{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:10:14Z","timestamp":1785499814014,"version":"3.56.0"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>\n              Hypothermia induced after perinatal hypoxia\u2013ischemia is partially protective. This study examined whether early treatment with the noncompetitive N-methyl\n              <jats:sc>-d-<\/jats:sc>\n              aspartate receptor antagonist, dizocilpine, can augment neuroprotection with delayed hypothermia after severe asphyxia in preterm fetal sheep at 0.7 weeks gestation (equivalent to 28\u201332 weeks in humans).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Fifty minutes after umbilical cord occlusion for 25 minutes, fetuses were randomized to either dizocilpine (2 mg\/kg estimated fetal weight intravenously, then 0.07 mg\/kg\/h for 4 hours) and then after 5.5 hours to whole-body cooling to 3\u00b0C below baseline, or sham cooling, until 72 hours, and euthanized 7 days after umbilical cord occlusion.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Delayed hypothermia was associated with improved neuronal survival (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.02) and reduced microglia (\n              <jats:italic>P<\/jats:italic>\n              =0.004) and caspase-3-positive cells (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01) compared with umbilical cord occlusion. Dizocilpine was associated with reduced microglia (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) but no effect on caspase-3 induction and improved survival only in CA1\/2 (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) with no apparent additive effect with delayed hypothermia.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              Early N-methyl\n              <jats:sc>-d-<\/jats:sc>\n              aspartate blockade and a clinical regime of delayed whole-body hypothermia provide nonadditive neuroprotection in the preterm brain.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.112.671982","type":"journal-article","created":{"date-parts":[[2012,8,25]],"date-time":"2012-08-25T00:14:59Z","timestamp":1345853699000},"page":"3114-3117","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Nonadditive Neuroprotection With Early Glutamate Receptor Blockade and Delayed Hypothermia After Asphyxia in Preterm Fetal Sheep"],"prefix":"10.1161","volume":"43","author":[{"given":"Sherly A.","family":"George","sequence":"first","affiliation":[{"name":"From the University of Auckland, Auckland, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Barrett","sequence":"additional","affiliation":[{"name":"From the University of Auckland, Auckland, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bennet","sequence":"additional","affiliation":[{"name":"From the University of Auckland, Auckland, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Mathai","sequence":"additional","affiliation":[{"name":"From the University of Auckland, Auckland, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen C.","family":"Jensen","sequence":"additional","affiliation":[{"name":"From the University of Auckland, Auckland, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair J.","family":"Gunn","sequence":"additional","affiliation":[{"name":"From the University of Auckland, Auckland, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","unstructured":"Committee on Understanding Premature Birth and Assuring Healthy Outcomes. Preterm birth: causes consequences and prevention. Available at: http:\/\/books.nap.edu\/\/catalog\/11622.html#toc. Institute of Medicine The National Academies Press; 2007. Accessed June 1 2010."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c363"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000128029.50221.fa"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181d4ff4d"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901350302"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2005.10.017"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurx.2006.01.007"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.5.713"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000244109"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21121"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.112.671982","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:14:00Z","timestamp":1715609640000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.112.671982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1161\/STROKEAHA.112.671982"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.112.671982","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11]]},"assertion":[{"value":"2012-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-07-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-08-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}