{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:23:01Z","timestamp":1778628181930,"version":"3.51.4"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Prominent posterior cerebral artery (PCA) laterality upon 3-dimensional time-of-flight magnetic resonance angiography is often encountered in patients with middle cerebral artery occlusion. We hypothesized that this sign is correlated with improved functional outcome in patients with middle cerebral artery occlusion treated with intravenous recombinant tissue plasminogen activator.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Fifty acute ischemic stroke patients with middle cerebral artery occlusion were treated with intravenous recombinant tissue plasminogen activator from April 2007 to October 2009. All patients routinely underwent initial (first 3 hours) magnetic resonance scans on admission, and additional follow-up (14\u201321 days after stroke onset) computed tomography scans. Two film readers blinded to all clinical information assessed the presence or absence of PCA laterality on magnetic resonance angiography. We retrospectively analyzed the clinical and radiologic data on all patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Out of 50 patients, 20 showed PCA laterality on magnetic resonance angiography. National Institute of Health Stroke Scale score 7 days after stroke onset was significantly lower (\n              <jats:italic>P<\/jats:italic>\n              =0.007), and infarct volume on follow-up computed tomography was significantly smaller (\n              <jats:italic>P<\/jats:italic>\n              =0.009) in patients with PCA laterality than in patients without this sign. Multivariate logistic regression analyses showed an adjusted odds ratio of 8.49 for a favorable outcome (modified Rankin Scale score 0\u20131 at 6 months) in patients with PCA laterality (95% CI: 1.82 to 55.8,\n              <jats:italic>P<\/jats:italic>\n              =0.005).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>The presence of PCA laterality on magnetic resonance angiography before intravenous recombinant tissue plasminogen activator can be used as a predictor of favorable functional outcome in patients with middle cerebral artery occlusion, probably due to improvement of recanalization rate.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.112.674101","type":"journal-article","created":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T01:54:44Z","timestamp":1354154084000},"page":"512-515","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Posterior Cerebral Artery Laterality on Magnetic Resonance Angiography Predicts Long-Term Functional Outcome in Middle Cerebral Artery Occlusion"],"prefix":"10.1161","volume":"44","author":[{"given":"Masahiko","family":"Ichijo","sequence":"first","affiliation":[{"name":"From the Department of Neurology and Neurological Science (M.I., S.I., H.M.); Department of Endovascular Surgery (K.M.), and Clinical Research Center (M.T.), Center for Brain Integration Research, Tokyo Medical and Dental University, Tokyo, Japan; Department of Neurology, Musashino Red Cross Hospital, Tokyo, Japan (T.K.); and Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan (H.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Miki","sequence":"additional","affiliation":[{"name":"From the Department of Neurology and Neurological Science (M.I., S.I., H.M.); Department of Endovascular Surgery (K.M.), and Clinical Research Center (M.T.), Center for Brain Integration Research, Tokyo Medical and Dental University, Tokyo, Japan; Department of Neurology, Musashino Red Cross Hospital, Tokyo, Japan (T.K.); and Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan (H.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Ishibashi","sequence":"additional","affiliation":[{"name":"From the Department of Neurology and Neurological Science (M.I., S.I., H.M.); Department of Endovascular Surgery (K.M.), and Clinical Research Center (M.T.), Center for Brain Integration Research, Tokyo Medical and Dental University, Tokyo, Japan; Department of Neurology, Musashino Red Cross Hospital, Tokyo, Japan (T.K.); and Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan (H.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Tomita","sequence":"additional","affiliation":[{"name":"From the Department of Neurology and Neurological Science (M.I., S.I., H.M.); Department of Endovascular Surgery (K.M.), and Clinical Research Center (M.T.), Center for Brain Integration Research, Tokyo Medical and Dental University, Tokyo, Japan; Department of Neurology, Musashino Red Cross Hospital, Tokyo, Japan (T.K.); and Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan (H.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Kamata","sequence":"additional","affiliation":[{"name":"From the Department of Neurology and Neurological Science (M.I., S.I., H.M.); Department of Endovascular Surgery (K.M.), and Clinical Research Center (M.T.), Center for Brain Integration Research, Tokyo Medical and Dental University, Tokyo, Japan; Department of Neurology, Musashino Red Cross Hospital, Tokyo, Japan (T.K.); and Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan (H.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Fujigasaki","sequence":"additional","affiliation":[{"name":"From the Department of Neurology and Neurological Science (M.I., S.I., H.M.); Department of Endovascular Surgery (K.M.), and Clinical Research Center (M.T.), Center for Brain Integration Research, Tokyo Medical and Dental University, Tokyo, Japan; Department of Neurology, Musashino Red Cross Hospital, Tokyo, Japan (T.K.); and Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan (H.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiro","family":"Mizusawa","sequence":"additional","affiliation":[{"name":"From the Department of Neurology and Neurological Science (M.I., S.I., H.M.); Department of Endovascular Surgery (K.M.), and Clinical Research Center (M.T.), Center for Brain Integration Research, Tokyo Medical and Dental University, Tokyo, Japan; Department of Neurology, Musashino Red Cross Hospital, Tokyo, Japan (T.K.); and Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan (H.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.109.561787"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70195-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.132100"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp155"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.110.592303"},{"key":"e_1_3_2_7_2","first-page":"88","article-title":"Prominent laterality of the posterior cerebral artery at three-dimensional time-of-flight MR angiography in M1-segment middle cerebral artery occlusion.","volume":"25","author":"Uemura A","year":"2004","unstructured":"Uemura A, O\u2019uchi T, Kikuchi Y, Yashiro N, Ihara N, Shoji K. Prominent laterality of the posterior cerebral artery at three-dimensional time-of-flight MR angiography in M1-segment middle cerebral artery occlusion. AJNR Am J Neuroradiol. 2004;25:88\u201391.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02237-6"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.110.595256"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.112.674101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:05:29Z","timestamp":1715609129000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.112.674101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1161\/STROKEAHA.112.674101"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.112.674101","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"2012-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-11-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}