{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:02:59Z","timestamp":1791291779763,"version":"4.1.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Intracranial atherosclerotic disease (ICAD) remains a challenge for stroke primary and secondary prevention. Molecular pathways involved in the development of ICAD from its asymptomatic stages are largely unknown. In our population-based study, we aimed to compare the risk factor and biomarker profiles associated with intracranial and extracranial asymptomatic cerebral atherosclerosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>The Asymptomatic Intracranial Atherosclerosis (AsIA) study cohort includes a random sample population of 933 white subjects &gt;50 years with a moderate to high vascular risk (based on REGICOR score) and without a history of stroke (64% males; mean age, 66 years). Carotid and intracranial atherosclerosis were screened by cervical and transcranial color-coded Duplex ultrasound, being moderate to severe stenoses confirmed by MR angiography. We registered clinical and anthropometric data and created a biobank with blood samples at baseline. A panel of biomarkers involved in atherothrombogenesis was determined: C-reactive protein, asymmetric-dimethylarginine, resistin, and plasminogen activator inhibitor-1. Insulin resistance was quantified by Homeostasis Model Assessment index.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>After multinomial regression analyses, male sex, hypertension, smoking, and alcoholic habits were independent risk factors of isolated extracranial atherosclerotic disease. Diabetes and metabolic syndrome conferred a higher risk for ICAD than for extracranial atherosclerotic disease. Moreover, metabolic syndrome and insulin resistance were independent risk factors of moderate to severe ICAD but were not risk factors of moderate to severe extracranial atherosclerotic disease. Regarding biomarkers, asymmetric-dimethylarginine was independently associated with isolated ICAD and resistin with combined ICAD\u2013extracranial atherosclerotic disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Our findings show distinct clinical and biological profiles in subclinical ICAD and extracranial atherosclerotic disease. Insulin resistance emerged as an important molecular pathway involved in the development of ICAD from its asymptomatic stage.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.112.661702","type":"journal-article","created":{"date-parts":[[2012,7,14]],"date-time":"2012-07-14T09:32:30Z","timestamp":1342258350000},"page":"2712-2719","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":84,"title":["Biological Signatures of Asymptomatic Extra- and Intracranial Atherosclerosis"],"prefix":"10.1161","volume":"43","author":[{"given":"Elena","family":"L\u00f3pez-Cancio","sequence":"first","affiliation":[{"name":"From the Departments of Neurosciences (E.L.-C., L.D., M.J., M.H., M.M., S.R., A.S., A.D.) and Biochemistry (A.G., J.B.) and the Magnetic Resonance Unit (A.M.), Hospital Universitari Germans Trias I Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Barcelona, Spain; the Primary Healthcare Research Support Unit Metropolitana Nord, ICS-IDIAP Jordi Gol, Matar\u00f3, Barcelona, Spain (M.T.A.); and the Stroke Unit, Department of Neurology, Hospital Cl\u00ednico Universitario, Valladolid, Spain (J.F.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amparo","family":"Gal\u00e1n","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosciences (E.L.-C., L.D., M.J., M.H., M.M., S.R., A.S., A.D.) and Biochemistry (A.G., J.B.) and the Magnetic Resonance Unit (A.M.), Hospital Universitari Germans Trias I Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Barcelona, Spain; the Primary Healthcare Research Support Unit Metropolitana Nord, ICS-IDIAP Jordi Gol, Matar\u00f3, Barcelona, Spain (M.T.A.); and the Stroke Unit, Department of Neurology, Hospital Cl\u00ednico Universitario, Valladolid, Spain (J.F.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Dorado","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosciences (E.L.-C., L.D., M.J., M.H., M.M., S.R., A.S., A.D.) and Biochemistry (A.G., J.B.) and the Magnetic Resonance Unit (A.M.), Hospital Universitari Germans Trias I Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Barcelona, Spain; the Primary Healthcare Research Support Unit Metropolitana Nord, ICS-IDIAP Jordi Gol, Matar\u00f3, Barcelona, Spain (M.T.A.); and the Stroke Unit, Department of Neurology, Hospital Cl\u00ednico Universitario, Valladolid, Spain (J.F.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosciences (E.L.-C., L.D., M.J., M.H., M.M., S.R., A.S., A.D.) and Biochemistry (A.G., J.B.) and the Magnetic Resonance Unit (A.M.), Hospital Universitari Germans Trias I Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Barcelona, Spain; the Primary Healthcare Research Support Unit Metropolitana Nord, ICS-IDIAP Jordi Gol, Matar\u00f3, Barcelona, Spain (M.T.A.); and the Stroke Unit, Department of Neurology, Hospital Cl\u00ednico Universitario, Valladolid, Spain (J.F.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosciences (E.L.-C., L.D., M.J., M.H., M.M., S.R., A.S., A.D.) and Biochemistry (A.G., J.B.) and the Magnetic Resonance Unit (A.M.), Hospital Universitari Germans Trias I Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Barcelona, Spain; the Primary Healthcare Research Support Unit Metropolitana Nord, ICS-IDIAP Jordi Gol, Matar\u00f3, Barcelona, Spain (M.T.A.); and the Stroke Unit, Department of Neurology, Hospital Cl\u00ednico Universitario, Valladolid, Spain (J.F.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Mill\u00e1n","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosciences (E.L.-C., L.D., M.J., M.H., M.M., S.R., A.S., A.D.) and Biochemistry (A.G., J.B.) and the Magnetic Resonance Unit (A.M.), Hospital Universitari Germans Trias I Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Barcelona, Spain; the Primary Healthcare Research Support Unit Metropolitana Nord, ICS-IDIAP Jordi Gol, Matar\u00f3, Barcelona, Spain (M.T.A.); and the Stroke Unit, Department of Neurology, Hospital Cl\u00ednico Universitario, Valladolid, Spain (J.F.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Revert\u00e9","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosciences (E.L.-C., L.D., M.J., M.H., M.M., S.R., A.S., A.D.) and Biochemistry (A.G., J.B.) and the Magnetic Resonance Unit (A.M.), Hospital Universitari Germans Trias I Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Barcelona, Spain; the Primary Healthcare Research Support Unit Metropolitana Nord, ICS-IDIAP Jordi Gol, Matar\u00f3, Barcelona, Spain (M.T.A.); and the Stroke Unit, Department of Neurology, Hospital Cl\u00ednico Universitario, Valladolid, Spain (J.F.