{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:04:39Z","timestamp":1787069079666,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>Chronic cerebral hypoperfusion can lead to ischemic white matter injury resulting in vascular dementia. To characterize white matter injury in vascular dementia, we investigated disintegration of diverse white matter components using a rat model of chronic cerebral hypoperfusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>Chronic cerebral hypoperfusion was modeled in Wistar rats by permanent occlusion of the bilateral common carotid arteries. We performed cognitive behavioral tests, including the water maze task, odor discrimination task, and novel object test; histological investigation of neuroinflammation, oligodendrocytes, myelin basic protein, and nodal or paranodal proteins at the nodes of Ranvier; and serial diffusion tensor imaging. Cilostazol was administered to protect against white matter injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>Diverse cognitive impairments were induced by chronic cerebral hypoperfusion. Disintegration of white matter was characterized by neuroinflammation, loss of oligodendrocytes, attenuation of myelin density, structural derangement at the nodes of Ranvier, and disintegration of white matter tracts. Cilostazol protected against cognitive impairments and white matter disintegration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>White matter injury induced by chronic cerebral hypoperfusion can be characterized by disintegration of diverse white matter components. Cilostazol might be a therapeutic strategy against white matter disintegration in patients with vascular dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.115.011679","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T22:38:59Z","timestamp":1450219139000},"page":"542-547","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":104,"title":["Characterization of White Matter Injury in a Rat Model of Chronic Cerebral Hypoperfusion"],"prefix":"10.1161","volume":"47","author":[{"given":"Bo-Ryoung","family":"Choi","sequence":"first","affiliation":[{"name":"From the Department of Neurology (B.-R.C., D.B.B., K.J.K., S.-H.H., H.Y.K.), Department of Biological Sciences (B.-R.C., D.-H.K., J.-S.H.), Department of Radiology (C.H.K., W.-J.M.), Department of Medicine (D.-H.C.), Department of Pharmacology (C.Y.S.), and Department of Rehabilitation Medicine (B.-R.K., J.L.), Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (B.-R.C., D.B.B., K.J.K., S.-H.H., H.Y.K.), Department of Biological Sciences (B.-R.C., D.-H.K., J.-S.H.), Department of Radiology (C.H.K., W.-J.M.), Department of Medicine (D.-H.C.), Department of Pharmacology (C.Y.S.), and Department of Rehabilitation Medicine (B.-R.K., J.L.), Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Bin","family":"Back","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (B.-R.C., D.B.B., K.J.K., S.-H.H., H.Y.K.), Department of Biological Sciences (B.-R.C., D.-H.K., J.-S.H.), Department of Radiology (C.H.K., W.-J.M.), Department of Medicine (D.-H.C.), Department of Pharmacology (C.Y.S.), and Department of Rehabilitation Medicine (B.-R.K., J.L.), Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung Hwan","family":"Kang","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (B.-R.C., D.B.B., K.J.K., S.-H.H., H.Y.K.), Department of Biological Sciences (B.-R.C., D.-H.K., J.-S.H.), Department of Radiology (C.H.K., W.-J.M.), Department of Medicine (D.-H.C.), Department of Pharmacology (C.Y.S.), and Department of Rehabilitation Medicine (B.-R.K., J.L.), Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Jin","family":"Moon","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (B.-R.C., D.B.B., K.J.K., S.-H.H., H.Y.K.), Department of Biological Sciences (B.-R.C., D.-H.K., J.-S.H.), Department of Radiology (C.H.K., W.-J.M.), Department of Medicine (D.-H.C.), Department of Pharmacology (C.Y.S.), and Department of Rehabilitation Medicine (B.-R.K., J.L.), Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Soo","family":"Han","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (B.-R.C., D.B.B., K.J.K., S.-H.H., H.Y.K.), Department of Biological Sciences (B.-R.C., D.-H.K., J.-S.H.), Department of Radiology (C.H.K., W.-J.M.), Department of Medicine (D.-H.C.), Department of Pharmacology (C.Y.S.), and Department of Rehabilitation Medicine (B.-R.K., J.L.), Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Hee","family":"Choi","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (B.-R.C., D.B.B., K.J.K., S.-H.H., H.Y.K.), Department of Biological Sciences (B.-R.C., D.-H.K., J.-S.H.), Department of Radiology (C.H.K., W.-J.M.), Department of Medicine (D.-H.C.), Department of Pharmacology (C.Y.S.), and Department of Rehabilitation Medicine (B.-R.K., J.L.), Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Ja","family":"Kwon","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (B.-R.C., D.B.B., K.J.K., S.-H.H., H.Y.K.), Department of Biological Sciences (B.-R.C., D.-H.K., J.-S.H.), Department of Radiology (C.H.K., W.-J.M.), Department of Medicine (D.-H.C.), Department of Pharmacology (C.Y.S.), and Department of Rehabilitation Medicine (B.-R.K., J.L.), Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Young","family":"Shin","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (B.-R.C., D.B.B., K.J.K., S.-H.H., H.Y.K.), Department of Biological Sciences (B.-R.C., D.-H.K., J.-S.H.), Department of Radiology (C.H.K., W.-J.M.), Department of Medicine (D.-H.C.), Department of Pharmacology (C.Y.S.), and Department of Rehabilitation Medicine (B.-R.K., J.L.), Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Ram","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (B.-R.C., D.B.B., K.J.K., S.-H.H., H.Y.K.), Department of Biological Sciences (B.-R.C., D.-H.K., J.-S.H.), Department of Radiology (C.H.K., W.-J.M.), 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