{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T18:36:07Z","timestamp":1769106967911,"version":"3.49.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>The widespread use of ambulatory cardiac monitoring has not only increased the detection of high-risk arrhythmias like persistent and paroxysmal atrial fibrillation (AF), but also made it possible to identify other aberrations such as short-lasting (&lt;30 seconds) irregular runs of supraventricular tachycardia. Ischemic stroke phenotype might be helpful in understanding whether these nonsustained episodes play a similar role in stroke pathophysiology like their persistent and paroxysmal counterparts.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>In a consecutive series of patients with ischemic stroke, we retrospectively determined clinical and imaging features associated with nonsustained AF (n=126), defined as &lt;30-second-lasting supraventricular tachyarrhythmias with irregular RR interval on 24-hour Holter monitoring, and compared them to patients with persistent\/paroxysmal AF (n=239) and no AF (n=246).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>Patients with persistent\/paroxysmal AF significantly differed from patients with nonsustained AF by a higher prevalence of female sex (odds ratio [95% confidence interval], 1.8 [1.1\u20132.9]), coronary artery disease (1.9 [1.1\u20133.0]), and embolic imaging features (2.7 [1.1\u20136.5]), and lower frequency of smoking (0.4 [0.2\u20130.8]) and hyperlipidemia (0.5 [0.3\u20130.8]). In contrast, patients with no AF were younger (0.5 [0.4\u20130.6] per decade) and more likely to be male (1.7 [1.0\u20132.8]) in comparison with nonsustained AF population. The prevalence of nonsustained AF was similar among cryptogenic and noncryptogenic stroke patients (32% versus 29%). Voxel-wise comparison of lesion probability maps revealed no significant difference between cryptogenic stroke patients with and without nonsustained AF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Clinical features of patients with nonsustained AF exhibited an intermediary phenotype in between patients with persistent\/paroxysmal AF and no AF. Furthermore, imaging features did not entirely resemble patterns observed in patients with longer durations of AF.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.114.006396","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T03:33:54Z","timestamp":1422588834000},"page":"634-640","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Ischemic Stroke Phenotype in Patients With Nonsustained Atrial Fibrillation"],"prefix":"10.1161","volume":"46","author":[{"given":"Ethem M.","family":"Arsava","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Faculty of Medicine (E.M.A., D.F.B., M.A.T.), Department of Cardiology, Faculty of Medicine (E.A.), and Department of Radiology, Faculty of Medicine (K.K.O.), Hacettepe University, Ankara, Turkey; and National Magnetic Resonance Research Center, Bilkent University, Ankara, Turkey (A.C.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demet F.","family":"Bas","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Faculty of Medicine (E.M.A., D.F.B., M.A.T.), Department of Cardiology, Faculty of Medicine (E.A.), and Department of Radiology, Faculty of Medicine (K.K.O.), Hacettepe University, Ankara, Turkey; and National Magnetic Resonance Research Center, Bilkent University, Ankara, Turkey (A.C.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enver","family":"Atalar","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Faculty of Medicine (E.M.A., D.F.B., M.A.T.), Department of Cardiology, Faculty of Medicine (E.A.), and Department of Radiology, Faculty of Medicine (K.K.O.), Hacettepe University, Ankara, Turkey; and National Magnetic Resonance Research Center, Bilkent University, Ankara, Turkey (A.C.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arzu C.","family":"Has","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Faculty of Medicine (E.M.A., D.F.B., M.A.T.), Department of Cardiology, Faculty of Medicine (E.A.), and Department of Radiology, Faculty of Medicine (K.K.O.), Hacettepe University, Ankara, Turkey; and National Magnetic Resonance Research Center, Bilkent University, Ankara, Turkey (A.C.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kader K.","family":"Oguz","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Faculty of Medicine (E.M.A., D.F.B., M.A.T.), Department of Cardiology, Faculty of Medicine (E.A.), and Department of Radiology, Faculty of Medicine (K.K.O.), Hacettepe University, Ankara, Turkey; and National Magnetic Resonance Research Center, Bilkent University, Ankara, Turkey (A.C.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet A.","family":"Topcuoglu","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Faculty of Medicine (E.M.A., D.F.B., M.A.T.), Department of Cardiology, Faculty of Medicine (E.A.), and Department of Radiology, Faculty of Medicine (K.K.O.), Hacettepe University, Ankara, Turkey; and National Magnetic Resonance Research Center, Bilkent University, Ankara, Turkey (A.C.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000166053.83476.4a"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00489-1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.07.076"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311376"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000131269.69502.d9"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.106.478685"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1313600"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105575"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828f1828"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000325059.86313.31"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eum120"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003788"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000057981.70380.45"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2008.01320.x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.07.044"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.609297"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.490896"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1132"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001884"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.029801"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.665844"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.570382"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.05.013"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq278"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-008-0728-8"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.22.2864"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00585-3"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.004800"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12268"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.114.006396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:17:09Z","timestamp":1715609829000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.114.006396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1161\/STROKEAHA.114.006396"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.114.006396","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"2014-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}