{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:52:12Z","timestamp":1790808732645,"version":"4.1.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Prevalence of cerebral microbleeds (CMB) in white and Asian populations range from 4% to 15%. However, there is no information from indigenous Latin American people. We aimed to assess prevalence and cerebrovascular correlates of CMB in stroke-free older adults living in rural Ecuador.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Of 311 Atahualpa residents aged \u226560 years identified during a door-to-door survey, 258 (83%) underwent brain magnetic resonance imaging. Twenty-one were further excluded for a diagnosis of overt stroke. Using multivariate logistic regression models, adjusted for demographics and cardiovascular risk factors, we evaluated whether CMB were independently associated with silent strokes, white matter hyperintensities, and global cortical atrophy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Twenty-six (11%) of 237 participants had CMB, which were single in 54% of cases. CMB were deep in 11 patients, cortical in 9, and located both deep and cortical in 6. In univariate analyses, CMB were associated with age, systolic blood pressure, moderate-to-severe white matter hyperintensities, silent lacunar infarcts, and cortical atrophy. Mean (\u00b1SD) values for systolic blood pressure were 155\u00b127 mm Hg in patients who had CMB versus 142\u00b126 mm Hg in those who did not (\n              <jats:italic>P<\/jats:italic>\n              =0.017). In the adjusted models, moderate-to-severe white matter hyperintensities (\n              <jats:italic>P<\/jats:italic>\n              =0.009), silent lacunar infarcts (\n              <jats:italic>P<\/jats:italic>\n              =0.003), and global cortical atrophy (\n              <jats:italic>P<\/jats:italic>\n              =0.04) were independently associated with CMB.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Prevalence of CMB in stroke-free older adults living in Atahualpa is comparable with those reported from other ethnic groups. There is a strong relationship between CMB and increased age, high systolic blood pressure, silent markers of cerebral small vessel disease, and cortical atrophy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.115.009594","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T02:57:04Z","timestamp":1432868224000},"page":"1984-1986","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Population-Based Study of Cerebral Microbleeds in Stroke-Free Older Adults Living in Rural Ecuador"],"prefix":"10.1161","volume":"46","author":[{"given":"Victor J.","family":"Del Brutto","sequence":"first","affiliation":[{"name":"From the Internal Medicine Department, Louis A. Weiss Memorial Hospital, Chicago, IL (V.J.D.B.); Community Center, The Atahualpa Project, Atahualpa, Ecuador (M.Z.); Gastroenterology Department, University of Vanderbilt, Nashville, TN (R.M.M.); and School of Medicine, Universidad Esp\u00edritu Santo\u2014Ecuador, Guayaquil, Ecuador (O.H.D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Zambrano","sequence":"additional","affiliation":[{"name":"From the Internal Medicine Department, Louis A. Weiss Memorial Hospital, Chicago, IL (V.J.D.B.); Community Center, The Atahualpa Project, Atahualpa, Ecuador (M.Z.); Gastroenterology Department, University of Vanderbilt, Nashville, TN (R.M.M.); and School of Medicine, Universidad Esp\u00edritu Santo\u2014Ecuador, Guayaquil, Ecuador (O.H.D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robertino M.","family":"Mera","sequence":"additional","affiliation":[{"name":"From the Internal Medicine Department, Louis A. Weiss Memorial Hospital, Chicago, IL (V.J.D.B.); Community Center, The Atahualpa Project, Atahualpa, Ecuador (M.Z.); Gastroenterology Department, University of Vanderbilt, Nashville, TN (R.M.M.); and School of Medicine, Universidad Esp\u00edritu Santo\u2014Ecuador, Guayaquil, Ecuador (O.H.D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar H.","family":"Del Brutto","sequence":"additional","affiliation":[{"name":"From the Internal Medicine Department, Louis A. Weiss Memorial Hospital, Chicago, IL (V.J.D.B.); Community Center, The Atahualpa Project, Atahualpa, Ecuador (M.Z.); Gastroenterology Department, University of Vanderbilt, Nashville, TN (R.M.M.); and School of Medicine, Universidad Esp\u00edritu Santo\u2014Ecuador, Guayaquil, Ecuador (O.H.D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000331466"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00205"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000131809.35202.1b"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.121913"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.595181"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12270"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12030"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12417"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70124-8"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c34a7d"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000081050"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000117270"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000365847"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.115.009594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:09:36Z","timestamp":1715609376000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.115.009594"}},"subtitle":["The Atahualpa Project"],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":13,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1161\/STROKEAHA.115.009594"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.115.009594","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"2015-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}