{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:06:11Z","timestamp":1791295571580,"version":"4.1.0"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Clinical significance of silent microbleeds is unknown in moyamoya disease. This study was aimed to clarify the incidence, locations, and longitudinal course.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>This prospective cohort study included 78 nontreated patients with moyamoya disease. The incidence and locations of silent microbleeds were evaluated on T2*-weighted MRI. MR examinations were repeated every 6 or 12 months during a mean follow-up period of 43.1 months.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              T2*-weighted MRI identified silent microbleeds in 17 (29.3%) of 58 adult patients with moyamoya disease, but in none of 20 pediatric patients. During follow-up periods, de novo silent microbleeds developed in 4 (6.9%) of 58 adult patients. Hemorrhagic stroke occurred in 4 patients (6.9%), all of who had silent microbleeds on initial examination. The presence of silent microbleeds was a significant predictor for subsequent hemorrhagic stroke in adult moyamoya disease (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Careful and long-term follow-up of silent microbleeds would be essential to improve their outcome in adult patients with moyamoya disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.112.678805","type":"journal-article","created":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T07:11:14Z","timestamp":1354864274000},"page":"516-518","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["Incidence, Locations, and Longitudinal Course of Silent Microbleeds in Moyamoya Disease"],"prefix":"10.1161","volume":"44","author":[{"given":"Satoshi","family":"Kuroda","sequence":"first","affiliation":[{"name":"From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daina","family":"Kashiwazaki","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Nakayama","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyohiro","family":"Houkin","sequence":"additional","affiliation":[{"name":"From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70240-0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01411056"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-8467(97)00080-2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.45.495"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.102.3.0470"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000311067.41239.E6"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000369606.00861.91"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.112.678805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:05:39Z","timestamp":1715609139000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.112.678805"}},"subtitle":["A Prospective T2*-Weighted MRI Study"],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1161\/STROKEAHA.112.678805"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.112.678805","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"2012-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-12-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}