{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T19:03:18Z","timestamp":1772910198593,"version":"3.50.1"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>A substantial part of ischemic strokes is attributed to atrial fibrillation (AF). We hypothesized that patients with ischemic stroke without prior diagnosed AF were at higher risk of having a subsequent diagnosis of AF, and this was associated with multiple risk factors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>This French longitudinal cohort study was based on the national database covering hospital care from 2008 to 2012 for the entire population.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Of 65 807 patients with ischemic stroke in 2009, 48 992 did not have AF at baseline. A total of 4828 of these patients were diagnosed as having AF during a follow-up of 15\u00b115 months (incidence rate 7.9 per 100 person-years). By comparison, the yearly rate of new-onset AF for the 826 416 patients with a cardiac hospitalization was 5.9%. CHADS\n              <jats:sub>2<\/jats:sub>\n              (congestive heart failure, hypertension, age \u226575 years, diabetes mellitus, stroke\/transient ischemic attack) and CHA\n              <jats:sub>2<\/jats:sub>\n              DS\n              <jats:sub>2<\/jats:sub>\n              -VASc (congestive heart failure, hypertension, age \u226575 years, diabetes mellitus, stroke\/transient ischemic attack [doubled], vascular disease, age 65\u201375 years, and sex category [female]) scores were both associated with the risk of new-onset AF during follow-up (CHADS\n              <jats:sub>2<\/jats:sub>\n              : hazard ratio [HR] 1.70, 95% confidence interval [CI] 1.66\u20131.75; CHA\n              <jats:sub>2<\/jats:sub>\n              DS\n              <jats:sub>2<\/jats:sub>\n              -VASc: HR 1.45, 95% CI 1.42\u20131.48). The c statistics were 0.700 (95% CI 0.696\u20130.706) for CHADS\n              <jats:sub>2<\/jats:sub>\n              and 0.706 (95% CI 0.702\u20130.710) with CHA\n              <jats:sub>2<\/jats:sub>\n              DS\n              <jats:sub>2<\/jats:sub>\n              -VASc (\n              <jats:italic>P<\/jats:italic>\n              =0.003 for comparison of the 2 scores). Independent predictors of subsequent diagnosis of AF were age 65 to 74 years (HR 2.29, 95% CI 2.06\u20132.54), age \u226575 years (HR 3.31, 95% CI 3.02\u20133.64), hypertension (HR 1.22, 95% CI 1.13\u20131.32), heart failure (HR 2.56, 95% CI 2.41\u20132.72), and vascular disease (HR 1.10, 95% CI 1.04\u20131.17).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>\n              Ischemic stroke was associated with a substantially increased risk of incident AF, particularly among individuals with higher CHADS\n              <jats:sub>2<\/jats:sub>\n              or CHA\n              <jats:sub>2<\/jats:sub>\n              DS\n              <jats:sub>2<\/jats:sub>\n              -VASc scores. These risk scores seem to be simple tools for identifying patients at higher risk of incident AF after ischemic stroke.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.115.010270","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T03:14:30Z","timestamp":1438917270000},"page":"2432-2437","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":86,"title":["Patients With Ischemic Stroke and Incident Atrial Fibrillation"],"prefix":"10.1161","volume":"46","author":[{"given":"Laurent","family":"Fauchier","sequence":"first","affiliation":[{"name":"From the Service de Cardiologie, P\u00f4le C\u0153ur Thorax Vasculaire, Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine, Universit\u00e9 Fran\u00e7ois Rabelais, Tours, France (L.F., N.C.); Medtronic France, Boulogne-Billancourt, France (C.P., C.C.); Medtronic Europe, Tolochenaz, Switzerland (E.N.); and University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom (G.Y.H.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Clementy","sequence":"additional","affiliation":[{"name":"From the Service de Cardiologie, P\u00f4le C\u0153ur Thorax Vasculaire, Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine, Universit\u00e9 Fran\u00e7ois Rabelais, Tours, France (L.F., N.C.); Medtronic France, Boulogne-Billancourt, France (C.P., C.C.); Medtronic Europe, Tolochenaz, Switzerland (E.N.); and University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom (G.Y.H.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christele","family":"Pelade","sequence":"additional","affiliation":[{"name":"From the Service de Cardiologie, P\u00f4le C\u0153ur Thorax Vasculaire, Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine, Universit\u00e9 Fran\u00e7ois Rabelais, Tours, France (L.F., N.C.); Medtronic France, Boulogne-Billancourt, France (C.P., C.C.); Medtronic Europe, Tolochenaz, Switzerland (E.N.); and University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom (G.Y.H.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecile","family":"Collignon","sequence":"additional","affiliation":[{"name":"From the Service de Cardiologie, P\u00f4le C\u0153ur Thorax Vasculaire, Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine, Universit\u00e9 Fran\u00e7ois Rabelais, Tours, France (L.F., N.C.); Medtronic France, Boulogne-Billancourt, France (C.P., C.C.); Medtronic Europe, Tolochenaz, Switzerland (E.N.); and University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom (G.Y.H.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Nicolle","sequence":"additional","affiliation":[{"name":"From the Service de Cardiologie, P\u00f4le C\u0153ur Thorax Vasculaire, Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine, Universit\u00e9 Fran\u00e7ois Rabelais, Tours, France (L.F., N.C.); Medtronic France, Boulogne-Billancourt, France (C.P., C.C.); Medtronic Europe, Tolochenaz, Switzerland (E.N.); and University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom (G.Y.H.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory Y.H.","family":"Lip","sequence":"additional","affiliation":[{"name":"From the Service de Cardiologie, P\u00f4le C\u0153ur Thorax Vasculaire, Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine, Universit\u00e9 Fran\u00e7ois Rabelais, Tours, France (L.F., N.C.); Medtronic France, Boulogne-Billancourt, France (C.P., C.C.); Medtronic Europe, Tolochenaz, Switzerland (E.N.); and University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom (G.Y.H.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.111.962688"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs253"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/hs1201.100209"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70310-7"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105575"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.06.034"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.029801"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1313600"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.22.2864"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1584"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.11.122"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.12.011"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.09.148"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.05.023"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0435"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-305303"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2008.07.013"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.11.015"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2010.11.012"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12143"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001874"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510350050036"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80348-9"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.7.2455"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1159\/000353670"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-11-0692"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318287281b"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.03.004"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60443-8"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2888"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-0321"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311376"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.115.010270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:09:29Z","timestamp":1715609369000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.115.010270"}},"subtitle":["A Nationwide Cohort Study"],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1161\/STROKEAHA.115.010270"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.115.010270","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"2015-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}