{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:41:47Z","timestamp":1792690907238,"version":"4.5.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Hemodynamic properties of brain arteriovenous malformations (AVMs) with risk factors for a future hemorrhage are essentially unknown. We hypothesized that AVMs with anatomic properties, which are associated with an increased rupture risk, exhibit different hemodynamic characteristics than those without these properties.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Seventy-two consecutive patients with AVMs diagnosed by conventional angiography underwent MRI examination, including time-resolved 3-dimensional MR angiography. Signal-intensity curves derived from the time-resolved 3-dimensional MR angiography datasets were used to calculate relative blood flow transit times through the AVM nidus based on the time-to-peak parameter. For identification of characteristics associated with altered transit times, a multiple normal regression model was fitted with stepwise selection of the following regressors: intracranial hemorrhage, deep nidus location, infratentorial location, deep drainage, associated aneurysm, nidus size, draining venous stenosis, and number of draining veins.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              A previous intracranial hemorrhage is the only characteristic that was associated with a significant alteration of the relative transit time, leading to an increase of 2.4 seconds (95% CI, 1.2\u20133.6 seconds;,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) without adjustment and 2.1 seconds (95% CI, 0.6\u20133.6 seconds;\n              <jats:italic>P<\/jats:italic>\n              =0.007) with adjustment for all other regressors considered. The association was independent of the bleeding age.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>Hemodynamic parameters do not seem useful for risk assessment of an AVM-related hemorrhage because only a previous AVM rupture leads to a significant and permanent alteration of the hemodynamic situation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.112.669945","type":"journal-article","created":{"date-parts":[[2012,10,22]],"date-time":"2012-10-22T20:59:33Z","timestamp":1350939573000},"page":"2910-2915","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":47,"title":["Persistent Hemodynamic Changes in Ruptured Brain Arteriovenous Malformations"],"prefix":"10.1161","volume":"43","author":[{"given":"Till","family":"Illies","sequence":"first","affiliation":[{"name":"From the Departments of Diagnostic and Interventional Neuroradiology (T.I., K.W., T.R., J.F.), Computational Neuroscience (N.D.F., D.S.), Neurosurgery (J.R.), and Medical Biometry and Epidemiology (K.W.), University Hospital Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils Daniel","family":"Forkert","sequence":"additional","affiliation":[{"name":"From the Departments of Diagnostic and Interventional Neuroradiology (T.I., K.W., T.R., J.F.), Computational Neuroscience (N.D.F., D.S.), Neurosurgery (J.R.), and Medical Biometry and Epidemiology (K.W.), University Hospital Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Saering","sequence":"additional","affiliation":[{"name":"From the Departments of Diagnostic and Interventional Neuroradiology (T.I., K.W., T.R., J.F.), Computational Neuroscience (N.D.F., D.S.), Neurosurgery (J.R.), and Medical Biometry and Epidemiology (K.W.), University Hospital Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolin","family":"Wenzel","sequence":"additional","affiliation":[{"name":"From the Departments of Diagnostic and Interventional Neuroradiology (T.I., K.W., T.R., J.F.), Computational Neuroscience (N.D.F., D.S.), Neurosurgery (J.R.), and Medical Biometry and Epidemiology (K.W.), University Hospital Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Ries","sequence":"additional","affiliation":[{"name":"From the Departments of Diagnostic and Interventional Neuroradiology (T.I., K.W., T.R., J.F.), Computational Neuroscience (N.D.F., D.S.), Neurosurgery (J.R.), and Medical Biometry and Epidemiology (K.W.), University Hospital Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Regelsberger","sequence":"additional","affiliation":[{"name":"From the Departments of Diagnostic and Interventional Neuroradiology (T.I., K.W., T.R., J.F.), Computational Neuroscience (N.D.F., D.S.), Neurosurgery (J.R.), and Medical Biometry and Epidemiology (K.W.), University Hospital Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Wegscheider","sequence":"additional","affiliation":[{"name":"From the Departments of Diagnostic and Interventional Neuroradiology (T.I., K.W., T.R., J.F.), Computational Neuroscience (N.D.F., D.S.), Neurosurgery (J.R.), and Medical Biometry and Epidemiology (K.W.), University Hospital Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Fiehler","sequence":"additional","affiliation":[{"name":"From the Departments of Diagnostic and Interventional Neuroradiology (T.I., K.W., T.R., J.F.), Computational Neuroscience (N.D.F., D.S.), Neurosurgery (J.R.), and Medical Biometry and Epidemiology (K.W.), University Hospital 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