{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T19:47:09Z","timestamp":1778960829661,"version":"3.51.4"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Exhaled carbon monoxide (CO) is associated with cardiometabolic traits, subclinical atherosclerosis, and cardiovascular disease, but its specific relations with stroke are unexplored. We related exhaled CO to magnetic resonance imaging measures of subclinical cerebrovascular disease cross-sectionally and to incident stroke\/transient ischemic attack prospectively in the Framingham Offspring study.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>We measured exhaled CO in 3313 participants (age 59\u00b110 years; 53% women), and brain magnetic resonance imaging was available in 1982 individuals (age 58\u00b110 years; 54% women). Participants were analyzed according to tertiles of exhaled CO concentration.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              In age- and sex-adjusted models, the highest tertile of exhaled CO was associated with lower total cerebral brain volumes, higher white-matter hyperintensity volumes, and greater prevalence of silent cerebral infarcts (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05 for all). The results for total cerebral brain volume and white-matter hyperintensity volume were consistent after removing smokers from the sample, and the association with white-matter hyperintensity volume persisted after multivariable adjustment (\n              <jats:italic>P<\/jats:italic>\n              =0.04). In prospective analyses (mean follow-up 12.9 years), higher exhaled CO was associated with 67% (second tertile) and 97% (top tertile) increased incidence of stroke\/transient ischemic attack relative to the first tertile that served as referent (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01 for both). These results were consistent in nonsmokers and were partially attenuated upon adjustment for vascular risk factors.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>In this large, community-based sample of individuals without clinical stroke\/transient ischemic attack at baseline, higher exhaled CO was associated with a greater burden of subclinical cerebrovascular disease cross-sectionally and with increased risk of stroke\/transient ischemic attack prospectively. Further investigation is necessary to explore the biological mechanisms linking elevated CO with stroke.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.115.010405","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T02:19:54Z","timestamp":1450837194000},"page":"383-389","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Association of Exhaled Carbon Monoxide With Stroke Incidence and Subclinical Vascular Brain Injury"],"prefix":"10.1161","volume":"47","author":[{"given":"Matthew","family":"Nayor","sequence":"first","affiliation":[{"name":"From the Framingham Heart Study, MA (M.N., A.S.B., S.C., R.S.V., S.S.); Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Boston, MA (M.N., S.C.); Departments of Biostatistics (D.M.E., A.S.B.) and Epidemiology (R.S.V.), Boston University School of Public Health, MA; Department of Neurology (A.S.B., S.S) and Sections of Preventive Medicine &amp; Epidemiology and Cardiology, Department of Medicine (R.S.V.), Boston University School of Medicine, MA; and Department of Neurology and..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle M.","family":"Enserro","sequence":"additional","affiliation":[{"name":"From the Framingham Heart Study, MA (M.N., A.S.B., S.C., R.S.V., S.S.); Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Boston, MA (M.N., S.C.); Departments of Biostatistics (D.M.E., A.S.B.) and Epidemiology (R.S.V.), Boston University School of Public Health, MA; Department of Neurology (A.S.B., S.S) and Sections of Preventive Medicine &amp; Epidemiology and Cardiology, Department of Medicine (R.S.V.), Boston University School of Medicine, MA; and Department of Neurology and..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexa S.","family":"Beiser","sequence":"additional","affiliation":[{"name":"From the Framingham Heart Study, MA (M.N., A.S.B., S.C., R.S.V., S.S.); Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Boston, MA (M.N., S.C.); Departments of Biostatistics (D.M.E., A.S.B.) and Epidemiology (R.S.V.), Boston University School of Public Health, MA; Department of Neurology (A.S.B., S.S) and Sections of Preventive Medicine &amp; Epidemiology and Cardiology, Department of Medicine (R.S.V.), Boston University School of Medicine, MA; and Department of Neurology and..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Cheng","sequence":"additional","affiliation":[{"name":"From the Framingham Heart Study, MA (M.N., A.S.B., S.C., R.S.V., S.S.); Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Boston, MA (M.N., S.C.); Departments of Biostatistics (D.M.E., A.S.B.) and Epidemiology (R.S.V.), Boston University School of Public Health, MA; Department of Neurology (A.S.B., S.S) and Sections of Preventive Medicine &amp; Epidemiology and Cardiology, Department of Medicine (R.S.V.), Boston University School of Medicine, MA; and Department of Neurology and..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"DeCarli","sequence":"additional","affiliation":[{"name":"From the Framingham Heart Study, MA (M.N., A.S.B., S.C., R.S.V., S.S.); Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Boston, MA (M.N., S.C.); Departments of Biostatistics (D.M.E., A.S.B.) and Epidemiology (R.S.V.), Boston University School of Public Health, MA; Department of Neurology (A.S.B., S.S) and Sections of Preventive Medicine &amp; Epidemiology and Cardiology, Department of Medicine (R.S.V.), Boston University School of Medicine, MA; and Department of Neurology and..