{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:24:10Z","timestamp":1780601050397,"version":"3.54.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Demographic trends in atrial fibrillation (AF) incidence may yield a substantial rise in the societal burden of AF-related stroke (AF-stroke). Accurate population-wide outcome data are essential to inform health service planning to improve AF-stroke prevention, and provision of rehabilitation, nursing home, and community supports for AF-stroke survivors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>We investigated rates and determinants of 5-year fatality, stroke recurrence, functional outcomes, and prescribing of secondary prevention medications in AF-stroke in the North Dublin Population Stroke Study. Ascertainment included hot and cold pursuit using multiple overlapping sources. Survival analysis was performed using lifetables and Kaplan\u2013Meier survival curves, and Cox proportional hazard modeling was performed to identify predictors of death and recurrent stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Five hundred sixty-eight patients with new stroke were identified, including 177 (31.2%) AF-stroke. At 5 years, 39.2% (confidence interval, 31.5\u201346.8) of ischemic AF-stroke patients were alive. Congestive heart failure, hypertension, age &lt;65, 65\u201374 years, and \u226575 years, diabetes mellitus, prior stroke, transient ischemic attack or thromboembolism, vascular disease and female sex (CHA\n              <jats:sub>2<\/jats:sub>\n              DS\n              <jats:sub>2<\/jats:sub>\n              -VASc) score (hazard ratio [HR], 1.34;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), CHADS\n              <jats:sub>2<\/jats:sub>\n              score (HR 1.42,\n              <jats:italic>P<\/jats:italic>\n              =0.004), National Institute of Health Stroke Scale (HR, 1.09;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001), and subtherapeutic international normalized ratio (&lt;2.0) at stroke onset (HR, 3.29;\n              <jats:italic>P<\/jats:italic>\n              =0.003) were independently associated with 5-year fatality, whereas warfarin (HR, 0.40;\n              <jats:italic>P<\/jats:italic>\n              =0.001) and statin use after index stroke (HR, 0.52;\n              <jats:italic>P<\/jats:italic>\n              =0.005) were associated with improved survival. The 5-year recurrence rate after ischemic AF-stroke was 21.5% (confidence interval, 14.5\u201331.3). Trends toward greater risk of recurrence were observed for persistent AF (HR, 3.09;\n              <jats:italic>P<\/jats:italic>\n              =0.07) and CHA\n              <jats:sub>2<\/jats:sub>\n              DS\n              <jats:sub>2<\/jats:sub>\n              -VASc score (HR, 1.34;\n              <jats:italic>P<\/jats:italic>\n              =0.07). Nursing home care was needed for 25.9% of patients.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>AF-stroke is associated with considerable long-term morbidity, fatality, stroke recurrence, and nursing home requirement. Adequately resourced national AF strategies to improve AF detection and prevention are needed.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.115.011139","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T02:48:37Z","timestamp":1444963717000},"page":"3488-3493","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":79,"title":["Rates and Determinants of 5-Year Outcomes After Atrial Fibrillation\u2013Related Stroke"],"prefix":"10.1161","volume":"46","author":[{"given":"Derek T.","family":"Hayden","sequence":"first","affiliation":[{"name":"From the Stroke Department (D.T.H., E.C., D.N.C., G.H., K.O., S.M., P.J.K.), and Geriatrics Department (L.K., J.D.), Neurovascular Unit for Applied Translational Research and Therapeutics, University College Dublin\/Dublin Academic Medical Centre, Mater University Hospital, Dublin, Ireland; Stroke Department, Beaumont University Hospital, Dublin, Ireland (D.W.); Stroke Department, Connolly Hospital Blanchardstown, Dublin, Ireland (E.C., E.D.); Department of Neurosciences, Addenbrookes Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niamh","family":"Hannon","sequence":"additional","affiliation":[{"name":"From the Stroke Department (D.T.H., E.C., D.N.C., G.H., K.O., S.M., P.J.K.), and Geriatrics Department (L.K., J.D.), Neurovascular Unit for Applied Translational Research and Therapeutics, University College Dublin\/Dublin Academic Medical Centre, Mater University Hospital, Dublin, Ireland; Stroke Department, Beaumont University Hospital, Dublin, Ireland (D.W.); Stroke Department, Connolly Hospital Blanchardstown, Dublin, Ireland (E.C., E.D.); Department of Neurosciences, Addenbrookes Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Callaly","sequence":"additional","affiliation":[{"name":"From the Stroke Department (D.T.H., E.C., D.N.C., G.H., K.O., S.M., P.J.K.), and Geriatrics Department (L.K., J.D.), Neurovascular Unit for Applied Translational Research and Therapeutics, University College Dublin\/Dublin Academic Medical Centre, Mater University Hospital, Dublin, Ireland; Stroke Department, Beaumont University Hospital, Dublin, Ireland (D.W.); Stroke Department, Connolly Hospital Blanchardstown, Dublin, Ireland (E.C., E.D.); Department of Neurosciences, Addenbrookes Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"N\u00ed Chr\u00f3in\u00edn","sequence":"additional","affiliation":[{"name":"From the Stroke Department (D.T.H., E.C., D.N.C., G.H., K.O., S.M., P.J.K.), and Geriatrics Department (L.K., J.D.), Neurovascular Unit for Applied Translational Research and Therapeutics, University College Dublin\/Dublin Academic Medical Centre, Mater University Hospital, Dublin, Ireland; Stroke Department, Beaumont