{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T12:19:34Z","timestamp":1791721174249,"version":"4.3.4"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Aspirin early after intravenous thrombolysis in acute ischemic stroke increases the risk of symptomatic intracranial hemorrhage (SICH), without influencing functional outcome at 3 months. The effect of aspirin on early neurological deterioration (END) was explored as a post hoc analysis of the randomized Antiplatelet Therapy in Combination With Recombinant t-PA Thrombolysis in Ischemic Stroke (ARTIS) trial.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>\n              END, defined as a \u22654 points National Institutes of Health Stroke Scale worsening \u226424 hours after intravenous thrombolysis, was categorized into SICH (END\n              <jats:sub>SICH<\/jats:sub>\n              ) and cerebral ischemia (END\n              <jats:sub>CI<\/jats:sub>\n              ). Multinomial logistic regression was used to assess the effect of aspirin on END.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Of the 640 patients, 31 patients (4.8%) experienced END (14 END\n              <jats:sub>SICH<\/jats:sub>\n              , 17 END\n              <jats:sub>CI<\/jats:sub>\n              ). Aspirin increased the risk of END\n              <jats:sub>SICH<\/jats:sub>\n              (odds ratio, 3.73; 95% confidence interval, 1.03\u201313.49) but not of END\n              <jats:sub>CI<\/jats:sub>\n              (odds ratio, 1.14; 95% confidence interval, 0.44\u20133.00). After adjustment for other explanatory variables, the association between aspirin and END\n              <jats:sub>SICH<\/jats:sub>\n              remained significant.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>In this trial, there is no evidence of an early antithrombotic effect from the addition of aspirin to intravenous thrombolysis in acute ischemic stroke.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.114.006268","type":"journal-article","created":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T04:18:16Z","timestamp":1408508296000},"page":"3080-3082","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":55,"title":["Early Deterioration After Thrombolysis Plus Aspirin in Acute Stroke"],"prefix":"10.1161","volume":"45","author":[{"given":"Sanne M.","family":"Zinkstok","sequence":"first","affiliation":[{"name":"From the Departments of Neurology (S.M.Z., Y.B.R.), Radiology (L.F.B., C.B.M., H.A.M.), Biomedical Engineering and Physics (H.A.M.), and the Clinical Research Unit (R.J.d.H.), Academic Medical Center University, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludo F.","family":"Beenen","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (S.M.Z., Y.B.R.), Radiology (L.F.B., C.B.M., H.A.M.), Biomedical Engineering and Physics (H.A.M.), and the Clinical Research Unit (R.J.d.H.), Academic Medical Center University, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles B.","family":"Majoie","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (S.M.Z., Y.B.R.), Radiology (L.F.B., C.B.M., H.A.M.), Biomedical Engineering and Physics (H.A.M.), and the Clinical Research Unit (R.J.d.H.), Academic Medical Center University, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk A.","family":"Marquering","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (S.M.Z., Y.B.R.), Radiology (L.F.B., C.B.M., H.A.M.), Biomedical Engineering and Physics (H.A.M.), and the Clinical Research Unit (R.J.d.H.), Academic Medical Center University, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob J.","family":"de Haan","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (S.M.Z., Y.B.R.), Radiology (L.F.B., C.B.M., H.A.M.), Biomedical Engineering and Physics (H.A.M.), and the Clinical Research Unit (R.J.d.H.), Academic Medical Center University, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvo B.","family":"Roos","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (S.M.Z., Y.B.R.), Radiology (L.F.B., C.B.M., H.A.M.), Biomedical Engineering and Physics (H.A.M.), and the Clinical Research Unit (R.J.d.H.), Academic Medical Center University, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60949-0"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.109.569459"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.597435"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000251800.01964.f6"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.3.661"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02237-6"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.511162"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)60007-4"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.5.noc70077"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70101-7"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000319029"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000333064"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.114.006268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:11:38Z","timestamp":1715609498000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.114.006268"}},"subtitle":["A Post Hoc Analysis of the Antiplatelet Therapy in Combination With Recombinant t-PA Thrombolysis in Ischemic Stroke Trial"],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1161\/STROKEAHA.114.006268"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.114.006268","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"2014-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-07-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication 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