{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T09:22:31Z","timestamp":1781342551022,"version":"3.54.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>We aimed at comparing the long-term benefit\u2013risk balance of carotid stenting versus endarterectomy for symptomatic carotid stenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>Long-term follow-up study of patients included in Endarterectomy Versus Angioplasty in Patients With Symptomatic Severe Carotid Stenosis (EVA-3S), a randomized, controlled trial of carotid stenting versus endarterectomy in 527 patients with recently symptomatic severe carotid stenosis, conducted in 30 centers in France. The main end point was a composite of any ipsilateral stroke after randomization or any procedural stroke or death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>\n                      During a median follow-up of 7.1 years (interquartile range, 5.1\u20138.8 years; maximum 12.4 years), the primary end point occurred in 30 patients in the stenting group compared with 18 patients in the endarterectomy group. Cumulative probabilities of this outcome were 11.0% (95% confidence interval, 7.9\u201315.2) versus 6.3% (4.0\u20139.8) in the endarterectomy group at the 5-year follow-up (hazard ratio, 1.85; 1.00\u20133.40;\n                      <jats:italic>P<\/jats:italic>\n                      =0.04) and 11.5% (8.2\u201315.9) versus 7.6% (4.9\u201311.8; hazard ratio, 1.70; 0.95\u20133.06;\n                      <jats:italic>P<\/jats:italic>\n                      =0.07) at the 10-year follow-up. No difference was observed between treatment groups in the rates of ipsilateral stroke beyond the procedural period, severe carotid restenosis (\u226570%) or occlusion, death, myocardial infarction, and revascularization procedures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>The long-term benefit\u2013risk balance of carotid stenting versus endarterectomy for symptomatic carotid stenosis favored endarterectomy, a difference driven by a lower risk of procedural stroke after endarterectomy. Both techniques were associated with low and similar long-term risks of recurrent ipsilateral stroke beyond the procedural period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      . Unique identifier: NCT00190398.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.114.005671","type":"journal-article","created":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T03:26:08Z","timestamp":1406863568000},"page":"2750-2756","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":120,"title":["Long-Term Follow-Up Study of Endarterectomy Versus Angioplasty in Patients With Symptomatic Severe Carotid Stenosis Trial"],"prefix":"10.1161","volume":"45","author":[{"given":"Jean-Louis","family":"Mas","sequence":"first","affiliation":[{"name":"From the H\u00f4pital Sainte-Anne, Universit\u00e9 Paris-Descartes, INSERM U894, DHU Neurovasc-Paris Sorbonne, Paris, France (J.-L.M., D.C.); H\u00f4pital Gui de Chauliac, Universit\u00e9 Montpellier 1, Montpellier, France (C.A.); H\u00f4pital Rangueil (A.V., V.L.) and H\u00f4pital Purpan (J.-F.A.), Universit\u00e9 Paul Sabatier, Toulouse, France; H\u00f4pital de la Timone, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France (P.P., L.M.); H\u00f4pital Nord, Universit\u00e9 Jean Monnet, Saint-Etienne, France (P.G.); H\u00f4pital C\u00f4te de Nacre, Universit\u00e9 de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Arquizan","sequence":"additional","affiliation":[{"name":"From the H\u00f4pital Sainte-Anne, Universit\u00e9 Paris-Descartes, INSERM U894, DHU Neurovasc-Paris Sorbonne, Paris, France (J.-L.M., D.C.); H\u00f4pital Gui de Chauliac, Universit\u00e9 Montpellier 1, Montpellier, France (C.A.); H\u00f4pital Rangueil (A.V., V.L.) and H\u00f4pital Purpan (J.