{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:19Z","timestamp":1787018119546,"version":"build-2736575974"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>Small cerebellar infarct cavities have been recently found on magnetic resonance imaging (MRI) to preferentially involve the cerebellar cortex, but epidemiological studies are lacking. We aimed to determine the prevalence and risk factor profiles of cerebellar cortical infarct cavities (\u22641.5 cm) as well as their association with MRI markers of cerebrovascular disease and functioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>We analyzed the 1.5 Tesla MRI of 636 patients (mean age, 62\u00b19 years; 81% men) from the Second Manifestations of Arterial Disease-Memory, Depression and Aging (SMART-Medea) study. Logistic regression analyses were performed to estimate the associations of age, sex, vascular risk factors, MRI markers of cerebrovascular disease, and functioning with cerebellar cortical cavities, adjusted for age and sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>Cerebellar cortical infarct cavities occurred on MRI in 10% of patients and were significantly associated with age, intima-media thickness (odds ratio [OR], 2.0; 95% confidence interval [CI], 1.1\u20133.7), high levels of homocysteinemia (OR, 1.8; 95% CI, 1.0\u20133.3), cortical infarcts (OR, 2.9; 95% CI, 1.6\u20135.4), gray matter lacunes of presumed vascular origin (OR, 3.0; 95% CI, 1.6\u20135.8), brain stem infarcts (OR, 5.1; 95% CI, 1.9\u201313.6), and decreased brain parenchymal fraction (OR, 0.84; 95% CI, 0.74\u20130.94), but not with white matter hyperintensities (OR, 1.2; 95% CI, 0.8\u20131.8) or white matter lacunes of presumed vascular origin (OR, 1.1; 95% CI, 0.5\u20132.5). They were also associated with worse physical functioning (OR 0.96; 95% CI, 0.94 to 0.99) but not with mental functioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Cerebellar cortical infarct cavities are far more common than previously assumed based on symptomatic case series and are associated with markers of atherothromboembolic cerebrovascular disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.115.010093","type":"journal-article","created":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T04:48:21Z","timestamp":1442551701000},"page":"3154-3160","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Cerebellar Cortical Infarct Cavities"],"prefix":"10.1161","volume":"46","author":[{"given":"Laurens J.L.","family":"De Cocker","sequence":"first","affiliation":[{"name":"From the Department of Radiology(L.J.L.D.C., P.R.L., J.H.) and Julius Center for Health Sciences and Primary Care (R.P.K., Y.v.d.G., M.I.G.), University Medical Center Utrecht, Utrecht, The Netherlands; and Department of Neurology, Sint Franciscus Gasthuis, Rotterdam, The Netherlands (R.P.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul P.","family":"Kloppenborg","sequence":"additional","affiliation":[{"name":"From the Department of Radiology(L.J.L.D.C., P.R.L., J.H.) and Julius Center for Health Sciences and Primary Care (R.P.K., Y.v.d.G., M.I.G.), University Medical Center Utrecht, Utrecht, The Netherlands; and Department of Neurology, Sint Franciscus Gasthuis, Rotterdam, The Netherlands (R.P.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"van der Graaf","sequence":"additional","affiliation":[{"name":"From the Department of Radiology(L.J.L.D.C., P.R.L., J.H.) and Julius Center for Health Sciences and Primary Care (R.P.K., Y.v.d.G., M.I.G.), University Medical Center Utrecht, Utrecht, The Netherlands; and Department of Neurology, Sint Franciscus Gasthuis, Rotterdam, The Netherlands (R.P.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Luijten","sequence":"additional","affiliation":[{"name":"From the Department of Radiology(L.J.L.D.C., P.R.L., J.H.) and Julius Center for Health Sciences and Primary Care (R.P.K., Y.v.d.G., M.I.G.), University Medical Center Utrecht, Utrecht, The Netherlands; and Department of Neurology, Sint Franciscus Gasthuis, Rotterdam, The Netherlands (R.P.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Hendrikse","sequence":"additional","affiliation":[{"name":"From the Department of Radiology(L.J.L.D.C., P.R.L., J.H.) and Julius Center for Health Sciences and Primary Care (R.P.K., Y.v.d.G., M.I.G.), University Medical Center Utrecht, Utrecht, The Netherlands; and Department of Neurology, Sint Franciscus Gasthuis, Rotterdam, The Netherlands (R.P.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam I.","family":"Geerlings","sequence":"additional","affiliation":[{"name":"From the Department of Radiology(L.J.L.D.C., P.R.L., J.H.) and Julius Center for Health Sciences and Primary Care (R.P.K., Y.v.d.G., M.I.G.), University Medical Center Utrecht, Utrecht, The Netherlands; and Department of Neurology, Sint Franciscus Gasthuis, Rotterdam, The Netherlands (R.P.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Members of the SMART study group are","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Algra","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary 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