{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:14:23Z","timestamp":1777616063146,"version":"3.51.4"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Reversal of anticoagulation with protamine might predispose to a higher risk of stroke in patients with carotid stenting. We evaluated a national, multihospital patient database to examine the risk of stroke in patients with carotid stenting receiving protamine compared with those who did not.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>The Premier Perspective database was used to identify patients who were electively hospitalized for carotid stenting from 2006 through 2011. The incidence of in-hospital mortality and morbidity was compared between patients who did and did not receive protamine after propensity score adjustment via 1:1 matching to reduce selection bias.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Of 6664 patients with carotid stenting treated at 193 hospitals, 556 (8%) received protamine on the day of the procedure. After matching by propensity score, patients who received protamine had a similar likelihood of stroke or transient ischemic attack (\n              <jats:italic>P<\/jats:italic>\n              =0.77), in-hospital mortality (\n              <jats:italic>P<\/jats:italic>\n              =0.12), discharge to long-term care (\n              <jats:italic>P<\/jats:italic>\n              =0.15), and access site complications (\n              <jats:italic>P<\/jats:italic>\n              =0.90) as compared with patients who did not receive protamine.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Protamine administration is not associated with additional risk of adverse events after carotid stenting.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.113.001188","type":"journal-article","created":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T02:03:35Z","timestamp":1371002615000},"page":"2028-2030","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Protamine Does Not Increase Risk of Stroke in Patients With Elective Carotid Stenting"],"prefix":"10.1161","volume":"44","author":[{"given":"Jennifer S.","family":"McDonald","sequence":"first","affiliation":[{"name":"From the Department of Radiology (J.S.M., D.F.K., G.L., H.J.C.) and Department of Neurosurgery (D.F.K., G.L., H.J.C.), Mayo Clinic, Rochester, MN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David F.","family":"Kallmes","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (J.S.M., D.F.K., G.L., H.J.C.) and Department of Neurosurgery (D.F.K., G.L., H.J.C.), Mayo Clinic, Rochester, MN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Lanzino","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (J.S.M., D.F.K., G.L., H.J.C.) and Department of Neurosurgery (D.F.K., G.L., H.J.C.), Mayo Clinic, Rochester, MN."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry J.","family":"Cloft","sequence":"additional","affiliation":[{"name":"From the Department of Radiology (J.S.M., D.F.K., G.L., H.J.C.) and Department of Neurosurgery (D.F.K., G.L., H.J.C.), Mayo Clinic, Rochester, MN."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","unstructured":"Premier Research Services. Premier Perspective Database. Charlotte NC. 2012."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.111.000196"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circinterventions.110.950097"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(95)70140-0"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-5884(97)80082-2"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100169900222"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/hs1201.099637"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2003.09.023"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2008.01.021"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.10.078"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0741-5214(90)90046-D"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70248-6"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-010-0482-4"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.11.021"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-010-0481-5"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.113.001188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T14:48:41Z","timestamp":1738075721000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.113.001188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1161\/STROKEAHA.113.001188"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.113.001188","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"2013-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}