{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T01:46:39Z","timestamp":1789263999296,"version":"build-2803163510"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>Severe atherosclerosis in the aortic arch is associated with a high risk of recurrent vascular events, but the optimal antithrombotic strategy is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>This prospective randomized controlled, open-labeled trial, with blinded end point evaluation (PROBE design) tested superiority of aspirin 75 to 150 mg\/d plus clopidogrel 75 mg\/d (A+C) over warfarin therapy (international normalized ratio 2\u20133) in patients with ischemic stroke, transient ischemic attack, or peripheral embolism with plaque in the thoracic aorta &gt;4 mm and no other identified embolic source. The primary end point included cerebral infarction, myocardial infarction, peripheral embolism, vascular death, or intracranial hemorrhage. Follow-up visits occurred at 1 month and then every 4 months post randomization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>\n                      The trial was stopped after 349 patients were randomized during a period of 8 years and 3 months. After a median follow-up of 3.4 years, the primary end point occurred in 7.6% (13\/172) and 11.3% (20\/177) of patients on A+C and on warfarin, respectively (log-rank,\n                      <jats:italic>P<\/jats:italic>\n                      =0.2). The adjusted hazard ratio was 0.76 (95% confidence interval, 0.36\u20131.61;\n                      <jats:italic>P<\/jats:italic>\n                      =0.5). Major hemorrhages including intracranial hemorrhages occurred in 4 and 6 patients in the A+C and warfarin groups, respectively. Vascular deaths occurred in 0 patients in A+C arm compared with 6 (3.4%) patients in the warfarin arm (log-rank,\n                      <jats:italic>P<\/jats:italic>\n                      =0.013). Time in therapeutic range (67% of the time for international normalized ratio 2\u20133) analysis by tertiles showed no significant differences across groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Because of lack of power, this trial was inconclusive and results should be taken as hypothesis generating.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      . Unique identifier: NCT00235248.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.113.004251","type":"journal-article","created":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T16:53:24Z","timestamp":1398704004000},"page":"1248-1257","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":177,"title":["Clopidogrel Plus Aspirin Versus Warfarin in Patients With Stroke and Aortic Arch Plaques"],"prefix":"10.1161","volume":"45","author":[{"given":"Pierre","family":"Amarenco","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Stroke Centre, DHU FIRE, INSERM U 1148, Paris Diderot\u2013Sorbonne University, H\u00f4pital Bichat (P.A.), Department of Cardiology, Saint-Antoine Hospital and Medical School, Univerist\u00e9 Pierre et Marie Curie (A.A.C.), and Department of Biostatistics, Paris-Diderot\u2013Sorbonne University, H\u00f4pital Bichat (C.L.), Assistance Publique-H\u00f4pitaux de Paris, Paris, France; Department of Neurology, Royal Melbourne Hospital (S.D.) and Florey Institute of Neuroscience and Mental Health (D..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Davis","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Stroke Centre, DHU FIRE, INSERM U 1148, Paris Diderot\u2013Sorbonne University, H\u00f4pital Bichat (P.A.), Department of Cardiology, Saint-Antoine Hospital and Medical School, Univerist\u00e9 Pierre et Marie Curie (A.A.C.), and Department of Biostatistics, Paris-Diderot\u2013Sorbonne University, H\u00f4pital Bichat (C.L.), Assistance Publique-H\u00f4pitaux de Paris, Paris, France; Department of Neurology, Royal Melbourne Hospital (S.D.) and Florey Institute of Neuroscience and Mental Health (D..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth F.","family":"Jones","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Stroke Centre, DHU FIRE, INSERM U 1148, Paris Diderot\u2013Sorbonne University, H\u00f4pital Bichat (P.A.), Department of Cardiology, Saint-Antoine Hospital and Medical School, Univerist\u00e9 Pierre et Marie Curie (A.A.C.), and Department of Biostatistics, Paris-Diderot\u2013Sorbonne University, H\u00f4pital Bichat (C.L.), Assistance Publique-H\u00f4pitaux de Paris, Paris, France; Department of Neurology, Royal Melbourne Hospital (S.D.) and Florey Institute of Neuroscience and Mental Health (D..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel A.","family":"Cohen","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Stroke Centre, DHU FIRE, INSERM U 1148, Paris Diderot\u2013Sorbonne University, H\u00f4pital Bichat (P.A.), Department of Cardiology, Saint-Antoine Hospital and Medical School, Univerist\u00e9 Pierre et Marie Curie (A.A.C.), and Department of Biostatistics, Paris-Diderot\u2013Sorbonne University, H\u00f4pital Bichat (C.L.), Assistance Publique-H\u00f4pitaux de Paris, Paris, France; Department of Neurology, Royal Melbourne Hospital (S.D.) and Florey Institute of Neuroscience and Mental Health (D..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf-Dieter","family":"Heiss","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Stroke Centre, DHU FIRE, INSERM U 1148, Paris Diderot\u2013Sorbonne University, H\u00f4pital Bichat (P.A.), Department of Cardiology, Saint-Antoine Hospital and Medical School, Univerist\u00e9 Pierre et Marie Curie (A.A.C.), and Department of Biostatistics, Paris-Diderot\u2013Sorbonne University, H\u00f4pital Bichat (C.L.), Assistance Publique-H\u00f4pitaux de Paris, Paris, France; Department of Neurology, Royal Melbourne Hospital (S.D.) and Florey Institute of Neuroscience and Mental Health (D..