{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:46:55Z","timestamp":1773323215140,"version":"3.50.1"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Subarachnoid hemorrhage after intracranial aneurysm rupture remains a serious condition. We performed a case\u2013control study to evaluate the use of computed hemodynamics to detect cerebral aneurysms prone to rupture.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Four patients with incidental aneurysms that ultimately ruptured (cases) were studied after initially being included in a prospective database including their 3-dimensional imaging before rupture. Ruptures were located in different arterial segments: M1 segment of the middle cerebral artery; basilar tip; posterior inferior cerebellar artery; and anterior communicating artery. For each case, 5 controls matched by location and size were randomly selected. An empirical cumulative distribution function of aneurysm wall shear stress percentiles was evaluated for every case and used to define a critical prone-to-rupture range. Univariate logistic regression analysis was then used to assess the individual risk of rupture.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>A cumulative wall shear stress distribution characterizing a hemodynamic prone-to-rupture range for small-sized aneurysms was identified and fitted independent of the location. Sensitivity and specificity of the preliminary tests were 90% and 93%, respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>The wall shear stress cumulative probability function may be a potential predictor of small-sized aneurysm rupture.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.113.003247","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T02:39:05Z","timestamp":1384915145000},"page":"261-264","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Wall Shear Stress Distribution of Small Aneurysms Prone to Rupture"],"prefix":"10.1161","volume":"45","author":[{"given":"Vitor Mendes","family":"Pereira","sequence":"first","affiliation":[{"name":"From the Interventional Neuroradiology Unit, Service of Neuroradiology (V.M.P., O.B., P.B., A.P.N., K.-O.L., R.O.) and Service of Neurosurgery (P.B., K.S.), Faculty of Medicine, University of Geneva Hospitals, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Brina","sequence":"additional","affiliation":[{"name":"From the Interventional Neuroradiology Unit, Service of Neuroradiology (V.M.P., O.B., P.B., A.P.N., K.-O.L., R.O.) and Service of Neurosurgery (P.B., K.S.), Faculty of Medicine, University of Geneva Hospitals, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Bijlenga","sequence":"additional","affiliation":[{"name":"From the Interventional Neuroradiology Unit, Service of Neuroradiology (V.M.P., O.B., P.B., A.P.N., K.-O.L., R.O.) and Service of Neurosurgery (P.B., K.S.), Faculty of Medicine, University of Geneva Hospitals, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Bouillot","sequence":"additional","affiliation":[{"name":"From the Interventional Neuroradiology Unit, Service of Neuroradiology (V.M.P., O.B., P.B., A.P.N., K.-O.L., R.O.) and Service of Neurosurgery (P.B., K.S.), Faculty of Medicine, University of Geneva Hospitals, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula","family":"Narata","sequence":"additional","affiliation":[{"name":"From the Interventional Neuroradiology Unit, Service of Neuroradiology (V.M.P., O.B., P.B., A.P.N., K.-O.L., R.O.) and Service of Neurosurgery (P.B., K.S.), Faculty of Medicine, University of Geneva Hospitals, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Schaller","sequence":"additional","affiliation":[{"name":"From the Interventional Neuroradiology Unit, Service of Neuroradiology (V.M.P., O.B., P.B., A.P.N., K.-O.L., R.O.) and Service of Neurosurgery (P.B., K.S.), Faculty of Medicine, University of Geneva Hospitals, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Olof","family":"Lovblad","sequence":"additional","affiliation":[{"name":"From the Interventional Neuroradiology Unit, Service of Neuroradiology (V.M.P., O.B., P.B., A.P.N., K.-O.L., R.O.) and Service of Neurosurgery (P.B., K.S.), Faculty of Medicine, University of Geneva Hospitals, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafik","family":"Ouared","sequence":"additional","affiliation":[{"name":"From the Interventional Neuroradiology Unit, Service of Neuroradiology (V.M.P., O.B., P.B., A.P.N., K.-O.L., R.O.) and Service of Neurosurgery (P.B., K.S.), Faculty of Medicine, University of Geneva Hospitals, Geneva, 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