{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T03:44:50Z","timestamp":1779248690602,"version":"3.51.4"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Visit-to-visit variability in systolic blood pressure (SBP) is associated with an increased risk of stroke and was reduced in randomized trials by calcium channel blockers and diuretics but not by renin\u2013angiotensin system inhibitors. However, time of day effects could not be determined. Day-to-day variability on home BP readings predicts stroke risk and potentially offers a practical method of monitoring response to variability-directed treatment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>SBP mean, maximum, and variability (coefficient of variation=SD\/mean) were determined in 500 consecutive transient ischemic attack or minor stroke patients on 1-month home BP monitoring (3 BPs, 3\u00d7 daily). Hypertension was treated to a standard protocol. Differences in SBP variability from 3 to 10 days before to 8 to 15 days after starting or increasing calcium channel blockers\/diuretics versus renin\u2013angiotensin system inhibitors versus both were compared by general linear models, adjusted for risk factors and baseline BP.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Among 288 eligible interventions, variability in SBP was reduced after increased treatment with calcium channel blockers\/diuretics versus both versus renin\u2013angiotensin system inhibitors (\u22124.0 versus 6.9 versus 7.8%;\n              <jats:italic>P<\/jats:italic>\n              =0.015), primarily because of effects on maximum SBP (\u22124.6 versus \u22121.0 versus \u22121.0%;\n              <jats:italic>P<\/jats:italic>\n              =0.001), with no differences in effect on mean SBP. Class differences were greatest for early-morning SBP variability (3.6 versus 17.0 versus 38.3;\n              <jats:italic>P<\/jats:italic>\n              =0.002) and maximum (\u22124.8 versus \u22122.0 versus \u22120.7;\n              <jats:italic>P<\/jats:italic>\n              =0.001), with no effect on midmorning (\n              <jats:italic>P<\/jats:italic>\n              =0.29), evening (\n              <jats:italic>P<\/jats:italic>\n              =0.65), or diurnal variability (\n              <jats:italic>P<\/jats:italic>\n              =0.92).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>After transient ischemic attack or minor stroke, calcium channel blockers and diuretics reduced variability and maximum home SBP, primarily because of effects on morning readings. Home BP readings enable monitoring of response to SBP variability-directed treatment in patients with recent cerebrovascular events.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.114.005982","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T08:09:29Z","timestamp":1408694969000},"page":"2967-2973","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["Response of Day-to-Day Home Blood Pressure Variability by Antihypertensive Drug Class After Transient Ischemic Attack or Nondisabling Stroke"],"prefix":"10.1161","volume":"45","author":[{"given":"Alastair J.S.","family":"Webb","sequence":"first","affiliation":[{"name":"From the Stroke Prevention Research Unit, Oxford University, Oxford, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Wilson","sequence":"additional","affiliation":[{"name":"From the Stroke Prevention Research Unit, Oxford University, Oxford, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Lovett","sequence":"additional","affiliation":[{"name":"From the Stroke Prevention Research Unit, Oxford University, Oxford, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Paul","sequence":"additional","affiliation":[{"name":"From the Stroke Prevention Research Unit, Oxford University, Oxford, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urs","family":"Fischer","sequence":"additional","affiliation":[{"name":"From the Stroke Prevention Research Unit, Oxford University, Oxford, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Rothwell","sequence":"additional","affiliation":[{"name":"From the Stroke Prevention Research Unit, Oxford University, Oxford, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60309-1"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60308-X"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70066-1"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60235-8"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822b007a"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.110.589531"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.110.611566"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.9.1671"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.107.104620"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.111.178657"},{"key":"e_1_3_4_12_2","first-page":"124","article-title":"Clinical and physiological validity of maximum blood pressure on multi-day home measurement versus single-day ambulatory monitoring: frequency versus duration?","volume":"35","author":"Webb AJS","year":"2013","unstructured":"Webb AJS, Wilson M, Paul NL, Fischer U, Rothwell PM. Clinical and physiological validity of maximum blood pressure on multi-day home measurement versus single-day ambulatory monitoring: frequency versus duration? Cer Dis. 2013;35(suppl 3):124.","journal-title":"Cer Dis"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200312001-00019"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16405-2"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61448-2"},{"key":"e_1_3_4_16_2","first-page":"72","article-title":"Identification of missed hypertension and hypertensive arteriopathy with home versus ambulatory blood pressure measurement in patients with TIA or minor stroke.","volume":"35","author":"Webb AJS","year":"2013","unstructured":"Webb AJS, Wilson M, Paul NL, Fischer U, Lovett NG, Li L, et al.. Identification of missed hypertension and hypertensive arteriopathy with home versus ambulatory blood pressure measurement in patients with TIA or minor stroke. Cer Dis. 2013;35(suppl 3):72.","journal-title":"Cer Dis"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.113.003321"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0b013e32835ebc58"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.109.140798"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200312000-00014"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.114.005982","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:11:07Z","timestamp":1715609467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.114.005982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1161\/STROKEAHA.114.005982"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.114.005982","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"2014-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-07-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}