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramachandran S.","family":"Vasan","sequence":"additional","affiliation":[{"name":"From the Framingham Heart Study, MA (M.N., A.S.B., S.C., R.S.V., S.S.); Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Boston, MA (M.N., S.C.); Departments of Biostatistics (D.M.E., A.S.B.) and Epidemiology (R.S.V.), Boston University School of Public Health, MA; Department of Neurology (A.S.B., S.S) and Sections of Preventive Medicine &amp; Epidemiology and Cardiology, Department of Medicine (R.S.V.), Boston University School of Medicine, MA; and Department of Neurology and..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudha","family":"Seshadri","sequence":"additional","affiliation":[{"name":"From the Framingham Heart Study, MA (M.N., A.S.B., S.C., R.S.V., S.S.); Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Boston, MA (M.N., S.C.); Departments of Biostatistics (D.M.E., A.S.B.) and Epidemiology (R.S.V.), Boston University School of Public Health, MA; Department of Neurology (A.S.B., S.S) and Sections of Preventive Medicine &amp; Epidemiology and Cardiology, Department of Medicine (R.S.V.), Boston University School of Medicine, MA; and Department of Neurology and..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61689-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61728-0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.9.1840"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60834-3"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60694-7"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000152"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gheart.2014.01.001"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv114"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.887695"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm817"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607610200"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2013.61"},{"issue":"6","key":"e_1_3_3_14_2","first-page":"F882","article-title":"Carbon monoxide induces vasodilation and nitric oxide release but suppresses endothelial NOS.","volume":"277","author":"Thorup C","year":"1999","unstructured":"Thorup C, Jones CL, Gross SS, Moore LC, Goligorsky MS. Carbon monoxide induces vasodilation and nitric oxide release but suppresses endothelial NOS. Am J Physiol. 1999;277(6 Pt 2):F882\u2013F889.","journal-title":"Am J Physiol"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.1.66"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx970041h"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.83.5.568"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00308.2005"},{"key":"e_1_3_3_19_2","first-page":"553","article-title":"The relationship between alveolar and blood carbon monoxide concentrations during breathholding; simple estimation of COHb saturation.","volume":"51","author":"Jones RH","year":"1958","unstructured":"Jones RH, Ellicott MF, Cadigan JB, Gaensler EA. The relationship between alveolar and blood carbon monoxide concentrations during breathholding; simple estimation of COHb saturation. J Lab Clin Med. 1958;51:553\u2013564.","journal-title":"J Lab Clin Med"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.116.4.1007"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.941013"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu052"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112813"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.10.005"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2004.05.004"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000135226.53499.85"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.3.312"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-8-S1-S15"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4165"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.20.10925"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3228"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2010.07.011"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1305"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00011.2005"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1174-9"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3530475"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.6.1923"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.05.057"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.04.043"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn232"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10661-014-4013-1"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.3155\/1047-3289.60.3.328"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1080\/10937404.2012.710134"},{"key":"e_1_3_3_44_2","unstructured":"Cabon Monoxide: National Trends in CO Levels. Environmental Protection Agency Website. Available at: http:\/\/www.epa.gov\/airtrends\/carbon.html. Accessed July 13 2015."},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.7.1145"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.115.010405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:25:45Z","timestamp":1715610345000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.115.010405"}},"subtitle":["Framingham Heart Study"],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1161\/STROKEAHA.115.010405"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.115.010405","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"2015-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}