{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T10:10:54Z","timestamp":1781777454839,"version":"3.54.5"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>\n                      Previous studies reported that Tat-NR2B9c, a peptide disrupting the\n                      <jats:italic>N<\/jats:italic>\n                      -methyl-\n                      <jats:sc>d<\/jats:sc>\n                      -aspartate receptor\u2013postsynaptic density protein-95 interaction, reduced ischemic damage in the acute phase after stroke. However, its effect in the subacute phase is unknown. The aim of this study is to determine whether disrupting the\n                      <jats:italic>N<\/jats:italic>\n                      -methyl-\n                      <jats:sc>d<\/jats:sc>\n                      -aspartate receptor\u2013postsynaptic density protein-95 interaction in the subacute phase promotes recovery after stroke.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>\n                      Studies were performed on Sprague-Dawley rats or nNOS\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice, and experimental ischemic stroke was induced by middle cerebral artery occlusion. Animals were treated with drugs starting at day 4 after ischemia. Sensorimotor functions and spatial learning and memory ability were assessed after drug treatment. Then, rats were euthanized for morphological observation and biochemical tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>\n                      Disrupting the\n                      <jats:italic>N<\/jats:italic>\n                      -methyl-\n                      <jats:sc>d<\/jats:sc>\n                      -aspartate receptor\u2013postsynaptic density protein-95 interaction with Tat-HA-NR2B9c significantly ameliorated the ischemia-induced impairments of spatial memory and sensorimotor functions in rats during subacute stage but did not improve stroke outcome in nNOS\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice. Consistent with the functional recovery, Tat-HA-NR2B9c substantially increased neurogenesis in the dentate gyrus and dendritic spine density of mature neurons in the motor cortex of rats, meanwhile, reversed the ischemia-induced formation of\n                      <jats:italic>S<\/jats:italic>\n                      -nitrosylation-cyclin-dependent kinase 5 and increased cyclin-dependent kinase 5 activity in ipsilateral hippocampus. However, directly blocking\n                      <jats:italic>N<\/jats:italic>\n                      -methyl-\n                      <jats:sc>d<\/jats:sc>\n                      -aspartate receptors with MK-801 or Ro 25-6981 did not show the beneficial effects above.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>\n                      Dissociating\n                      <jats:italic>N<\/jats:italic>\n                      -methyl-\n                      <jats:sc>d<\/jats:sc>\n                      -aspartate receptor\u2013postsynaptic density protein-95 coupling by Tat-HA-NR2B9c in the subacute phase after stroke promotes functional recovery, probably because of that it increases neurogenesis and dendritic spine density of mature neurons via regulating cyclin-dependent kinase 5 in the ischemic brain.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.115.008886","type":"journal-article","created":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T00:46:54Z","timestamp":1428454014000},"page":"1352-1358","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Delayed Administration of Tat-HA-NR2B9c Promotes Recovery After Stroke in Rats"],"prefix":"10.1161","volume":"46","author":[{"given":"Hai-Hui","family":"Zhou","sequence":"first","affiliation":[{"name":"From the Department of Pharmacology, School of Pharmacy (H.-H.Z., Y.T., X.-Y.Z., C.-X.L., L.-Y.G., H.-Y.W., L.C., D.-Y.Z.), Institution of Stem Cells and Neuroregeneration (C.-X.L., H.-Y.W., D.-Y.Z.), Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Tang","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology, School of Pharmacy (H.-H.Z., Y.T., X.-Y.Z., C.-X.L., L.-Y.G., H.-Y.W., L.C., D.-Y.Z.), Institution of Stem Cells and Neuroregeneration (C.-X.L., H.-Y.W., D.-Y.Z.), Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology, School of Pharmacy (H.-H.Z., Y.T., X.-Y.Z., C.-X.L., L.-Y.G., H.-Y.W., L.C., D.-Y.Z.), Institution of Stem Cells and Neuroregeneration (C.-X.L., H.-Y.W., D.-Y.Z.), Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Xia","family":"Luo","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology, School of Pharmacy (H.-H.Z., Y.T., X.-Y.Z., C.-X.L., L.-Y.G., H.-Y.W., L.C., D.-Y.Z.), Institution of Stem Cells and Neuroregeneration (C.-X.L., H.-Y.W., D.-Y.Z.), Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Yan","family":"Gao","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology, School of Pharmacy (H.-H.Z., Y.T., X.-Y.Z., C.-X.L., L.-Y.G., H.-Y.W., L.C., D.-Y.Z.), Institution of Stem Cells and Neuroregeneration (C.-X.L., H.-Y.W., D.-Y.Z.), Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Yin","family":"Wu","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology, School of Pharmacy (H.-H.Z., Y.T., X.-Y.Z., C.-X.L., L.-Y.G., H.-Y.W., L.C., D.-Y.Z.), Institution of Stem Cells and Neuroregeneration (C.-X.L., H.-Y.W., D.-Y.Z.), Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chang","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology, School of Pharmacy (H.-H.Z., Y.T., X.-Y.Z., C.-X.L., L.-Y.G., H.-Y.W., L.C., D.-Y.Z.), Institution of Stem Cells and Neuroregeneration (C.-X.L., H.-Y.W., D.-Y.Z.), Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Ya","family":"Zhu","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology, School of Pharmacy (H.-H.Z., Y.T., X.-Y.Z., C.-X.L., L.-Y.G., H.-Y.W., L.C., D.-Y.Z.), Institution of Stem Cells and Neuroregeneration (C.-X.L., H.-Y.W., D.-Y.Z.), Nanjing Medical University, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","updated-by":[{"DOI":"10.1161\/str.0000000000000224","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000},"record-id":"22846"},{"DOI":"10.1161\/str.0000000000000224","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000}}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/STROKEAHA.115.008886","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:07:01Z","timestamp":1715594821000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.115.008886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1161\/STROKEAHA.115.008886"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.115.008886","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725426957.793506840","asserted-by":"object"}]},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"2015-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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