{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:16:25Z","timestamp":1782738985629,"version":"3.54.5"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Three-dimensional pseudocontinuous arterial spin labeling with multiple postlabeling delays has been used to assess cerebral blood flow (CBF). We used this modality to estimate antegrade and collateral flow in patients with unilateral middle cerebral artery stenosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Consecutive patients with unilateral middle cerebral artery 50% to 99% stenosis at 2 centers underwent pseudocontinuous arterial spin labeling with a postlabeling delays of 1.5 and 2.5 s. Mean CBF of bilateral middle cerebral artery territory at the postlabeling delays 1.5 and 2.5 s was measured. Early-arriving flow proportion was defined as (CBF 1.5 s at lesion side\/CBF 2.5 s at normal side)\u00d7100%. Late-arriving retrograde flow proportion was defined as ([CBF 2.5 s\u2212CBF 1.5 s] at lesion side\u2212[CBF 2.5 s\u2212CBF 1.5 s] at normal side)\/CBF 2.5 s at normal side\u00d7100%. Antegrade and collateral scales were evaluated in patients with conventional angiography. Spearman correlation coefficients were calculated between early-arriving flow and late-arriving retrograde flow proportions on arterial spin labeling and antegrade and collateral scales on conventional angiography, respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Forty-one patients (46.0\u00b112.0 years) were enrolled. The mean early-arriving flow proportion was 78.3\u00b114.9%. The mean late-arriving retrograde flow proportion was 16.1\u00b110.2%. In 21 patients with conventional angiography, Spearman correlation coefficient was 0.53 (95% confidence interval, 0.11\u20130.79) between antegrade grade and early-arriving flow proportion (\n              <jats:italic>P<\/jats:italic>\n              =0.01) and 0.81 (95% confidence interval, 0.56\u20130.92) between collateral grade and late-arriving retrograde flow proportion (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Three-dimensional pseudocontinuous arterial spin labeling with 2 postlabeling delays may provide an empirical approach for estimating antegrade and collateral flow in patients with unilateral middle cerebral artery stenosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT02479243.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.115.011057","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T21:36:01Z","timestamp":1453757761000},"page":"428-433","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":56,"title":["Arterial Spin Labeling Magnetic Resonance Imaging Estimation of Antegrade and Collateral Flow in Unilateral Middle Cerebral Artery Stenosis"],"prefix":"10.1161","volume":"47","author":[{"given":"Jinhao","family":"Lyu","sequence":"first","affiliation":[{"name":"From the Department of Radiology, Chinese PLA General Hospital, Beijing, China (J.L., L.M., Y.X., T.W., X.L.); Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (N.M., Z.M.); and Department of Neurology, UCLA Stroke Center, Los Angeles (D.S.L., D.J.J.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Ma","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Chinese PLA General Hospital, Beijing, China (J.L., L.M., Y.X., T.W., X.L.); Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (N.M., Z.M.); and Department of Neurology, UCLA Stroke Center, Los Angeles (D.S.L., D.J.J.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Liebeskind","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Chinese PLA General Hospital, Beijing, China (J.L., L.M., Y.X., T.W., X.L.); Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (N.M., Z.M.); and Department of Neurology, UCLA Stroke Center, Los Angeles (D.S.L., D.J.J.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny J.J.","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Chinese PLA General Hospital, Beijing, China (J.L., L.M., Y.X., T.W., X.L.); Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (N.M., Z.M.); and Department of Neurology, UCLA Stroke Center, Los Angeles (D.S.L., D.J.J.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ma","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Chinese PLA General Hospital, Beijing, China (J.L., L.M., Y.X., T.W., X.L.); Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (N.M., Z.M.); and Department of Neurology, UCLA Stroke Center, Los Angeles (D.S.L., D.J.J.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xu","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Chinese PLA General Hospital, Beijing, China (J.L., L.M., Y.X., T.W., X.L.); Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (N.M., Z.M.); and Department of Neurology, UCLA Stroke Center, Los Angeles (D.S.L., D.J.J.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Chinese PLA General Hospital, Beijing, China (J.L., L.M., Y.X., T.W., X.L.); Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (N.M., Z.M.); and Department of Neurology, UCLA Stroke Center, Los Angeles (D.S.L., D.J.J.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongrong","family":"Miao","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Chinese PLA General Hospital, Beijing, China (J.L., L.M., Y.X., T.W., X.L.); Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (N.M., Z.M.); and Department of Neurology, UCLA Stroke Center, Los Angeles (D.S.L., D.J.J.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lou","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, Chinese PLA General Hospital, Beijing, China (J.L., L.M., Y.X., T.W., X.L.); Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (N.M., Z.M.); 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