{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:57:27Z","timestamp":1789883847011,"version":"4.0.1"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>Studies in rodent models suggest that upregulating angiopoietin-1 (Angpt1) improves stroke outcomes. The aims of this study were to assess the association of plasma Angpt1 with stroke occurrence and outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>Plasma Angpt1 was measured in 336 patients who had experienced a recent stroke and 321 healthy controls with no stroke history. Patients with stroke (n=285) were reassessed at 3 months and plasma Angpt1 concentration on admission compared between those with severe and minor disability as assessed by the modified Rankin scale. In a separate cohort of 4032 community-acquired older men prospectively followed for a minimum of 6 years, the association of plasma Angpt1 with stroke incidence was examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>\n                      Median plasma Angpt1 was 3-fold lower in patients who had experienced a recent stroke (6.42, interquartile range, 4.26\u20139.53 compared with 17.36; interquartile range, 14.01\u201322.46 ng\/mL;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001) and remained associated with stroke after adjustment for other risk factors. Plasma Angpt1 concentrations on admission were lower in patients who had severe disability or died at 3 months (median, 5.52; interquartile range, 3.81\u20138.75 ng\/mL for modified Rankin scale 3\u20136; n=91) compared with those with minor disability (median, 7.04; interquartile range, 4.75\u20139.92 ng\/mL for modified Rankin scale 0\u20132; n=194),\n                      <jats:italic>P<\/jats:italic>\n                      =0.012, and remained negatively associated with severe disability or death after adjusting for other risk factors. Plasma Angpt1 was not predictive of stroke incidence in community-dwelling older men.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Plasma Angpt1 concentrations are low after ischemic stroke particularly in patients with poor stroke outcomes at 3 months. Interventions effective at upregulating Angpt1 could potentially improve stroke outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.113.004339","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T01:15:51Z","timestamp":1393377351000},"page":"1064-1068","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Plasma Angiopoietin-1 Is Lower After Ischemic Stroke and Associated With Major Disability But Not Stroke Incidence"],"prefix":"10.1161","volume":"45","author":[{"given":"Jonathan","family":"Golledge","sequence":"first","affiliation":[{"name":"From the Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, Australia (J.G., P.C.); Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Australia (J.G.); Faculty of Health and Medicine, School of Nursing and Midwifery (J.M.) and Faculty of Health, School of Health Sciences (C.L., J.S.), The University of Newcastle, Newcastle, Australia; The Hunter Medical Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Clancy","sequence":"additional","affiliation":[{"name":"From the Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, Australia (J.G., P.C.); Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Australia (J.G.); Faculty of Health and Medicine, School of Nursing and Midwifery (J.M.) and Faculty of Health, School of Health Sciences (C.L., J.S.), The University of Newcastle, Newcastle, Australia; The Hunter Medical Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Maguire","sequence":"additional","affiliation":[{"name":"From the Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, Australia (J.G., P.C.); Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Australia (J.G.); Faculty of Health and Medicine, School of Nursing and Midwifery (J.M.) and Faculty of Health, School of Health Sciences (C.L., J.S.), The University of Newcastle, Newcastle, Australia; The Hunter Medical Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Lincz","sequence":"additional","affiliation":[{"name":"From the Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, Australia (J.G., P.C.); Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Australia (J.G.); Faculty of Health and Medicine, School of Nursing and Midwifery (J.M.) and Faculty of Health, School of Health Sciences (C.L., J.S.), The University of Newcastle, Newcastle, Australia; The Hunter Medical Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Koblar","sequence":"additional","affiliation":[{"name":"From the Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, Australia (J.G., P.C.); Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Australia (J.G.); Faculty of Health and Medicine, School of Nursing and Midwifery (J.M.) and Faculty of Health, School of Health Sciences (C.L., J.S.), The University of Newcastle, Newcastle, Australia; The Hunter Medical Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"McEvoy","sequence":"additional","affiliation":[{"name":"From the Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, Australia (J.G., P.C.); Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Australia (J.G.); Faculty of Health and Medicine, School of Nursing and Midwifery (J.M.) and Faculty of Health, School of Health Sciences (C.L., J.S.), The University of Newcastle, Newcastle, Australia; The Hunter Medical Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Attia","sequence":"additional","affiliation":[{"name":"From the Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, Australia (J.G., P.C.); Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Australia (J.G.); Faculty of Health and Medicine, School of Nursing and Midwifery (J.M.) and Faculty of Health, School of Health Sciences (C.L., J.S.), The University of Newcastle, Newcastle, Australia; The Hunter Medical Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Levi","sequence":"additional","affiliation":[{"name":"From the Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, Australia (J.G., P.C.); Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Australia (J.G.); Faculty of Health and Medicine, School of Nursing and Midwifery (J.M.) and Faculty of Health, School of Health Sciences (C.L., J.S.), The University of Newcastle, Newcastle, Australia; The Hunter Medical Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Sturm","sequence":"additional","affiliation":[{"name":"From the Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, Australia (J.G., P.C.); Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Australia (J.G.); Faculty of Health and Medicine, School of Nursing and Midwifery (J.M.) and Faculty of Health, School of Health Sciences (C.L., J.S.), The University of Newcastle, Newcastle, Australia; The Hunter Medical Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo P.","family":"Almeida","sequence":"additional","affiliation":[{"name":"From the Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, Australia (J.G., P.C.); Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Australia (J.G.); Faculty of Health and Medicine, School of Nursing and Midwifery (J.M.) and Faculty of Health, School of Health Sciences (C.L., J.S.), The University of Newcastle, Newcastle, Australia; The Hunter Medical Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bu B.","family":"Yeap","sequence":"additional","affiliation":[{"name":"From the Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, Australia (J.G., P.C.); Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Australia (J.G.); Faculty of Health and Medicine, School of Nursing and Midwifery (J.M.) and Faculty of Health, School of Health Sciences (C.L., J.S.), The University of Newcastle, Newcastle, Australia; The Hunter Medical Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Flicker","sequence":"additional","affiliation":[{"name":"From the Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, Australia (J.G., P.C.); Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Australia (J.G.); Faculty of Health and Medicine, School of Nursing and Midwifery (J.M.) and Faculty of Health, School of Health Sciences (C.L., J.S.), The University of Newcastle, Newcastle, Australia; The Hunter Medical Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Norman","sequence":"additional","affiliation":[{"name":"From the Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, Australia (J.G., P.C.); Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Australia (J.G.); Faculty of Health and Medicine, School of Nursing and Midwifery (J.M.) and Faculty of Health, School of Health Sciences (C.L., J.S.), The University of Newcastle, Newcastle, Australia; The Hunter Medical Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme J.","family":"Hankey","sequence":"additional","affiliation":[{"name":"From the Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, Australia (J.G., P.C.); Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Australia (J.G.); Faculty of Health and Medicine, School of Nursing and Midwifery (J.M.) and Faculty of Health, School of Health Sciences (C.L., J.S.), The University of Newcastle, Newcastle, Australia; The Hunter Medical Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2007.09.004"},{"key":"e_1_3_3_3_2","first-page":"387","article-title":"Angiopoietin-1\/Tie2 receptor signaling in vascular quiescence and angiogenesis.","volume":"25","author":"Fukuhara S","year":"2010","unstructured":"Fukuhara S, Sako K, Noda K, Zhang J, Minami M, Mochizuki N. 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