{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:13:12Z","timestamp":1792109592339,"version":"4.4.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Preventing cerebral embolisms is a major concern with carotid artery stenting (CAS). This study evaluated 3-dimensional T1-weighted gradient echo (3D T1GRE) sequence to predict cerebral embolism related to CAS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>We performed quantitative analyses of the characteristics of 47 carotid plaques before CAS by measuring the signal intensity ratio (SIR) and plaque volume using 3D T1GRE images. We used T1-weighted turbo field echo sequence to obtain 3D T1GRE images. We also evaluated diffusion-weighted images (DWI) of the brain before and after CAS to detect ischemic lesions (DWI lesions) from cerebral emboli.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              SIR (2.17 [interquartile range 1.50\u20133.07] versus 1.35 [interquartile range 1.08\u20131.97];\n              <jats:italic>P<\/jats:italic>\n              =0.010) and plaque volume (456 mm\n              <jats:sup>3<\/jats:sup>\n              [interquartile range 256\u2013696] versus 301 mm\n              <jats:sup>3<\/jats:sup>\n              [interquartile range 126\u2013433];\n              <jats:italic>P<\/jats:italic>\n              =0.008) were significantly higher in the group of patients positive for DWI lesions (P-group: n=26) than DWI lesion-negative patients (N-group: n=21). In multivariate logistic regression analysis, SIR (\n              <jats:italic>P<\/jats:italic>\n              =0.007) and plaque volume (\n              <jats:italic>P<\/jats:italic>\n              =0.042) were independent predictors of DWI lesions with CAS. Furthermore, SIR (\n              <jats:italic>r<\/jats:italic>\n              s=0.42,\n              <jats:italic>P<\/jats:italic>\n              =0.005) and plaque volume (\n              <jats:italic>r<\/jats:italic>\n              s=0.36,\n              <jats:italic>P<\/jats:italic>\n              =0.012) were positively correlated with the number of DWI lesions. From analysis of a receiver-operating characteristic curve, the most reliable cutoff values of SIR and plaque volume to predict DWI lesions related to CAS were 1.80 and 373 mm\n              <jats:sup>3<\/jats:sup>\n              , respectively.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Quantitative evaluation of carotid plaques using 3D T1GRE images may be useful in predicting cerebral embolism related to CAS.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.112.663138","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T07:02:27Z","timestamp":1353481347000},"page":"105-110","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":42,"title":["High-Risk Plaque for Carotid Artery Stenting Evaluated With 3-Dimensional T1-Weighted Gradient Echo Sequence"],"prefix":"10.1161","volume":"44","author":[{"given":"Hiroshi","family":"Tanemura","sequence":"first","affiliation":[{"name":"From the Departments of Neurosurgery (H.T., Y.M., Y.U., S.H., N.T., F.A., H.Suzuki, S.M., W.T.), Radiology (M.M.), and Innovative Neuro-Intervention Radiology (H.Sakaida), Mie University Graduate School of Medicine, Tsu, Mie, Japan; and the Department of Neurosurgery, Saiseikai Matsusaka General Hospital, Matsusaka, Mie, Japan (N.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Maeda","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery (H.T., Y.M., Y.U., S.H., N.T., F.A., H.Suzuki, S.M., W.T.), Radiology (M.M.), and Innovative Neuro-Intervention Radiology (H.Sakaida), Mie University Graduate School of Medicine, Tsu, Mie, Japan; and the Department of Neurosurgery, Saiseikai Matsusaka General Hospital, Matsusaka, Mie, Japan (N.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery (H.T., Y.M., Y.U., S.H., N.T., F.A., H.Suzuki, S.M., W.T.), Radiology (M.M.), and Innovative Neuro-Intervention Radiology (H.Sakaida), Mie University Graduate School of Medicine, Tsu, Mie, Japan; and the Department of Neurosurgery, Saiseikai Matsusaka General Hospital, Matsusaka, Mie, Japan (N.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Miura","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery (H.T., Y.M., Y.U., S.H., N.T., F.A., H.Suzuki, S.M., W.T.), Radiology (M.M.), and Innovative Neuro-Intervention Radiology (H.Sakaida), Mie University Graduate School of Medicine, Tsu, Mie, Japan; and the Department of Neurosurgery, Saiseikai Matsusaka General Hospital, Matsusaka, Mie, Japan (N.