{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:27:12Z","timestamp":1791548832264,"version":"4.3.4"},"reference-count":61,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Established predictors of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage are large amounts of extravasated blood and poor clinical condition on admission. The predictive value of other factors is uncertain.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>We searched MEDLINE (1960\u20132012) for clinical, laboratory, and radiological predictors routinely available within 72 hours after subarachnoid hemorrhage. The studies were categorized according to methodological quality. Crude data and effect estimates (odds ratio [OR], hazard ratios, and risk ratio) with 95% CI were extracted, (re-)calculated and pooled if possible. For every potential predictor we assessed all effect estimates on consistency (point estimates in equal direction) and clinical relevance (size and 95% CI).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>Fifty-two studies on 33 potential predictors were included. There was strong evidence (\u22653 high-quality studies) for a higher risk of delayed cerebral ischemia in smokers (pooled OR, 1.2; 95% CI, 1.1\u20131.4), and moderate evidence (2 high-quality studies) for an increased risk in patients with hyperglycemia (OR, 3.2; 1.8\u20135.8 and hazard ratios, 1.7; 1.1\u20132.5), hydrocephalus (OR, 1.3; 1.1\u20131.5 and OR, 2.6; 1.2\u20135.5), history of diabetes mellitus (pooled OR, 6.7; 1.7\u201326), and early systemic inflammatory response syndrome (pooled OR, 2.1; 1.4\u20133.3). Evidence was limited for increased risk in women (pooled OR, 1.3; 1.1\u20131.6) and in patients with history of hypertension (pooled OR, 1.5; 1.3\u20131.7). The evidence on initial loss of consciousness, history of migraine, previous use of selective serotonin reuptake inhibitors, hypomagnesemia, low hemoglobin, or high blood flow on early transcranial Doppler was also limited.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>There is strong evidence that smoking is a predictor of delayed cerebral ischemia. For several other potential predictions the evidence is moderate, limited, or inconsistent.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.112.674291","type":"journal-article","created":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T04:55:18Z","timestamp":1355892918000},"page":"43-54","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":175,"title":["Delayed Cerebral Ischemia After Subarachnoid Hemorrhage"],"prefix":"10.1161","volume":"44","author":[{"given":"Nicolien K.","family":"de Rooij","sequence":"first","affiliation":[{"name":"From the Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands (N.K.d.R., G.J.E.R., C.J.M.F.); and the Department of Radiology, University Medical Center Utrecht, the Netherlands (J.W.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel J.E.","family":"Rinkel","sequence":"additional","affiliation":[{"name":"From the Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands (N.K.d.R., G.J.E.R., C.J.M.F.); and the Department of Radiology, University Medical Center Utrecht, the Netherlands (J.W.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Willem","family":"Dankbaar","sequence":"additional","affiliation":[{"name":"From the Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands (N.K.d.R., G.J.E.R., C.J.M.F.); and the Department of Radiology, University Medical Center Utrecht, the Netherlands (J.W.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina J.M.","family":"Frijns","sequence":"additional","affiliation":[{"name":"From the Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, the Netherlands (N.K.d.R., G.J.E.R., C.J.M.F.); and the Department of Radiology, University Medical Center Utrecht, the Netherlands (J.W.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.68.3.337"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60153-6"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.10.1586"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198001000-00001"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21537"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.323.7306.224"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(98)00058-X"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2010.05.006"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.10.1404"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000168054.60538.2B"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.484220"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000214222"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.7.1402"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1385\/NCC:1:4:441"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/hs1001.097041"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-008-9054-2"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.01980.x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-009-9232-x"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1997.86.4.0594"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.10.1250"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000185632.69374.C9"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.11.2268"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.99.2.0271"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(91)90224-W"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1159\/000314623"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2009.07.001"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2009.46.2.99"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.304.6843.1663"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1995.82.6.0945"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-011-1243-7"},{"key":"e_1_3_3_32_2","article-title":"Age-Associated Vasospasm in Aneurysmal Subarachnoid Hemorrhage.","author":"Kale SP","year":"2011","unstructured":"Kale SP, Edgell RC, Alshekhlee A, Haghighi AB, Sweeny J, Felton J, et al.. Age-Associated Vasospasm in Aneurysmal Subarachnoid Hemorrhage. J Stroke Cerebrovasc Dis. June 28, 2011. doi:10.1016\/j.jstrokecerebrovasdis.2011.05.024. Accessed June 28, 2011.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1179\/016164107X248983"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1996.84.1.0043"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.12.2617"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000290892.46954.12"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.142034"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1996.85.3.0410"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1997.87.3.0381"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.99.4.0644"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.3171\/2009.9.JNS081670"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.105.5.671"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2007.12.027"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000232662.86771.A9"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.37.881"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000153925.96889.8A"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000133132.76983.8e"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ana.0000181693.30750.af"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e3181ed11ab"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000166536.42876.9C"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-006-0808-3"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1159\/000324938"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000154523.21633.0E"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2004.101.6.0921"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000043984.42487.0E"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-006-0863-9"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1998.89.3.0405"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1161\/hs0901.095646"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-010-9408-4"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.180349"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000156644.45384.92"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1984.04050210031009"}],"updated-by":[{"DOI":"10.1161\/str.0b013e318286ba6d","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000}}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.112.674291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:10:14Z","timestamp":1715609414000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.112.674291"}},"subtitle":["A Systematic Review of Clinical, Laboratory, and Radiological Predictors"],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1161\/STROKEAHA.112.674291"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.112.674291","relation":{"correction":[{"id-type":"doi","id":"10.1161\/STR.0b013e318286ba6d","asserted-by":"object"}]},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"2012-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}