-F.A.), Universit\u00e9 Paul Sabatier, Toulouse, France; H\u00f4pital de la Timone, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France (P.P., L.M.); H\u00f4pital Nord, Universit\u00e9 Jean Monnet, Saint-Etienne, France (P.G.); H\u00f4pital C\u00f4te de Nacre, Universit\u00e9 de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Calvet","sequence":"additional","affiliation":[{"name":"From the H\u00f4pital Sainte-Anne, Universit\u00e9 Paris-Descartes, INSERM U894, DHU Neurovasc-Paris Sorbonne, Paris, France (J.-L.M., D.C.); H\u00f4pital Gui de Chauliac, Universit\u00e9 Montpellier 1, Montpellier, France (C.A.); H\u00f4pital Rangueil (A.V., V.L.) and H\u00f4pital Purpan (J.-F.A.), Universit\u00e9 Paul Sabatier, Toulouse, France; H\u00f4pital de la Timone, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France (P.P., L.M.); H\u00f4pital Nord, Universit\u00e9 Jean Monnet, Saint-Etienne, France (P.G.); H\u00f4pital C\u00f4te de Nacre, Universit\u00e9 de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Viguier","sequence":"additional","affiliation":[{"name":"From the H\u00f4pital Sainte-Anne, Universit\u00e9 Paris-Descartes, INSERM U894, DHU Neurovasc-Paris Sorbonne, Paris, France (J.-L.M., D.C.); H\u00f4pital Gui de Chauliac, Universit\u00e9 Montpellier 1, Montpellier, France (C.A.); H\u00f4pital Rangueil (A.V., V.L.) and H\u00f4pital Purpan (J.-F.A.), Universit\u00e9 Paul Sabatier, Toulouse, France; H\u00f4pital de la Timone, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France (P.P., L.M.); H\u00f4pital Nord, Universit\u00e9 Jean Monnet, Saint-Etienne, France (P.G.); H\u00f4pital C\u00f4te de Nacre, Universit\u00e9 de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Albucher","sequence":"additional","affiliation":[{"name":"From the H\u00f4pital Sainte-Anne, Universit\u00e9 Paris-Descartes, INSERM U894, DHU Neurovasc-Paris Sorbonne, Paris, France (J.-L.M., D.C.); H\u00f4pital Gui de Chauliac, Universit\u00e9 Montpellier 1, Montpellier, France (C.A.); H\u00f4pital Rangueil (A.V., V.L.) and H\u00f4pital Purpan (J.-F.A.), Universit\u00e9 Paul Sabatier, Toulouse, France; H\u00f4pital de la Timone, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France (P.P., L.M.); H\u00f4pital Nord, Universit\u00e9 Jean Monnet, Saint-Etienne, France (P.G.); H\u00f4pital C\u00f4te de Nacre, Universit\u00e9 de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Piquet","sequence":"additional","affiliation":[{"name":"From the H\u00f4pital Sainte-Anne, Universit\u00e9 Paris-Descartes, INSERM U894, DHU Neurovasc-Paris Sorbonne, Paris, France (J.-L.M., D.C.); H\u00f4pital Gui de Chauliac, Universit\u00e9 Montpellier 1, Montpellier, France (C.A.); H\u00f4pital Rangueil (A.V., V.L.) and H\u00f4pital Purpan (J.-F.A.), Universit\u00e9 Paul Sabatier, Toulouse, France; H\u00f4pital de la Timone, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France (P.P., L.M.); H\u00f4pital Nord, Universit\u00e9 Jean Monnet, Saint-Etienne, France (P.G.); H\u00f4pital C\u00f4te de Nacre, Universit\u00e9 de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Garnier","sequence":"additional","affiliation":[{"name":"From the H\u00f4pital Sainte-Anne, Universit\u00e9 Paris-Descartes, INSERM U894, DHU Neurovasc-Paris Sorbonne, Paris, France (J.-L.M., D.C.); H\u00f4pital Gui de Chauliac, Universit\u00e9 Montpellier 1, Montpellier, France (C.A.); H\u00f4pital Rangueil (A.V., V.L.) and H\u00f4pital Purpan (J.-F.A.), Universit\u00e9 Paul Sabatier, Toulouse, France; H\u00f4pital de la Timone, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France (P.P., L.M.); H\u00f4pital Nord, Universit\u00e9 Jean Monnet, Saint-Etienne, France (P.G.); H\u00f4pital C\u00f4te de Nacre, Universit\u00e9 de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto","family":"Viader","sequence":"additional","affiliation":[{"name":"From the H\u00f4pital Sainte-Anne, Universit\u00e9 Paris-Descartes, INSERM U894, DHU Neurovasc-Paris Sorbonne, Paris, France (J.-L.M., D.C.); H\u00f4pital Gui de Chauliac, Universit\u00e9 Montpellier 1, Montpellier, France (C.A.); H\u00f4pital Rangueil (A.V., V.L.) and H\u00f4pital Purpan (J.