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"Kaste","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Stroke Centre, DHU FIRE, INSERM U 1148, Paris Diderot\u2013Sorbonne University, H\u00f4pital Bichat (P.A.), Department of Cardiology, Saint-Antoine Hospital and Medical School, Univerist\u00e9 Pierre et Marie Curie (A.A.C.), and Department of Biostatistics, Paris-Diderot\u2013Sorbonne University, H\u00f4pital Bichat (C.L.), Assistance Publique-H\u00f4pitaux de Paris, Paris, France; Department of Neurology, Royal Melbourne Hospital (S.D.) and Florey Institute of Neuroscience and Mental Health (D..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Laou\u00e9nan","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Stroke Centre, DHU FIRE, INSERM U 1148, Paris Diderot\u2013Sorbonne University, H\u00f4pital Bichat (P.A.), Department of Cardiology, Saint-Antoine Hospital and Medical School, Univerist\u00e9 Pierre et Marie Curie (A.A.C.), and Department of Biostatistics, Paris-Diderot\u2013Sorbonne University, H\u00f4pital Bichat (C.L.), Assistance Publique-H\u00f4pitaux de Paris, Paris, France; Department of Neurology, Royal Melbourne Hospital (S.D.) and Florey Institute of Neuroscience and Mental Health (D..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Young","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Stroke Centre, DHU FIRE, INSERM U 1148, Paris Diderot\u2013Sorbonne University, H\u00f4pital Bichat (P.A.), Department of Cardiology, Saint-Antoine Hospital and Medical School, Univerist\u00e9 Pierre et Marie Curie (A.A.C.), and Department of Biostatistics, Paris-Diderot\u2013Sorbonne University, H\u00f4pital Bichat (C.L.), Assistance Publique-H\u00f4pitaux de Paris, Paris, France; Department of Neurology, Royal Melbourne Hospital (S.D.) and Florey Institute of Neuroscience and Mental Health (D..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Macleod","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Stroke Centre, DHU FIRE, INSERM U 1148, Paris Diderot\u2013Sorbonne University, H\u00f4pital Bichat (P.A.), Department of Cardiology, Saint-Antoine Hospital and Medical School, Univerist\u00e9 Pierre et Marie Curie (A.A.C.), and Department of Biostatistics, Paris-Diderot\u2013Sorbonne University, H\u00f4pital Bichat (C.L.), Assistance Publique-H\u00f4pitaux de Paris, Paris, France; Department of Neurology, Royal Melbourne Hospital (S.D.) and Florey Institute of Neuroscience and Mental Health (D..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey A.","family":"Donnan","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Stroke Centre, DHU FIRE, INSERM U 1148, Paris Diderot\u2013Sorbonne University, H\u00f4pital Bichat (P.A.), Department of Cardiology, Saint-Antoine Hospital and Medical School, Univerist\u00e9 Pierre et Marie Curie (A.A.C.), and Department of Biostatistics, Paris-Diderot\u2013Sorbonne University, H\u00f4pital Bichat (C.L.), Assistance Publique-H\u00f4pitaux de Paris, Paris, France; Department of Neurology, Royal Melbourne Hospital (S.D.) and Florey Institute of Neuroscience and Mental Health (D..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher F.","family":"Bladin","sequence":"additional","affiliation":[{"name":"Box Hill Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian R.","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Frayne","sequence":"additional","affiliation":[{"name":"Alfred Hospital Melbourne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme J.","family":"Hankey","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Levi","sequence":"additional","affiliation":[{"name":"John Hunter Hospital Newcastle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Read","sequence":"additional","affiliation":[{"name":"Royal Brisbane Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Ravaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turgut","family":"Tatlisumak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauri","family":"Soinne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Laine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Syv\u00e4nne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirkka","family":"Vikatmaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauri","family":"Lep\u00e4ntalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"France","family":"Mentr\u00e9","sequence":"additional","affiliation":[{"name":"France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Gosset","sequence":"additional","affiliation":[{"name":"France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid","family":"Churilov","sequence":"additional","affiliation":[{"name":"Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"De Broucker","sequence":"additional","affiliation":[{"name":"Saint-Denis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Favrole","sequence":"additional","affiliation":[{"name":"Paris, H\u00f4pital Lariboisi\u00e8re"},{"name":"Paris, H\u00f4pital Tenon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Mawet","sequence":"additional","affiliation":[{"name":"Paris, H\u00f4pital Lariboisi\u00e8re"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Mocquard","sequence":"additional","affiliation":[{"name":"Brest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Obadia","sequence":"additional","affiliation":[{"name":"Paris, Fondation Rothschild"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Godefroy","sequence":"additional","affiliation":[{"name":"Amiens"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Cr\u00e9teil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Pico","sequence":"additional","affiliation":[{"name":"Versailles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Garnier","sequence":"additional","affiliation":[{"name":"Saint-Etienne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Malbec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Pinel","sequence":"additional","affiliation":[{"name":"Rennes"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Ille","sequence":"additional","affiliation":[{"name":"Mantes la