{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:50:09Z","timestamp":1789901409333,"version":"4.0.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Coronary heart disease (CHD) is a major cause of mortality among stroke patients after the acute period. Simple risk stratification of stroke patients without known CHD may permit prompt implementation of CHD-specific management strategies for those who are at high risk for cardiac events. We assessed the utility of the Framingham Coronary Heart Disease Risk Score (FCRS) as a prognosticator in stroke patients without known CHD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Post hoc analysis of a trial dataset of 3509 recent ischemic stroke patients who were aged 35 years or older, recruited from 56 centers, and followed-up for 2 years. Patients were categorized as having known CHD, high FCRS (\u226520%), and low\/intermediate FCRS (&lt;20%). The predictive values between baseline FCRS and primary (myocardial infarction [MI]), secondary (MI or vascular death), and tertiary (recurrent stroke) outcomes were assessed in multivariate analyses.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>Rates of first MI at 2 years were 6.34%, 4.65%, and 1.44% for the known CHD, high FCRS, and low\/intermediate FCRS groups. Compared with stroke patients with low\/intermediate FCRS, individuals with high FCRS had a higher risk of MI (adjusted hazard ratio, 3.70; 95% confidence interval, 2.14\u20136.38) and MI or vascular death (adjusted hazard ratio, 2.21; 95% confidence interval, 1.48\u20133.28). High FCRS did not predict recurrent stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>Among patients with a recent ischemic stroke without known CHD, high FCRS was associated with a higher risk of MI and vascular death, but not stroke. FCRS could be a simple way to identify recent stroke patients who may benefit from additional CHD-specific management.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.112.668319","type":"journal-article","created":{"date-parts":[[2012,9,5]],"date-time":"2012-09-05T01:02:49Z","timestamp":1346806969000},"page":"2942-2947","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Utility of Framingham Coronary Heart Disease Risk Score for Predicting Cardiac Risk After Stroke"],"prefix":"10.1161","volume":"43","author":[{"given":"Amytis","family":"Towfighi","sequence":"first","affiliation":[{"name":"From the Department of Neurology, University of Southern California, Los Angeles, (A.T.); Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Los Angeles, CA (A.T.); Department of Biomathematics, University of California, Los Angeles, (D.M.); Department of Neurosciences Medical University of South Carolina, Charleston, SC (B.O)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Markovic","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, University of Southern California, Los Angeles, (A.T.); Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Los Angeles, CA (A.T.); Department of Biomathematics, University of California, Los Angeles, (D.M.); Department of Neurosciences Medical University of South Carolina, Charleston, SC (B.O)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Ovbiagele","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, University of Southern California, Los Angeles, (A.T.); Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Los Angeles, CA (A.T.); Department of Biomathematics, University of California, Los Angeles, (D.M.); Department of Neurosciences Medical University of South Carolina, Charleston, SC (B.O)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.110.584086"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000201253.93811.f6"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.9.2080"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000190118.02275.33"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.106.25.3143"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.106.480988"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.921072"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.491258"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.487223"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31823ac046"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000219299"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2007.00136.x"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.109.564781"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e31825bcdac"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.060110"},{"key":"e_1_3_4_17_2","first-page":"CD002003","article-title":"Beta-blockers for hypertension.","author":"Wiysonge CS","year":"2007","unstructured":"Wiysonge CS, Bradley H, Mayosi BM, Maroney R, Mbewu A, Opie LH, et al.. 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