-F.A.), Universit\u00e9 Paul Sabatier, Toulouse, France; H\u00f4pital de la Timone, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France (P.P., L.M.); H\u00f4pital Nord, Universit\u00e9 Jean Monnet, Saint-Etienne, France (P.G.); H\u00f4pital C\u00f4te de Nacre, Universit\u00e9 de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Giroud","sequence":"additional","affiliation":[{"name":"From the H\u00f4pital Sainte-Anne, Universit\u00e9 Paris-Descartes, INSERM U894, DHU Neurovasc-Paris Sorbonne, Paris, France (J.-L.M., D.C.); H\u00f4pital Gui de Chauliac, Universit\u00e9 Montpellier 1, Montpellier, France (C.A.); H\u00f4pital Rangueil (A.V., V.L.) and H\u00f4pital Purpan (J.-F.A.), Universit\u00e9 Paul Sabatier, Toulouse, France; H\u00f4pital de la Timone, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France (P.P., L.M.); H\u00f4pital Nord, Universit\u00e9 Jean Monnet, Saint-Etienne, France (P.G.); H\u00f4pital C\u00f4te de Nacre, Universit\u00e9 de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Hosseini","sequence":"additional","affiliation":[{"name":"From the H\u00f4pital Sainte-Anne, Universit\u00e9 Paris-Descartes, INSERM U894, DHU Neurovasc-Paris Sorbonne, Paris, France (J.-L.M., D.C.); H\u00f4pital Gui de Chauliac, Universit\u00e9 Montpellier 1, Montpellier, France (C.A.); H\u00f4pital Rangueil (A.V., V.L.) and H\u00f4pital Purpan (J.-F.A.), Universit\u00e9 Paul Sabatier, Toulouse, France; H\u00f4pital de la Timone, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France (P.P., L.M.); H\u00f4pital Nord, Universit\u00e9 Jean Monnet, Saint-Etienne, France (P.G.); H\u00f4pital C\u00f4te de Nacre, Universit\u00e9 de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Hinzelin","sequence":"additional","affiliation":[{"name":"From the H\u00f4pital Sainte-Anne, Universit\u00e9 Paris-Descartes, INSERM U894, DHU Neurovasc-Paris Sorbonne, Paris, France (J.-L.M., D.C.); H\u00f4pital Gui de Chauliac, Universit\u00e9 Montpellier 1, Montpellier, France (C.A.); H\u00f4pital Rangueil (A.V., V.L.) and H\u00f4pital Purpan (J.-F.A.), Universit\u00e9 Paul Sabatier, Toulouse, France; H\u00f4pital de la Timone, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France (P.P., L.M.); H\u00f4pital Nord, Universit\u00e9 Jean Monnet, Saint-Etienne, France (P.G.); H\u00f4pital C\u00f4te de Nacre, Universit\u00e9 de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Favrole","sequence":"additional","affiliation":[{"name":"From the H\u00f4pital Sainte-Anne, Universit\u00e9 Paris-Descartes, INSERM U894, DHU Neurovasc-Paris Sorbonne, Paris, France (J.-L.M., D.C.); H\u00f4pital Gui de Chauliac, Universit\u00e9 Montpellier 1, Montpellier, France (C.A.); H\u00f4pital Rangueil (A.V., V.L.) and H\u00f4pital Purpan (J.-F.A.), Universit\u00e9 Paul Sabatier, Toulouse, France; H\u00f4pital de la Timone, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France (P.P., L.M.); H\u00f4pital Nord, Universit\u00e9 Jean Monnet, Saint-Etienne, France (P.G.); H\u00f4pital C\u00f4te de Nacre, Universit\u00e9 de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde","family":"H\u00e9non","sequence":"additional","affiliation":[{"name":"From the H\u00f4pital Sainte-Anne, Universit\u00e9 Paris-Descartes, INSERM U894, DHU Neurovasc-Paris Sorbonne, Paris, France (J.-L.M., D.C.); H\u00f4pital Gui de Chauliac, Universit\u00e9 Montpellier 1, Montpellier, France (C.A.); H\u00f4pital Rangueil (A.V., V.L.) and H\u00f4pital Purpan (J.-F.A.), Universit\u00e9 Paul Sabatier, Toulouse, France; H\u00f4pital de la Timone, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France (P.P., L.M.); H\u00f4pital Nord, Universit\u00e9 Jean Monnet, Saint-Etienne, France (P.G.); H\u00f4pital C\u00f4te de Nacre, Universit\u00e9 de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Neau","sequence":"additional","affiliation":[{"name":"From the H\u00f4pital Sainte-Anne, Universit\u00e9 Paris-Descartes, INSERM U894, DHU Neurovasc-Paris Sorbonne, Paris, France (J.