{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:57:35Z","timestamp":1791172655979,"version":"4.1.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>Prior work aimed at improving our understanding of human cerebral autoregulation has explored individual physiological mechanisms of autoregulation in isolation, but none has attempted to consolidate the individual roles of these mechanisms into a comprehensive model of the overall cerebral pressure\u2013flow relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>We retrospectively analyzed this relationship before and after pharmacological blockade of \u03b1-adrenergic\u2013, muscarinic-, and calcium channel\u2013mediated mechanisms in 43 healthy volunteers to determine the relative contributions of the sympathetic, cholinergic, and myogenic controllers to cerebral autoregulation. Projection pursuit regression was used to assess the effect of pharmacological blockade on the cerebral pressure\u2013flow relationship. Subsequently, ANCOVA decomposition was used to determine the cumulative effect of these 3 mechanisms on cerebral autoregulation and whether they can fully explain it.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>\n                      Sympathetic, cholinergic, and myogenic mechanisms together accounted for 62% of the cerebral pressure\u2013flow relationship (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.05), with significant and distinct contributions from each of the 3 effectors. ANCOVA decomposition demonstrated that myogenic effectors were the largest determinant of the cerebral pressure\u2013flow relationship, but their effect was outside of the autoregulatory region where neurogenic control appeared prepotent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Our results suggest that myogenic effects occur outside the active region of autoregulation, whereas neurogenic influences are largely responsible for cerebral blood flow control within it. However, our model of cerebral autoregulation left 38% of the cerebral pressure\u2013flow relationship unexplained, suggesting that there are other physiological mechanisms that contribute to cerebral autoregulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.114.005293","type":"journal-article","created":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T02:36:34Z","timestamp":1397183794000},"page":"1771-1777","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":142,"title":["Relative Contributions of Sympathetic, Cholinergic, and Myogenic Mechanisms to Cerebral Autoregulation"],"prefix":"10.1161","volume":"45","author":[{"given":"J.W.","family":"Hamner","sequence":"first","affiliation":[{"name":"From the Cardiovascular Research Laboratory, Spaulding Rehabilitation Hospital, Boston, MA (J.W.H., C.O.T.); and Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA (C.O.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can Ozan","family":"Tan","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Research Laboratory, Spaulding Rehabilitation Hospital, Boston, MA (J.W.H., C.O.T.); and Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA (C.O.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.180"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1997.86.3.0425"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000334498"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.112.659888"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.7.1341"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.109.557132"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.245100"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.259747"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1961.200.4.711"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00794.2006"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1961.200.6.1157"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.41.3.324"},{"key":"e_1_3_3_14_2","first-page":"16","volume-title":"Encyclopedia of Medical Decision Making","author":"Olejnik S","year":"2009","unstructured":"Olejnik S, Keselman H. Analysis of covariance (ANCOVA). In: , Kattan M Encyclopedia of Medical Decision Making. Thousand Oaks, CA: SAGE Publications Inc; 2009:16\u201322."},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.7.1672"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.281.3.R716"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.066969"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00783.2012"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.5.1830"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199907000-00010"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(05)80065-1"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.274.1.H233"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1109\/T-C.1974.224051"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1981.10477729"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511611377"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2004-5-10-r80"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-201X.1998.tb10702.x"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1115\/1.1645525"},{"key":"e_1_3_3_29_2","volume-title":"Regulation of Vascular Tone in Skeletal Muscle. Skeletal Muscle Circulation","author":"Korthius RJ","year":"2011","unstructured":"Korthius RJRegulation of Vascular Tone in Skeletal Muscle. Skeletal Muscle Circulation. Rafael, CA: Morgan & Claypool Life Sciences; 2011."},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000057973.99140.5a"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00373.2003"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0990555"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.114.005293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:11:27Z","timestamp":1715595087000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.114.005293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1161\/STROKEAHA.114.005293"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.114.005293","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"2014-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}