{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:48:55Z","timestamp":1788922135782,"version":"build-2803163510"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Emerging work has linked menopausal vasomotor symptoms (VMS) to subclinical cardiovascular disease (CVD) among women. However, VMS are dynamic over time. No studies have considered how temporal patterns of VMS may relate to subclinical CVD. We tested how temporal patterns of VMS assessed over 13 years were related to carotid intima media thickness (IMT) among midlife women.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>The Study of Women\u2019s Health Across the Nation is a longitudinal cohort study of midlife women. Eight hundred and eleven white, black, Hispanic, and Chinese participants with a well-characterized final menstrual period completed measures of VMS, a blood draw, and physical measures approximately annually for 13 years. Women underwent a carotid artery ultrasound at study visit 12.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Four trajectories of VMS were identified by trajectory analysis (consistently high, early-onset, late-onset, persistently low VMS) and tested in relation to carotid indices in linear regression models. Results indicated that women with early-onset VMS had both greater mean IMT (beta, b [standard error, SE]=0.03 [0.01],\n              <jats:italic>P<\/jats:italic>\n              =0.03) and greater maximal IMT (b [SE]=0.04 [0.01],\n              <jats:italic>P<\/jats:italic>\n              =0.008) than women with consistently low VMS, adjusting for demographics and CVD risk factors.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>This is the first study to test trajectories of VMS in relation to subclinical CVD. Women with VMS early in the menopause transition had higher mean IMT and maximal IMT than those with consistently low VMS across the transition. Associations were not accounted for by demographic factors nor by CVD risk factors. Results can signal to women in need of early CVD risk reduction.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.115.010600","type":"journal-article","created":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T03:29:14Z","timestamp":1447817354000},"page":"12-17","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":83,"title":["Trajectories of Vasomotor Symptoms and Carotid Intima Media Thickness in the Study of Women\u2019s Health Across the Nation"],"prefix":"10.1161","volume":"47","author":[{"given":"Rebecca C.","family":"Thurston","sequence":"first","affiliation":[{"name":"From the Department of Psychiatry, University of Pittsburgh School of Medicine (R.C.T., K.A.M.), Department of Epidemiology, University of Pittsburgh Graduate School of Public Health (R.C.T., S.R.E.K., P.G.T., H.-Y.C., K.A.M.), PA; Department of Medicine, Division of Cardiovascular Medicine, University of Michigan School of Medicine, Ann Arbor (E.A.J.); and Department of Psychiatry, Brigham and Women\u2019s Hospital and Dana Farber Cancer Institute, Boston, MA (H.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar R.","family":"El Khoudary","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry, University of Pittsburgh School of Medicine (R.C.T., K.A.M.), Department of Epidemiology, University of Pittsburgh Graduate School of Public Health (R.C.T., S.R.E.K., P.G.T., H.-Y.C., K.A.M.), PA; Department of Medicine, Division of Cardiovascular Medicine, University of Michigan School of Medicine, Ann Arbor (E.A.J.); and Department of Psychiatry, Brigham and Women\u2019s Hospital and Dana Farber Cancer Institute, Boston, MA (H.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping Guo","family":"Tepper","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry, University of Pittsburgh School of Medicine (R.C.T., K.A.M.), Department of Epidemiology, University of Pittsburgh Graduate School of Public Health (R.C.T., S.R.E.K., P.G.T., H.-Y.C., K.A.M.), PA; Department of Medicine, Division of Cardiovascular Medicine, University of Michigan School of Medicine, Ann Arbor (E.A.J.); and Department of Psychiatry, Brigham and Women\u2019s Hospital and Dana Farber Cancer Institute, Boston, MA (H.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Jackson","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry, University of Pittsburgh School of Medicine (R.C.T., K.A.M.), Department of Epidemiology, University of Pittsburgh Graduate School of Public Health (R.C.T., S.R.E.K., P.G.T., H.-Y.C., K.A.M.), PA; Department of Medicine, Division of Cardiovascular Medicine, University of Michigan School of Medicine, Ann Arbor (E.A.J.); and Department of Psychiatry, Brigham and Women\u2019s Hospital and Dana Farber Cancer Institute, Boston, MA (H.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadine","family":"Joffe","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry, University of Pittsburgh School of Medicine (R.C.T., K.A.M.), Department of Epidemiology, University of Pittsburgh Graduate School of Public Health (R.C.T., S.R.E.K., P.G.T., H.-Y.C., K.A.M.), PA; Department of Medicine, Division of Cardiovascular Medicine, University of Michigan School of Medicine, Ann Arbor (E.A.J.); and Department of Psychiatry, Brigham and Women\u2019s Hospital and Dana Farber Cancer Institute, Boston, MA (H.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang-Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry, University of Pittsburgh School of Medicine (R.C.T., K.A.M.), Department of Epidemiology, University of Pittsburgh Graduate School of Public Health (R.C.T., S.R.E.K., P.G.T., H.-Y.C., K.A.M.), PA; Department of Medicine, Division of Cardiovascular Medicine, University of Michigan School of Medicine, Ann Arbor (E.A.J.); and Department of Psychiatry, Brigham and Women\u2019s Hospital and Dana Farber Cancer Institute, Boston, MA (H.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A.","family":"Matthews","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry, University of Pittsburgh School of Medicine (R.C.T., K.A.M.), Department of Epidemiology, University of Pittsburgh Graduate School of Public Health (R.C.T., S.R.E.K., P.G.T., H.