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Umeda","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery (H.T., Y.M., Y.U., S.H., N.T., F.A., H.Suzuki, S.M., W.T.), Radiology (M.M.), and Innovative Neuro-Intervention Radiology (H.Sakaida), Mie University Graduate School of Medicine, Tsu, Mie, Japan; and the Department of Neurosurgery, Saiseikai Matsusaka General Hospital, Matsusaka, Mie, Japan (N.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Hatazaki","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery (H.T., Y.M., Y.U., S.H., N.T., F.A., H.Suzuki, S.M., W.T.), Radiology (M.M.), and Innovative Neuro-Intervention Radiology (H.Sakaida), Mie University Graduate School of Medicine, Tsu, Mie, Japan; and the Department of Neurosurgery, Saiseikai Matsusaka General Hospital, Matsusaka, Mie, Japan (N.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Toma","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery (H.T., Y.M., Y.U., S.H., N.T., F.A., H.Suzuki, S.M., W.T.), Radiology (M.M.), and Innovative Neuro-Intervention Radiology (H.Sakaida), Mie University Graduate School of Medicine, Tsu, Mie, Japan; and the Department of Neurosurgery, Saiseikai Matsusaka General Hospital, Matsusaka, Mie, Japan (N.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Asakura","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery (H.T., Y.M., Y.U., S.H., N.T., F.A., H.Suzuki, S.M., W.T.), Radiology (M.M.), and Innovative Neuro-Intervention Radiology (H.Sakaida), Mie University Graduate School of Medicine, Tsu, Mie, Japan; and the Department of Neurosurgery, Saiseikai Matsusaka General Hospital, Matsusaka, Mie, Japan (N.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Suzuki","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery (H.T., Y.M., Y.U., S.H., N.T., F.A., H.Suzuki, S.M., W.T.), Radiology (M.M.), and Innovative Neuro-Intervention Radiology (H.Sakaida), Mie University Graduate School of Medicine, Tsu, Mie, Japan; and the Department of Neurosurgery, Saiseikai Matsusaka General Hospital, Matsusaka, Mie, Japan (N.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Sakaida","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery (H.T., Y.M., Y.U., S.H., N.T., F.A., H.Suzuki, S.M., W.T.), Radiology (M.M.), and Innovative Neuro-Intervention Radiology (H.Sakaida), Mie University Graduate School of Medicine, Tsu, Mie, Japan; and the Department of Neurosurgery, Saiseikai Matsusaka General Hospital, Matsusaka, Mie, Japan (N.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Matsushima","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery (H.T., Y.M., Y.U., S.H., N.T., F.A., H.Suzuki, S.M., W.T.), Radiology (M.M.), and Innovative Neuro-Intervention Radiology (H.Sakaida), Mie University Graduate School of Medicine, Tsu, Mie, Japan; and the Department of Neurosurgery, Saiseikai Matsusaka General Hospital, Matsusaka, Mie, Japan (N.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waro","family":"Taki","sequence":"additional","affiliation":[{"name":"From the Departments of Neurosurgery (H.T., Y.M., Y.U., S.H., N.T., F.A., H.Suzuki, S.M., W.T.), Radiology (M.M.), and Innovative Neuro-Intervention Radiology (H.Sakaida), Mie University Graduate School of Medicine, Tsu, Mie, Japan; and the Department of Neurosurgery, Saiseikai Matsusaka General Hospital, Matsusaka, Mie, Japan (N.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912321"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.500603"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.106.473066"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20060"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000204638.91099.91"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2491071517"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000028591.44554.f9"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000125856.25309.86"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/hs1101.098663"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3171\/2010.3.JNS091057"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000074222.61572.44"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000074204.92443.37"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000149867.61851.31"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3171\/JNS.2008.109.12.1042"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.106.479139"},{"key":"e_1_3_2_17_2","first-page":"287","article-title":"Association between signal hyperintensity on T1-weighted MR imaging of carotid plaques and ipsilateral ischemic events.","volume":"28","author":"Yamada N","year":"2007","unstructured":"Yamada N, Higashi M, Otsubo R, Sakuma T, Oyama N, Tanaka R, et al.. 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