{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T20:20:14Z","timestamp":1769113214117,"version":"3.49.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Paroxysmal atrial fibrillation (PAF) is often difficult to detect in patients with acute ischemic stroke. We aimed to assess the predictive value of a prolonged QT interval corrected for heart rate (QTc) in PAF detection after acute ischemic stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>We enrolled 972 patients with acute ischemic stroke consecutively extracted from our observational stroke registry system. Exclusion criteria were as follows: (1) AF on the initial 12-lead ECG (n=171); (2) previously diagnosed PAF (n=47); and (3) the use of a cardiac pacemaker (n=10). Of the 972 patients, 744 (mean age, 67.6 years; men, 62.6%) were eligible for analysis. The clinical characteristics and 12-lead ECG findings of the patients with and without PAF were compared, and multiple logistic regression analysis was performed to identify predictors of poststroke PAF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              The poststroke cardiac work-up yielded 69 (9.3%) de novo PAF cases among the 744 patients. The QTc interval was significantly longer in patients with PAF than in those without PAF (436 versus 417 ms;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Each 10-ms increase in the QTc interval was associated with an increased risk of PAF after multivariate adjustments (odds ratio, 1.41; 95% confidence interval, 1.24\u20131.61;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The optimal threshold value of QTc interval calculated by a receiver-operating characteristic curve was 438 ms, and the area under the curve was 0.73 in this data set.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>The QTc interval prolongation is potentially a strong and useful predictor for poststroke PAF.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.114.006612","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T03:54:46Z","timestamp":1416542086000},"page":"71-76","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Prolonged QTc Interval Predicts Poststroke Paroxysmal Atrial Fibrillation"],"prefix":"10.1161","volume":"46","author":[{"given":"Takao","family":"Hoshino","sequence":"first","affiliation":[{"name":"From the Department of Neurology (T.H., T.N., K.M., S.T., S.M., K.I., S.U., K.K.), Department of Cardiology (T.S.), and Medical Research Institute (S.S.), Tokyo Women\u2019s Medical University, Tokyo, Japan; Clinical Research Center for Medicine, International University of Health and Welfare, Tokyo, Japan (S.U.); and Center for Brain and Cerebral Vessels, Sanno Hospital Sanno Medical Center, Tokyo, Japan (S.U.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiko","family":"Nagao","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (T.H., T.N., K.M., S.T., S.M., K.I., S.U., K.K.), Department of Cardiology (T.S.), and Medical Research Institute (S.S.), Tokyo Women\u2019s Medical University, Tokyo, Japan; Clinical Research Center for Medicine, International University of Health and Welfare, Tokyo, Japan (S.U.); and Center for Brain and Cerebral Vessels, Sanno Hospital Sanno Medical Center, Tokyo, Japan (S.U.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Shiga","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (T.H., T.N., K.M., S.T., S.M., K.I., S.U., K.K.), Department of Cardiology (T.S.), and Medical Research Institute (S.S.), Tokyo Women\u2019s Medical University, Tokyo, Japan; Clinical Research Center for Medicine, International University of Health and Welfare, Tokyo, Japan (S.U.); and Center for Brain and Cerebral Vessels, Sanno Hospital Sanno Medical Center, Tokyo, Japan (S.U.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Maruyama","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (T.H., T.N., K.M., S.T., S.M., K.I., S.U., K.K.), Department of Cardiology (T.S.), and Medical Research Institute (S.S.), Tokyo Women\u2019s Medical University, Tokyo, Japan; Clinical Research Center for Medicine, International University of Health and Welfare, Tokyo, Japan (S.U.); and Center for Brain and Cerebral Vessels, Sanno Hospital Sanno Medical Center, Tokyo, Japan (S.U.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sono","family":"Toi","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (T.H., T.N., K.M., S.T., S.M., K.I., S.U., K.K.), Department of Cardiology (T.S.), and Medical Research Institute (S.S.), Tokyo Women\u2019s Medical University, Tokyo, Japan; Clinical Research Center for Medicine, International University of Health and Welfare, Tokyo, Japan (S.U.); and Center for Brain and Cerebral Vessels, Sanno Hospital Sanno Medical Center, Tokyo, Japan (S.U.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Mizuno","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (T.H., T.N., K.M., S.T., S.M., K.I., S.U., K.K.), Department of Cardiology (T.S.), and Medical Research Institute (S.S.), Tokyo Women\u2019s Medical University, Tokyo, Japan; Clinical Research Center for Medicine, International University of Health and Welfare, Tokyo, Japan (S.U.); and Center for Brain and Cerebral Vessels, Sanno Hospital Sanno Medical Center, Tokyo, Japan (S.U.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Ishizuka","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (T.H., T.N., K.M., S.T., S.M., K.I., S.U., K.K.), Department of Cardiology (T.S.), and Medical Research Institute (S.S.), Tokyo Women\u2019s Medical University, Tokyo, Japan; Clinical Research Center for Medicine, International University of Health and Welfare, Tokyo, Japan (S.U.); and Center for Brain and Cerebral Vessels, Sanno Hospital Sanno Medical Center, Tokyo, Japan (S.U.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Shimizu","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (T.H., T.N., K.M., S.T., S.M., K.I., S.U., K.K.), Department of Cardiology (T.S.), and Medical Research Institute (S.S.), Tokyo Women\u2019s Medical University, Tokyo, Japan; Clinical Research Center for Medicine, International University of Health and Welfare, Tokyo, Japan (S.U.); and Center for Brain and Cerebral Vessels, Sanno Hospital Sanno Medical Center, Tokyo, Japan (S.U.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (T.H., T.N., K.M., S.T., S.M., K.I., S.U., K.K.), Department of Cardiology (T.S.), and Medical Research Institute (S.S.), Tokyo Women\u2019s Medical University, Tokyo, Japan; Clinical Research Center for Medicine, International University of Health and Welfare, Tokyo, Japan (S.U.); and Center for Brain and Cerebral Vessels, Sanno Hospital Sanno Medical Center, Tokyo, Japan 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