-L.M., D.C.); H\u00f4pital Gui de Chauliac, Universit\u00e9 Montpellier 1, Montpellier, France (C.A.); H\u00f4pital Rangueil (A.V., V.L.) and H\u00f4pital Purpan (J.-F.A.), Universit\u00e9 Paul Sabatier, Toulouse, France; H\u00f4pital de la Timone, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France (P.P., L.M.); H\u00f4pital Nord, Universit\u00e9 Jean Monnet, Saint-Etienne, France (P.G.); H\u00f4pital C\u00f4te de Nacre, Universit\u00e9 de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Ducrocq","sequence":"additional","affiliation":[{"name":"From the H\u00f4pital Sainte-Anne, Universit\u00e9 Paris-Descartes, INSERM U894, DHU Neurovasc-Paris Sorbonne, Paris, France (J.-L.M., D.C.); H\u00f4pital Gui de Chauliac, Universit\u00e9 Montpellier 1, Montpellier, France (C.A.); H\u00f4pital Rangueil (A.V., V.L.) and H\u00f4pital Purpan (J.-F.A.), Universit\u00e9 Paul Sabatier, Toulouse, France; H\u00f4pital de la Timone, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France (P.P., L.M.); H\u00f4pital Nord, Universit\u00e9 Jean Monnet, Saint-Etienne, France (P.G.); H\u00f4pital C\u00f4te de Nacre, Universit\u00e9 de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Padovani","sequence":"additional","affiliation":[{"name":"From the H\u00f4pital Sainte-Anne, Universit\u00e9 Paris-Descartes, INSERM U894, DHU Neurovasc-Paris Sorbonne, Paris, France (J.-L.M., D.C.); H\u00f4pital Gui de Chauliac, Universit\u00e9 Montpellier 1, Montpellier, France (C.A.); H\u00f4pital Rangueil (A.V., V.L.) and H\u00f4pital Purpan (J.-F.A.), Universit\u00e9 Paul Sabatier, Toulouse, France; H\u00f4pital de la Timone, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France (P.P., L.M.); H\u00f4pital Nord, Universit\u00e9 Jean Monnet, Saint-Etienne, France (P.G.); H\u00f4pital C\u00f4te de Nacre, Universit\u00e9 de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loic","family":"Milandre","sequence":"additional","affiliation":[{"name":"From the H\u00f4pital Sainte-Anne, Universit\u00e9 Paris-Descartes, INSERM U894, DHU Neurovasc-Paris Sorbonne, Paris, France (J.-L.M., D.C.); H\u00f4pital Gui de Chauliac, Universit\u00e9 Montpellier 1, Montpellier, France (C.A.); H\u00f4pital Rangueil (A.V., V.L.) and H\u00f4pital Purpan (J.-F.A.), Universit\u00e9 Paul Sabatier, Toulouse, France; H\u00f4pital de la Timone, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France (P.P., L.M.); H\u00f4pital Nord, Universit\u00e9 Jean Monnet, Saint-Etienne, France (P.G.); H\u00f4pital C\u00f4te de Nacre, Universit\u00e9 de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Rouanet","sequence":"additional","affiliation":[{"name":"From the H\u00f4pital Sainte-Anne, Universit\u00e9 Paris-Descartes, INSERM U894, DHU Neurovasc-Paris Sorbonne, Paris, France (J.-L.M., D.C.); H\u00f4pital Gui de Chauliac, Universit\u00e9 Montpellier 1, Montpellier, France (C.A.); H\u00f4pital Rangueil (A.V., V.L.) and H\u00f4pital Purpan (J.-F.A.), Universit\u00e9 Paul Sabatier, Toulouse, France; H\u00f4pital de la Timone, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France (P.P., L.M.); H\u00f4pital Nord, Universit\u00e9 Jean Monnet, Saint-Etienne, France (P.G.); H\u00f4pital C\u00f4te de Nacre, Universit\u00e9 de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Wolff","sequence":"additional","affiliation":[{"name":"From the H\u00f4pital Sainte-Anne, Universit\u00e9 Paris-Descartes, INSERM U894, DHU Neurovasc-Paris Sorbonne, Paris, France (J.-L.M., D.C.); H\u00f4pital Gui de Chauliac, Universit\u00e9 Montpellier 1, Montpellier, France (C.A.); H\u00f4pital Rangueil (A.V., V.L.) and H\u00f4pital Purpan (J.-F.A.), Universit\u00e9 Paul Sabatier, Toulouse, France; H\u00f4pital de la Timone, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France (P.P., L.M.); 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