{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:38:44Z","timestamp":1769161124986,"version":"3.49.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>In patients with acute middle cerebral artery (MCA) stroke, therapeutic decisions are influenced by the location of the occlusion. This study aimed to analyze clinical outcomes in patients with acute ischemic MCA stroke treated with systemic intravenous thrombolysis (IVT) using recombinant tissue plasminogen activator, according to the location of the occlusion.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Of 621 patients screened, 136 with acute stroke and MCA occlusion confirmed by CT angiography were retrospectively included in this study. The distance from the carotid T to the thrombus (DT) on coronal maximum intensity projection images and the thrombus length were measured. The correlation between DT and the modified Rankin Scale score at 90 days was analyzed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              DT was an independent predictor of clinical outcome in stroke patients treated with IVT. A long DT was significantly correlated with a good clinical outcome (modified Rankin Scale score at 90 days \u22642). A poor clinical outcome was exponentially more likely than a good outcome when the DT was &lt;16 mm (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The thrombus length was not correlated with the modified Rankin Scale score at 90 days. A long thrombus (&gt;8 mm) occurred significantly more often in the proximal MCA than the distal MCA (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>DT is an independent predictor of clinical outcome in patients with acute MCA occlusion treated with IVT. In acute stroke with MCA occlusion confirmed by CT angiography and DT &lt;16 mm, the likelihood of a good clinical outcome after treatment with IVT was exponentially &lt;50%. This might warrant the evaluation of other therapy forms than IVT in patients with proximal MCA occlusion.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.114.008454","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T03:29:14Z","timestamp":1423020554000},"page":"692-696","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":42,"title":["Distance to Thrombus in Acute Middle Cerebral Artery Occlusion"],"prefix":"10.1161","volume":"46","author":[{"given":"Benjamin","family":"Friedrich","sequence":"first","affiliation":[{"name":"From the Department of Interventional and Diagnostic Radiology (B.F., M.G., M.R.), Department of Neuroradiology (S.S., K.-T.H., D.L.), and Department of Neurology (C.H.), University Hospital Leipzig, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Gawlitza","sequence":"additional","affiliation":[{"name":"From the Department of Interventional and Diagnostic Radiology (B.F., M.G., M.R.), Department of Neuroradiology (S.S., K.-T.H., D.L.), and Department of Neurology (C.H.), University Hospital Leipzig, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Schob","sequence":"additional","affiliation":[{"name":"From the Department of Interventional and Diagnostic Radiology (B.F., M.G., M.R.), Department of Neuroradiology (S.S., K.-T.H., D.L.), and Department of Neurology (C.H.), University Hospital Leipzig, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Hobohm","sequence":"additional","affiliation":[{"name":"From the Department of Interventional and Diagnostic Radiology (B.F., M.G., M.R.), Department of Neuroradiology (S.S., K.-T.H., D.L.), and Department of Neurology (C.H.), University Hospital Leipzig, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Raviolo","sequence":"additional","affiliation":[{"name":"From the Department of Interventional and Diagnostic Radiology (B.F., M.G., M.R.), Department of Neuroradiology (S.S., K.-T.H., D.L.), and Department of Neurology (C.H.), University Hospital Leipzig, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Titus","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"From the Department of Interventional and Diagnostic Radiology (B.F., M.G., M.R.), Department of Neuroradiology (S.S., K.-T.H., D.L.), and Department of Neurology (C.H.), University Hospital Leipzig, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Lobsien","sequence":"additional","affiliation":[{"name":"From the Department of Interventional and Diagnostic Radiology (B.F., M.G., M.R.), Department of Neuroradiology (S.S., K.-T.H., D.L.), and Department of Neurology (C.H.), University Hospital Leipzig, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.621904"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2014.03.001"},{"key":"e_1_3_2_4_2","unstructured":"Berkhemer OA Fransen PSS Beumer D van den Berg LA Lingsma HF Yoo AJ et al.. A randomized trial of intraarterial treatment for acute ischemic stroke. [published online ahead of print December 17 2014]. N Engl J Med. 2014. http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa1411587. Accessed December 26 2014."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214300"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1212793"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60149-4"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.2.366"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005731"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.609693"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","unstructured":"Behme D Kowoll A Weber W Mpotsaris A. M1 is not M1 in ischemic stroke: the disability-free survival after mechanical thrombectomy differs significantly between proximal and distal occlusions of the middle cerebral artery M1 segment. [published online ahead of print June 24 2014]. J Neurointerventional Surg. 2014. http:\/\/jnis.bmj.com\/content\/early\/2014\/06\/24\/neurintsurg-2014-011212.long. Accessed November 25 2014.","DOI":"10.1136\/neurintsurg-2014-011212"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001972"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1981.54.2.0151"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-006-0632-9"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.580662"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12230"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.114.008454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:18:19Z","timestamp":1715609899000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.114.008454"}},"subtitle":["A Predictor of Outcome After Intravenous Thrombolysis for Acute Ischemic Stroke"],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1161\/STROKEAHA.114.008454"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.114.008454","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"2014-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}