University Hospital, Dublin, Ireland (D.W.); Stroke Department, Connolly Hospital Blanchardstown, Dublin, Ireland (E.C., E.D.); Department of Neurosciences, Addenbrookes Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Horgan","sequence":"additional","affiliation":[{"name":"From the Stroke Department (D.T.H., E.C., D.N.C., G.H., K.O., S.M., P.J.K.), and Geriatrics Department (L.K., J.D.), Neurovascular Unit for Applied Translational Research and Therapeutics, University College Dublin\/Dublin Academic Medical Centre, Mater University Hospital, Dublin, Ireland; Stroke Department, Beaumont University Hospital, Dublin, Ireland (D.W.); Stroke Department, Connolly Hospital Blanchardstown, Dublin, Ireland (E.C., E.D.); Department of Neurosciences, Addenbrookes Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Kyne","sequence":"additional","affiliation":[{"name":"From the Stroke Department (D.T.H., E.C., D.N.C., G.H., K.O., S.M., P.J.K.), and Geriatrics Department (L.K., J.D.), Neurovascular Unit for Applied Translational Research and Therapeutics, University College Dublin\/Dublin Academic Medical Centre, Mater University Hospital, Dublin, Ireland; Stroke Department, Beaumont University Hospital, Dublin, Ireland (D.W.); Stroke Department, Connolly Hospital Blanchardstown, Dublin, Ireland (E.C., E.D.); Department of Neurosciences, Addenbrookes Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Duggan","sequence":"additional","affiliation":[{"name":"From the Stroke Department (D.T.H., E.C., D.N.C., G.H., K.O., S.M., P.J.K.), and Geriatrics Department (L.K., J.D.), Neurovascular Unit for Applied Translational Research and Therapeutics, University College Dublin\/Dublin Academic Medical Centre, Mater University Hospital, Dublin, Ireland; Stroke Department, Beaumont University Hospital, Dublin, Ireland (D.W.); Stroke Department, Connolly Hospital Blanchardstown, Dublin, Ireland (E.C., E.D.); Department of Neurosciences, Addenbrookes Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eamon","family":"Dolan","sequence":"additional","affiliation":[{"name":"From the Stroke Department (D.T.H., E.C., D.N.C., G.H., K.O., S.M., P.J.K.), and Geriatrics Department (L.K., J.D.), Neurovascular Unit for Applied Translational Research and Therapeutics, University College Dublin\/Dublin Academic Medical Centre, Mater University Hospital, Dublin, Ireland; Stroke Department, Beaumont University Hospital, Dublin, Ireland (D.W.); Stroke Department, Connolly Hospital Blanchardstown, Dublin, Ireland (E.C., E.D.); Department of Neurosciences, Addenbrookes Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Killian","family":"O\u2019Rourke","sequence":"additional","affiliation":[{"name":"From the Stroke Department (D.T.H., E.C., D.N.C., G.H., K.O., S.M., P.J.K.), and Geriatrics Department (L.K., J.D.), Neurovascular Unit for Applied Translational Research and Therapeutics, University College Dublin\/Dublin Academic Medical Centre, Mater University Hospital, Dublin, Ireland; Stroke Department, Beaumont University Hospital, Dublin, Ireland (D.W.); Stroke Department, Connolly Hospital Blanchardstown, Dublin, Ireland (E.C., E.D.); Department of Neurosciences, Addenbrookes Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Williams","sequence":"additional","affiliation":[{"name":"From the Stroke Department (D.T.H., E.C., D.N.C., G.H., K.O., S.M., P.J.K.), and Geriatrics Department (L.K., J.D.), Neurovascular Unit for Applied Translational Research and Therapeutics, University College Dublin\/Dublin Academic Medical Centre, Mater University Hospital, Dublin, Ireland; Stroke Department, Beaumont University Hospital, Dublin, Ireland (D.W.); Stroke Department, Connolly Hospital Blanchardstown, Dublin, Ireland (E.C., E.D.); Department of Neurosciences, Addenbrookes Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Murphy","sequence":"additional","affiliation":[{"name":"From the Stroke Department (D.T.H., E.C., D.N.C., G.H., K.O., S.M., P.J.K.), and Geriatrics Department (L.K., J.D.), Neurovascular Unit for Applied Translational Research and Therapeutics, University College Dublin\/Dublin Academic Medical Centre, Mater University Hospital, Dublin, Ireland; Stroke Department, Beaumont University Hospital, Dublin, Ireland (D.W.); Stroke Department, Connolly Hospital Blanchardstown, Dublin, Ireland (E.C., E.D.); Department of Neurosciences, Addenbrookes Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Kelly","sequence":"additional","affiliation":[{"name":"From the Stroke Department (D.T.H., E.C., D.N.C., G.H., K.O., S.M., P.J.K.), and Geriatrics Department (L.K., J.D.), Neurovascular Unit for Applied Translational Research and Therapeutics, University College Dublin\/Dublin Academic Medical Centre, Mater University Hospital, Dublin, Ireland; Stroke Department, Beaumont University Hospital, Dublin, Ireland (D.W.); Stroke Department, Connolly Hospital Blanchardstown, Dublin, Ireland (E.C., E.D.); Department of Neurosciences, Addenbrookes Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.535088"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.645721"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.18.2370"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.010942"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.012738"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000166053.83476.4a"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000255973"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.2.169"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005960"},{"key":"e_1_3_4_11_2","volume-title":"Census of Population of Ireland 2006","author":"Central statistics office Ireland","year":"2007","unstructured":"Central statistics office Ireland. 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