{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:52:04Z","timestamp":1790693524292,"version":"4.1.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>To compare potential risk factors, clinical symptoms, diagnostic delay, and 3-month outcome between spontaneous internal carotid artery dissection (sICAD) and spontaneous vertebral artery dissection (sVAD).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>We compared patients with sICAD (n=668) and sVAD (n=302) treated in 3 university hospitals.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Patients with sICAD were older (46.3\u00b19.6 versus 42.0\u00b110.2 years;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), more often men (62.7% versus 53.0%;\n              <jats:italic>P<\/jats:italic>\n              =0.004), and presented more frequently with tinnitus (10.9% versus 3.4%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and more severe ischemic strokes (median National Institute\n              <jats:bold>s<\/jats:bold>\n              of Health Stroke Scale, 10\u00b17.1 versus 5\u00b15.9;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Patients with sVAD had more often bilateral dissections (15.2% versus 7.6%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and were more often smokers (36.0% versus 28.7%;\n              <jats:italic>P<\/jats:italic>\n              =0.007). Thunderclap headache (9.2% versus 3.6%;\n              <jats:italic>P<\/jats:italic>\n              =0.001) and neck pain were more common (65.8% versus 33.5%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) in sVAD. Subarachnoid hemorrhage (6.0% versus 0.6%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and ischemic stroke (69.5% versus 52.2%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) were more frequent in sVAD. After multivariate analysis, sex difference lost its significance (\n              <jats:italic>P<\/jats:italic>\n              =0.21), and all other variables remained significant. Time to diagnosis was similar in sICAD and sVAD and improved between 2001 and 2012 compared with the previous 10-year period (8.0\u00b110.5 days versus 10.7\u00b113.2 days;\n              <jats:italic>P<\/jats:italic>\n              =0.004). In sVAD, favorable outcome 3 months after ischemic stroke (modified Rankin Scale, 0\u20132: 88.8% versus 58.4%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), recurrent transient ischemic attack (4.8% versus 1.1%;\n              <jats:italic>P<\/jats:italic>\n              =0.001), and recurrent ischemic stroke (2.8% versus 0.7%;\n              <jats:italic>P<\/jats:italic>\n              =0.02) within 3 months were more frequent.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>sICAD and sVAD patients differ in many aspects. Future studies should perform separate analyses of these 2 entities.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.113.001057","type":"journal-article","created":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T21:41:33Z","timestamp":1367444493000},"page":"1537-1542","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":106,"title":["Differences and Similarities Between Spontaneous Dissections of the Internal Carotid Artery and the Vertebral Artery"],"prefix":"10.1161","volume":"44","author":[{"given":"Michelle","family":"von Babo","sequence":"first","affiliation":[{"name":"From the Department of Neurology (M.v.B., G.M.D.M., H.S., U.F., M.R.H., S.J., B.G.S., H.P.M., M.A.) and Neuroradiology (J.G.), University Hospital of Bern, Bern\u00b8 Switzerland; Department of Neurology, University Hospital Zurich, Zurich, Switzerland (H.S., R.W.B.); and Department of Neurology, H\u00f4pital Lariboisi\u00e8re, APHP, Universit\u00e9 Paris-Diderot, Paris, France (C.S., F.B., M.-G.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Marco","family":"De Marchis","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.v.B., G.M.D.M., H.S., U.F., M.R.H., S.J., B.G.S., H.P.M., M.A.) and Neuroradiology (J.G.), University Hospital of Bern, Bern\u00b8 Switzerland; Department of Neurology, University Hospital Zurich, Zurich, Switzerland (H.S., R.W.B.); and Department of Neurology, H\u00f4pital Lariboisi\u00e8re, APHP, Universit\u00e9 Paris-Diderot, Paris, France (C.S., F.B., M.-G.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Sarikaya","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.v.B., G.M.D.M., H.S., U.F., M.R.H., S.J., B.G.S., H.P.M., M.A.) and Neuroradiology (J.G.), University Hospital of Bern, Bern\u00b8 Switzerland; Department of Neurology, University Hospital Zurich, Zurich, Switzerland (H.S., R.W.B.); and Department of Neurology, H\u00f4pital Lariboisi\u00e8re, APHP, Universit\u00e9 Paris-Diderot, Paris, France (C.S., F.B., M.-G.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Stapf","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.v.B., G.M.D.M., H.S., U.F., M.R.H., S.J., B.G.S., H.P.M., M.A.) and Neuroradiology (J.G.), University Hospital of Bern, Bern\u00b8 Switzerland; Department of Neurology, University Hospital Zurich, Zurich, Switzerland (H.S., R.W.B.); and Department of Neurology, H\u00f4pital Lariboisi\u00e8re, APHP, Universit\u00e9 Paris-Diderot, Paris, France (C.S., F.B., M.