{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T13:05:53Z","timestamp":1777295153387,"version":"3.51.4"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Elevated soluble CD40 ligand (sCD40L) was shown to be related to cardiovascular events, but the role of sCD40L in predicting recurrent stroke remains unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Baseline sCD40L levels were measured in 3044 consecutive patients with acute minor stroke and transient ischemic attack, who had previously been enrolled in the Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events (CHANCE) trial. Cox proportional-hazards model was used to assess the association of sCD40L with recurrent stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Patients in the top tertile of sCD40L levels had increased risk of recurrent stroke comparing with those in the bottom tertile, after adjusted for conventional confounding factors (hazard ratio, 1.49; 95% confidence interval, 1.11\u20132.00;\n              <jats:italic>P<\/jats:italic>\n              =0.008). The patients with elevated levels of both sCD40L and high-sensitive C-reactive protein also had increased risk of recurrent stroke (hazard ratio, 1.81; 95% confidence interval, 1.23\u20132.68;\n              <jats:italic>P<\/jats:italic>\n              =0.003).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Elevated sCD40L levels independently predict recurrent stroke in patients with minor stroke and transient ischemic attack.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT00979589.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.115.008685","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T13:41:01Z","timestamp":1432734061000},"page":"1990-1992","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["Soluble CD40L Is a Useful Marker to Predict Future Strokes in Patients With Minor Stroke and Transient Ischemic Attack"],"prefix":"10.1161","volume":"46","author":[{"given":"Jiejie","family":"Li","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.L., Yilong Wang, J.L., A.W., X.Z., L.L., C.W., Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (Yongjun Wang); and Illinois Neurological, Institute..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yilong","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.L., Yilong Wang, J.L., A.W., X.Z., L.L., C.W., Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (Yongjun Wang); and Illinois Neurological, Institute..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinxi","family":"Lin","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.L., Yilong Wang, J.L., A.W., X.Z., L.L., C.W., Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (Yongjun Wang); and Illinois Neurological, Institute..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.L., Yilong Wang, J.L., A.W., X.Z., L.L., C.W., Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (Yongjun Wang); and Illinois Neurological, Institute..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anxin","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.L., Yilong Wang, J.L., A.W., X.Z., L.L., C.W., Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (Yongjun Wang); and Illinois Neurological, Institute..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingquan","family":"Zhao","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.L., Yilong Wang, J.L., A.W., X.Z., L.L., C.W., Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (Yongjun Wang); and Illinois Neurological, Institute..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Liu","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.L., Yilong Wang, J.L., A.W., X.Z., L.L., C.W., Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (Yongjun Wang); and Illinois Neurological, Institute..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxue","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.L., Yilong Wang, J.L., A.W., X.Z., L.L., C.W., Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (Yongjun Wang); and Illinois Neurological, Institute..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.L., Yilong Wang, J.L., A.W., X.Z., L.L., C.W., Yongjun Wang); China National Clinical Research Center for Neurological Diseases, Beijing, China (Yongjun Wang); Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (Yongjun Wang); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (Yongjun Wang); and Illinois Neurological, Institute..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/hh2401.101272"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000154878.58398.14"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022600"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.10.44"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215340"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.152777"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000260090.90508.3e"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2006.05.003"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005592"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.289"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.115.008685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:09:37Z","timestamp":1715609377000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.115.008685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1161\/STROKEAHA.115.008685"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.115.008685","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"2014-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}