Jolie"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Vadamme","sequence":"additional","affiliation":[{"name":"La Rochelle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Macian-Montoro","sequence":"additional","affiliation":[{"name":"Limoges"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Servan","sequence":"additional","affiliation":[{"name":"Pontoise"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Viallet","sequence":"additional","affiliation":[{"name":"Aix-en-Provence"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Rosolacci","sequence":"additional","affiliation":[{"name":"Maubeuge"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Lecoz","sequence":"additional","affiliation":[{"name":"Arras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Clavelou","sequence":"additional","affiliation":[{"name":"Clermont Ferrand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Detante","sequence":"additional","affiliation":[{"name":"Grenoble"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Hee","family":"Cho","sequence":"additional","affiliation":[{"name":"Lyon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Saudeau","sequence":"additional","affiliation":[{"name":"Tours"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Michel","sequence":"additional","affiliation":[{"name":"Lausane, CHUV"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzette","family":"D\u2019Ombrogio","sequence":"additional","affiliation":[{"name":"Lausane, CHUV"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Serisier","sequence":"additional","affiliation":[{"name":"Wollongong Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon","family":"Sturm","sequence":"additional","affiliation":[{"name":"Central Coast Hospital Gosford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kimber","sequence":"additional","affiliation":[{"name":"Royal Adelaide Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romesh","family":"Marcus","sequence":"additional","affiliation":[{"name":"St Vincents Hospital, Sydney"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Southern Neurology Sydney"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Helme","sequence":"additional","affiliation":[{"name":"Western Hospital Melbourne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Blacker","sequence":"additional","affiliation":[{"name":"Sir Charles Gairdner Hospital, Perth"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Wood","sequence":"additional","affiliation":[{"name":"Nepean Hospital Penrith"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199201233260402"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-6-423"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412013312202"},{"key":"e_1_3_5_5_2","first-page":"218","article-title":"Proximal aortic atheroma. An independent risk factor for cerebral ischemia.","volume":"26","author":"Jones EF","year":"1995","unstructured":"Jones EF, Kalman JM, Calafiore P, Tonkin AM, Donnan GA. Proximal aortic atheroma. An independent risk factor for cerebral ischemia. Stroke. 1995;26:218\u2013224.","journal-title":"Stroke"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.6.1560"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00806-3"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90595-9"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.1.36"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00034-0"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.11.3838"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199605093341902"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-199702000-00013"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02870-9"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-006-0014-z"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/08037059209077502"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsb020987"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.2307\/2533535"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1651587"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805002"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60600-4"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.05.075"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061894"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06178-5"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905561"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009638"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1107039"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00146-6"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000014210.99337.d7"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420606"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011258"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043033"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)09457-3"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010746"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.19.2411"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060989"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16721-4"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2008.00204.x"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1204133"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000145053.27085.66"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215340"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.113.004251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:43:11Z","timestamp":1715596991000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.113.004251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1161\/STROKEAHA.113.004251"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.113.004251","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718338021.793493337","asserted-by":"object"}]},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"2013-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-04-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}