-G.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9derique","family":"Buffon","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.v.B., G.M.D.M., H.S., U.F., M.R.H., S.J., B.G.S., H.P.M., M.A.) and Neuroradiology (J.G.), University Hospital of Bern, Bern\u00b8 Switzerland; Department of Neurology, University Hospital Zurich, Zurich, Switzerland (H.S., R.W.B.); and Department of Neurology, H\u00f4pital Lariboisi\u00e8re, APHP, Universit\u00e9 Paris-Diderot, Paris, France (C.S., F.B., M.-G.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Fischer","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.v.B., G.M.D.M., H.S., U.F., M.R.H., S.J., B.G.S., H.P.M., M.A.) and Neuroradiology (J.G.), University Hospital of Bern, Bern\u00b8 Switzerland; Department of Neurology, University Hospital Zurich, Zurich, Switzerland (H.S., R.W.B.); and Department of Neurology, H\u00f4pital Lariboisi\u00e8re, APHP, Universit\u00e9 Paris-Diderot, Paris, France (C.S., F.B., M.-G.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam R.","family":"Heldner","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.v.B., G.M.D.M., H.S., U.F., M.R.H., S.J., B.G.S., H.P.M., M.A.) and Neuroradiology (J.G.), University Hospital of Bern, Bern\u00b8 Switzerland; Department of Neurology, University Hospital Zurich, Zurich, Switzerland (H.S., R.W.B.); and Department of Neurology, H\u00f4pital Lariboisi\u00e8re, APHP, Universit\u00e9 Paris-Diderot, Paris, France (C.S., F.B., M.-G.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Gralla","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.v.B., G.M.D.M., H.S., U.F., M.R.H., S.J., B.G.S., H.P.M., M.A.) and Neuroradiology (J.G.), University Hospital of Bern, Bern\u00b8 Switzerland; Department of Neurology, University Hospital Zurich, Zurich, Switzerland (H.S., R.W.B.); and Department of Neurology, H\u00f4pital Lariboisi\u00e8re, APHP, Universit\u00e9 Paris-Diderot, Paris, France (C.S., F.B., M.-G.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Jung","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.v.B., G.M.D.M., H.S., U.F., M.R.H., S.J., B.G.S., H.P.M., M.A.) and Neuroradiology (J.G.), University Hospital of Bern, Bern\u00b8 Switzerland; Department of Neurology, University Hospital Zurich, Zurich, Switzerland (H.S., R.W.B.); and Department of Neurology, H\u00f4pital Lariboisi\u00e8re, APHP, Universit\u00e9 Paris-Diderot, Paris, France (C.S., F.B., M.-G.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara Goeggel","family":"Simonetti","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.v.B., G.M.D.M., H.S., U.F., M.R.H., S.J., B.G.S., H.P.M., M.A.) and Neuroradiology (J.G.), University Hospital of Bern, Bern\u00b8 Switzerland; Department of Neurology, University Hospital Zurich, Zurich, Switzerland (H.S., R.W.B.); and Department of Neurology, H\u00f4pital Lariboisi\u00e8re, APHP, Universit\u00e9 Paris-Diderot, Paris, France (C.S., F.B., M.-G.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich P.","family":"Mattle","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.v.B., G.M.D.M., H.S., U.F., M.R.H., S.J., B.G.S., H.P.M., M.A.) and Neuroradiology (J.G.), University Hospital of Bern, Bern\u00b8 Switzerland; Department of Neurology, University Hospital Zurich, Zurich, Switzerland (H.S., R.W.B.); and Department of Neurology, H\u00f4pital Lariboisi\u00e8re, APHP, Universit\u00e9 Paris-Diderot, Paris, France (C.S., F.B., M.-G.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf W.","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.v.B., G.M.D.M., H.S., U.F., M.R.H., S.J., B.G.S., H.P.M., M.A.) and Neuroradiology (J.G.), University Hospital of Bern, Bern\u00b8 Switzerland; Department of Neurology, University Hospital Zurich, Zurich, Switzerland (H.S., R.W.B.); and Department of Neurology, H\u00f4pital Lariboisi\u00e8re, APHP, Universit\u00e9 Paris-Diderot, Paris, France (C.S., F.B., M.-G.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Germaine","family":"Bousser","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.v.B., G.M.D.M., H.S., U.F., M.R.H., S.J., B.G.S., H.P.M., M.A.) and Neuroradiology (J.G.), University Hospital of Bern, Bern\u00b8 Switzerland; Department of Neurology, University Hospital Zurich, Zurich, Switzerland (H.S., R.W.B.); and Department of Neurology, H\u00f4pital Lariboisi\u00e8re, APHP, Universit\u00e9 Paris-Diderot, Paris, France (C.S., F.B., M.-G.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Arnold","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.v.B., G.M.D.M., H.S., U.F., M.R.H., S.J., B.G.S., H.P.M., M.A.) and Neuroradiology (J.G.), University Hospital of Bern, Bern\u00b8 Switzerland; Department of Neurology, University Hospital Zurich, Zurich, Switzerland (H.S., R.W.B.); and Department of Neurology, H\u00f4pital Lariboisi\u00e8re, APHP, Universit\u00e9 Paris-Diderot, Paris, France (C.S., F.B., M.-G.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1017\/S0317167100052215","article-title":"Diagnostic strategies in young patients with ischemic stroke in Canada.","volume":"27","author":"Chan MT","year":"2000","unstructured":"Chan MT, Nadareishvili ZG, Norris JW. 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