{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:56:17Z","timestamp":1792403777879,"version":"4.4.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Acquired apraxia of speech (AOS) is a motor speech disorder caused by brain damage. AOS often co-occurs with aphasia, a language disorder in which patients may also demonstrate speech production errors. The overlap of speech production deficits in both disorders has raised questions on whether AOS emerges from a unique pattern of brain damage or as a subelement of the aphasic syndrome. The purpose of this study was to determine whether speech production errors in AOS and aphasia are associated with distinctive patterns of brain injury.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Forty-three patients with history of a single left-hemisphere stroke underwent comprehensive speech and language testing. The AOS Rating Scale was used to rate speech errors specific to AOS versus speech errors that can also be associated with both AOS and aphasia. Localized brain damage was identified using structural magnetic resonance imaging, and voxel-based lesion-impairment mapping was used to evaluate the relationship between speech errors specific to AOS, those that can occur in AOS or aphasia, and brain damage.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>The pattern of brain damage associated with AOS was most strongly associated with damage to cortical motor regions, with additional involvement of somatosensory areas. Speech production deficits that could be attributed to AOS or aphasia were associated with damage to the temporal lobe and the inferior precentral frontal regions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>AOS likely occurs in conjunction with aphasia because of the proximity of the brain areas supporting speech and language, but the neurobiological substrate for each disorder differs.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.115.009211","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T03:26:34Z","timestamp":1429845994000},"page":"1561-1566","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":109,"title":["Patterns of Poststroke Brain Damage That Predict Speech Production Errors in Apraxia of Speech and Aphasia Dissociate"],"prefix":"10.1161","volume":"46","author":[{"given":"Alexandra","family":"Basilakos","sequence":"first","affiliation":[{"name":"From the Aphasia Lab, Department of Communication Sciences and Disorders (A.B., J.F.), Department of Psychology (C.R.), University of South Carolina, Columbia; Department of Neurosciences, Medical University of South Carolina, Charleston (L.B.); and Department of Communication Sciences &amp; Disorders, University of New Hampshire, Durham (D.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Rorden","sequence":"additional","affiliation":[{"name":"From the Aphasia Lab, Department of Communication Sciences and Disorders (A.B., J.F.), Department of Psychology (C.R.), University of South Carolina, Columbia; Department of Neurosciences, Medical University of South Carolina, Charleston (L.B.); and Department of Communication Sciences &amp; Disorders, University of New Hampshire, Durham (D.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Bonilha","sequence":"additional","affiliation":[{"name":"From the Aphasia Lab, Department of Communication Sciences and Disorders (A.B., J.F.), Department of Psychology (C.R.), University of South Carolina, Columbia; Department of Neurosciences, Medical University of South Carolina, Charleston (L.B.); and Department of Communication Sciences &amp; Disorders, University of New Hampshire, Durham (D.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Moser","sequence":"additional","affiliation":[{"name":"From the Aphasia Lab, Department of Communication Sciences and Disorders (A.B., J.F.), Department of Psychology (C.R.), University of South Carolina, Columbia; Department of Neurosciences, Medical University of South Carolina, Charleston (L.B.); and Department of Communication Sciences &amp; Disorders, University of New Hampshire, Durham (D.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Fridriksson","sequence":"additional","affiliation":[{"name":"From the Aphasia Lab, Department of Communication Sciences and Disorders (A.B., J.F.), Department of Psychology (C.R.), University of South Carolina, Columbia; Department of Neurosciences, Medical University of South Carolina, Charleston (L.B.); and Department of Communication Sciences &amp; Disorders, University of New Hampshire, Durham (D.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","volume-title":"Motor Speech Disorders: Substrates, Differential Diagnosis, And Management","author":"Duffy JR","year":"2013","unstructured":"Duffy JRMotor Speech Disorders: Substrates, Differential Diagnosis, And Management. 3rd ed. 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