{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:10:16Z","timestamp":1785499816540,"version":"3.56.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>To date, studies on neonatal stroke have mainly focused on cortical stroke. We have focused on perforator strokes, noncortical strokes in the arterial vascular perforator area. We sought to identify risk factors and evaluate clinical presentation and neuroimaging findings for neonatal perforator stroke, which seems to be under-recognized.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>All infants admitted to our tertiary intensive care unit in \u224812 years, whose perforator stroke was diagnosed with postnatal brain imaging, were enrolled in this study. Demographic, perinatal, and postnatal data were evaluated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>Seventy-nine perforator strokes were detected in 55 patients (28 boys), with a median gestational age of 37 1\/7 weeks (range 24 1\/7 to 42 1\/7 weeks, 25 preterm). Perforator stroke was asymptomatic in most patients (58%). Initial diagnosis was predominantly made with cranial ultrasound (80%) in the first week of life (60%). Risk factors for stroke were present in all cases: maternal, fetal, and perinatal. Likely pathogenic mechanisms were prolonged birth asphyxia (16%), hypoxia or hypotension (15%), embolism (15%), infection (15%), acute blood loss (9%), and birth trauma (9%).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Previously described risk factors for developing neonatal main artery stroke are probably also associated with neonatal perforator stroke. Perforator stroke is often asymptomatic, but cranial ultrasound is a reliable diagnostic tool in diagnosing perforator stroke.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.113.001064","type":"journal-article","created":{"date-parts":[[2013,5,31]],"date-time":"2013-05-31T06:02:41Z","timestamp":1369980161000},"page":"2115-2120","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Risk Factors, Clinical Presentation, and Neuroimaging Findings of Neonatal Perforator Stroke"],"prefix":"10.1161","volume":"44","author":[{"given":"Ginette M.","family":"Ecury-Goossen","sequence":"first","affiliation":[{"name":"From the Department of Pediatrics, Division of Neonatology (G.M.E.-G., M.M.A.R., M.F.-R., P.G., J.D.) and Department of Radiology (M.L., J.D.), Erasmus MC-Sophia Children\u2019s Hospital, Rotterdam, The Netherlands; and Department of Pediatrics, Koningin Paola Children\u2019s Hospital, Antwerp, Belgium (P.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlou M.A.","family":"Raets","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Division of Neonatology (G.M.E.-G., M.M.A.R., M.F.-R., P.G., J.D.) and Department of Radiology (M.L., J.D.), Erasmus MC-Sophia Children\u2019s Hospital, Rotterdam, The Netherlands; and Department of Pediatrics, Koningin Paola Children\u2019s Hospital, Antwerp, Belgium (P.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Lequin","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Division of Neonatology (G.M.E.-G., M.M.A.R., M.F.-R., P.G., J.D.) and Department of Radiology (M.L., J.D.), Erasmus MC-Sophia Children\u2019s Hospital, Rotterdam, The Netherlands; and Department of Pediatrics, Koningin Paola Children\u2019s Hospital, Antwerp, Belgium (P.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Feijen-Roon","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Division of Neonatology (G.M.E.-G., M.M.A.R., M.F.-R., P.G., J.D.) and Department of Radiology (M.L., J.D.), Erasmus MC-Sophia Children\u2019s Hospital, Rotterdam, The Netherlands; and Department of Pediatrics, Koningin Paola Children\u2019s Hospital, Antwerp, Belgium (P.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Govaert","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Division of Neonatology (G.M.E.-G., M.M.A.R., M.F.-R., P.G., J.D.) and Department of Radiology (M.L., J.D.), Erasmus MC-Sophia Children\u2019s Hospital, Rotterdam, The Netherlands; and Department of Pediatrics, Koningin Paola Children\u2019s Hospital, Antwerp, Belgium (P.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Dudink","sequence":"additional","affiliation":[{"name":"From the Department of Pediatrics, Division of Neonatology (G.M.E.-G., M.M.A.R., M.F.-R., P.G., J.D.) and Department of Radiology (M.L., J.D.), Erasmus MC-Sophia Children\u2019s Hospital, Rotterdam, The Netherlands; and Department of Pediatrics, Koningin Paola Children\u2019s Hospital, Antwerp, Belgium (P.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00679-9"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.6.723"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.10.003"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2009.07.002"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-006-0125-2"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2009.07.006"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92296-6"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01462.x"},{"key":"e_1_3_2_10_2","first-page":"405","volume-title":"Fetal and Neonatal Neurology and Neurosurgery","author":"Levene MI","year":"1995","unstructured":"Levene MI. The asphyxiated newborn infant. In:, Levene MI, Lilford RJ, eds. Fetal and Neonatal Neurology and Neurosurgery. Edinburgh: Churchil Livingstone; 1995:405\u2013426."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.01156.x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/fetalneonatal-2010-196451"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2009.07.009"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-1490"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2009.07.001"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.7_Spec_No.840"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000129909.77753.C4"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80370-4"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.106.479311"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2010.11.002"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2009.07.004"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-006-0146-8"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.6.1400"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.10.002"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.055558"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-1148"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0336"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.113.001064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:42:45Z","timestamp":1715611365000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.113.001064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1161\/STROKEAHA.113.001064"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.113.001064","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"2013-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}