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Su\u00f1ol","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosciences (E.L.-C., L.D., M.J., M.H., M.M., S.R., A.S., A.D.) and Biochemistry (A.G., J.B.) and the Magnetic Resonance Unit (A.M.), Hospital Universitari Germans Trias I Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Barcelona, Spain; the Primary Healthcare Research Support Unit Metropolitana Nord, ICS-IDIAP Jordi Gol, Matar\u00f3, Barcelona, Spain (M.T.A.); and the Stroke Unit, Department of Neurology, Hospital Cl\u00ednico Universitario, Valladolid, Spain (J.F.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Barallat","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosciences (E.L.-C., L.D., M.J., M.H., M.M., S.R., A.S., A.D.) and Biochemistry (A.G., J.B.) and the Magnetic Resonance Unit (A.M.), Hospital Universitari Germans Trias I Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Barcelona, Spain; the Primary Healthcare Research Support Unit Metropolitana Nord, ICS-IDIAP Jordi Gol, Matar\u00f3, Barcelona, Spain (M.T.A.); and the Stroke Unit, Department of Neurology, Hospital Cl\u00ednico Universitario, Valladolid, Spain (J.F.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Massuet","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosciences (E.L.-C., L.D., M.J., M.H., M.M., S.R., A.S., A.D.) and Biochemistry (A.G., J.B.) and the Magnetic Resonance Unit (A.M.), Hospital Universitari Germans Trias I Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Barcelona, Spain; the Primary Healthcare Research Support Unit Metropolitana Nord, ICS-IDIAP Jordi Gol, Matar\u00f3, Barcelona, Spain (M.T.A.); and the Stroke Unit, Department of Neurology, Hospital Cl\u00ednico Universitario, Valladolid, Spain (J.F.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Alzamora","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosciences (E.L.-C., L.D., M.J., M.H., M.M., S.R., A.S., A.D.) and Biochemistry (A.G., J.B.) and the Magnetic Resonance Unit (A.M.), Hospital Universitari Germans Trias I Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Barcelona, Spain; the Primary Healthcare Research Support Unit Metropolitana Nord, ICS-IDIAP Jordi Gol, Matar\u00f3, Barcelona, Spain (M.T.A.); and the Stroke Unit, Department of Neurology, Hospital Cl\u00ednico Universitario, Valladolid, Spain (J.F.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"D\u00e1valos","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosciences (E.L.-C., L.D., M.J., M.H., M.M., S.R., A.S., A.D.) and Biochemistry (A.G., J.B.) and the Magnetic Resonance Unit (A.M.), Hospital Universitari Germans Trias I Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Barcelona, Spain; the Primary Healthcare Research Support Unit Metropolitana Nord, ICS-IDIAP Jordi Gol, Matar\u00f3, Barcelona, Spain (M.T.A.); and the Stroke Unit, Department of Neurology, Hospital Cl\u00ednico Universitario, Valladolid, Spain (J.F.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Francisco","family":"Arenillas","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosciences (E.L.-C., L.D., M.J., M.H., M.M., S.R., A.S., A.D.) and Biochemistry (A.G., J.B.) and the Magnetic Resonance Unit (A.M.), Hospital Universitari Germans Trias I Pujol, Universitat Aut\u00f2noma de Barcelona, Badalona, Barcelona, Spain; the Primary Healthcare Research Support Unit Metropolitana Nord, ICS-IDIAP Jordi Gol, Matar\u00f3, Barcelona, Spain (M.T.A.); and the Stroke Unit, Department of Neurology, Hospital Cl\u00ednico Universitario, Valladolid, Spain (J.F.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.018820"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.505776"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.4.648"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0368-1319(69)80019-0"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000157736.19739.D0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3171\/2009.10.JNS09759"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.50.179"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.15.2003"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/hs1101.098520"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105335"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.01682.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000219299"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2008.06.004"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000168862.09764.9f"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.054403"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.111.620104"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.07.007"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000263186.20988.9f"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000160212"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.498600"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000155620.10387.43"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.110.220673"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.552539"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-11-22"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.12.020"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2010.12.011"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2005.038505"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.192644"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7753(01)72168-9"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2011.09.009"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2005.1.1.69"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000209202.79715.a6"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.03.033"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.108.175299"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.112.661702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:38:32Z","timestamp":1715611112000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.112.661702"}},"subtitle":["The Barcelona-AsIA (Asymptomatic Intracranial Atherosclerosis) Study"],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1161\/STROKEAHA.112.661702"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.112.661702","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"2012-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-06-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-07-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}