-Y.C., K.A.M.), PA; Department of Medicine, Division of Cardiovascular Medicine, University of Michigan School of Medicine, Ann Arbor (E.A.J.); and Department of Psychiatry, Brigham and Women\u2019s Hospital and Dana Farber Cancer Institute, Boston, MA (H.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Appendix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siob\u00e1n","family":"Harlow","sequence":"additional","affiliation":[{"name":"University of Michigan, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MaryFran","family":"Sowers","sequence":"additional","affiliation":[{"name":"University of Michigan, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Finkelstein","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Neer","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Kravitz","sequence":"additional","affiliation":[{"name":"Rush University, Rush University Medical Center, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Powell","sequence":"additional","affiliation":[{"name":"Rush University, Rush University Medical Center, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Gold","sequence":"additional","affiliation":[{"name":"University of California, Davis\/Kaiser"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Greendale","sequence":"additional","affiliation":[{"name":"UCLA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Derby","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Bronx, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Wildman","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Bronx, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanette","family":"Santoro","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Bronx, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerson","family":"Weiss","sequence":"additional","affiliation":[{"name":"University of Medicine and Dentistry\u2013NJ Medical School, Newark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winifred","family":"Rossi","sequence":"additional","affiliation":[{"name":"NIA, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry","family":"Sherman","sequence":"additional","affiliation":[{"name":"NIA, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"Ory","sequence":"additional","affiliation":[{"name":"NIA, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"McConnell","sequence":"additional","affiliation":[{"name":"University of Michigan, Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Mori","family":"Brooks","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Sutton-Tyrrell","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"McKinlay","sequence":"additional","affiliation":[{"name":"New England Research Institutes, Watertown, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Johnson","sequence":"additional","affiliation":[{"name":"Current Chair"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Former Chair"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.968792"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2005.066936"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181a3cdaf"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.776823"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181fa27fd"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181c1ad3d"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2262"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.106526"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31824a09ec"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1410"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31819cac04"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3182014849"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318214f0de"},{"key":"e_1_3_5_15_2","first-page":"1356","article-title":"Trajectory patterns of vasomotor symptoms over the menopausal transition in the Study of Women\u2019s Health Across the Nation (abstract).","volume":"20","author":"Tepper P","year":"2013","unstructured":"Tepper P, Randolph J, Jones B, Crawford S, Gold E, El, Khoudary S, et al.. Trajectory patterns of vasomotor symptoms over the menopausal transition in the Study of Women\u2019s Health Across the Nation (abstract). Menopause 2013;20:1356.","journal-title":"Menopause"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2007.11.011"},{"key":"e_1_3_5_17_2","first-page":"175","volume-title":"In: Menopause: Biology and Pathology","author":"Sowers M","year":"2000","unstructured":"Sowers M, Crawford S, Sternfeld B, Morganstein D, Gold EB, Greendale GA, et al.. Swan: A multicenter, multiethnic, community-based cohort study of women and the menopausal transition. , Lobo RA, Kelsey J, Marcus R, Lobo AR, In: Menopause: Biology and Pathology. New York: Academic Press; 2000:175\u2013188."},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.1991.tb00676.x"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.2.215"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.121208.131413"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.6.1491"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.07.025"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2011.618564"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181e664dc"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2010.11.016"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/152460901750067133"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.05.005"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3182337166"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e31821f5d39"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.18085"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.04.052"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.115.010600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:26:14Z","timestamp":1715610374000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.115.010600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1161\/STROKEAHA.115.010600"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.115.010600","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2015-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}