiliation":[{"name":"From the Stroke Research Group (A.C., S.M.G., D.J.W.), UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK; Department of Neurology (A.P.), Cliniques Universitaires UCL Saint Luc, Brussels, Belgium; Biomedical Research Centre (Z.F.), UCL, UK; CHU UCL Mont-Godinne (Y.V., P.L.), Universit\u00e9 Catholique de Louvain, Louvain-la-Neuve, Belgium; Lysholm Department of Neuroradiology (H.R.J.), National Hospital for Neurology and Neurosurgery, London, UK; Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Vandermeeren","sequence":"additional","affiliation":[{"name":"From the Stroke Research Group (A.C., S.M.G., D.J.W.), UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK; Department of Neurology (A.P.), Cliniques Universitaires UCL Saint Luc, Brussels, Belgium; Biomedical Research Centre (Z.F.), UCL, UK; CHU UCL Mont-Godinne (Y.V., P.L.), Universit\u00e9 Catholique de Louvain, Louvain-la-Neuve, Belgium; Lysholm Department of Neuroradiology (H.R.J.), National Hospital for Neurology and Neurosurgery, London, UK; Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Laloux","sequence":"additional","affiliation":[{"name":"From the Stroke Research Group (A.C., S.M.G., D.J.W.), UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK; Department of Neurology (A.P.), Cliniques Universitaires UCL Saint Luc, Brussels, Belgium; Biomedical Research Centre (Z.F.), UCL, UK; CHU UCL Mont-Godinne (Y.V., P.L.), Universit\u00e9 Catholique de Louvain, Louvain-la-Neuve, Belgium; Lysholm Department of Neuroradiology (H.R.J.), National Hospital for Neurology and Neurosurgery, London, UK; Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans R.","family":"J\u00e4ger","sequence":"additional","affiliation":[{"name":"From the Stroke Research Group (A.C., S.M.G., D.J.W.), UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK; Department of Neurology (A.P.), Cliniques Universitaires UCL Saint Luc, Brussels, Belgium; Biomedical Research Centre (Z.F.), UCL, UK; CHU UCL Mont-Godinne (Y.V., P.L.), Universit\u00e9 Catholique de Louvain, Louvain-la-Neuve, Belgium; Lysholm Department of Neuroradiology (H.R.J.), National Hospital for Neurology and Neurosurgery, London, UK; Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Baron","sequence":"additional","affiliation":[{"name":"From the Stroke Research Group (A.C., S.M.G., D.J.W.), UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK; Department of Neurology (A.P.), Cliniques Universitaires UCL Saint Luc, Brussels, Belgium; Biomedical Research Centre (Z.F.), UCL, UK; CHU UCL Mont-Godinne (Y.V., P.L.), Universit\u00e9 Catholique de Louvain, Louvain-la-Neuve, Belgium; Lysholm Department of Neuroradiology (H.R.J.), National Hospital for Neurology and Neurosurgery, London, UK; Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Werring","sequence":"additional","affiliation":[{"name":"From the Stroke Research Group (A.C., S.M.G., D.J.W.), UCL Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK; Department of Neurology (A.P.), Cliniques Universitaires UCL Saint Luc, Brussels, Belgium; Biomedical Research Centre (Z.F.), UCL, UK; CHU UCL Mont-Godinne (Y.V., P.L.), Universit\u00e9 Catholique de Louvain, Louvain-la-Neuve, Belgium; Lysholm Department of Neuroradiology (H.R.J.), National Hospital for Neurology and Neurosurgery, London, UK; Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-301308"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.10.2073"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000088665"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1985.63.6.0963"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2006.11.028"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.111.621847"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/NRL.0b013e3181963f0c"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03214.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.4.537"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c34a7d"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c17fa1"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dad605"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.1.81"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.541782.AD"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000098060"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d55efa"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr172"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.112.657759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:35:50Z","timestamp":1715610950000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.112.657759"}},"subtitle":["Multicentre Magnetic Resonance Imaging Cohort Study and Meta-Analysis"],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1161\/STROKEAHA.112.657759"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.112.657759","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9]]},"assertion":[{"value":"2012-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-06-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-07-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}