{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:12:36Z","timestamp":1792512756942,"version":"4.5.0"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Our aim was to study the efficacy of robotic therapy as an adjuvant to standard therapy during poststroke rehabilitation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Prospective, open, blinded end point, randomized, multicenter exploratory clinical trial in Japan of 60 individuals with mild to moderate hemiplegia 4 to 8 weeks post stroke randomized to receive standard therapy plus 40 minutes of either robotic or self-guided therapy for 6 weeks (7 days\/week). Upper extremity impairment before and after intervention was measured using the Fugl\u2013Meyer assessment, Wolf Motor Function Test, and Motor Activity Log.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Robotic therapy significantly improved Fugl\u2013Meyer assessment flexor synergy (2.1\u00b12.7 versus \u22120.1\u00b12.4;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01) and proximal upper extremity (4.8\u00b15.0 versus 1.9\u00b15.5;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05) compared with self-guided therapy. No significant changes in Wolf Motor Function Test or Motor Activity Log were observed. Robotic therapy also significantly improved Fugl\u2013Meyer assessment proximal upper extremity among low-functioning patients (baseline Fugl\u2013Meyer assessment score &lt;30) and among patients with Wolf Motor Function Test \u2265120 at baseline compared with self-guided therapy (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05 for both).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Robotic therapy as an adjuvant to standard rehabilitation may improve upper extremity recovery in moderately impaired poststroke patients. Results of this exploratory study should be interpreted with caution.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.umin.ac.jp\/\">http:\/\/www.umin.ac.jp\/<\/jats:ext-link>\n              . Unique identifier: UMIN000001619.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.115.012520","type":"journal-article","created":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T03:49:56Z","timestamp":1458704996000},"page":"1385-1388","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":99,"title":["Efficacy of Upper Extremity Robotic Therapy in Subacute Poststroke Hemiplegia"],"prefix":"10.1161","volume":"47","author":[{"given":"Kayoko","family":"Takahashi","sequence":"first","affiliation":[{"name":"From the Department of Occupational Therapy, Kitasato University, Kanagawa, Japan (K.T.); Department of Rehabilitation Medicine, Hyogo College of Medicine, Hyogo, Japan (K.D.); Department of Rehabilitation, Kansai Rehabilitation Hospital, Osaka, Japan (T.S.); Department of Rehabilitation, Tokeidai Memorial Hospital, Hokkaido, Japan (M.T.); Department of Rehabilitation Medicine, Tokyo Bay Rehabilitation Hospital, Chiba, Japan (Y.O.); Department of Neurology, Nagasaki Kita Hospital, Nagasaki, Japan (M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Domen","sequence":"additional","affiliation":[{"name":"From the Department of Occupational Therapy, Kitasato University, Kanagawa, Japan (K.T.); Department of Rehabilitation Medicine, Hyogo College of Medicine, Hyogo, Japan (K.D.); Department of Rehabilitation, Kansai Rehabilitation Hospital, Osaka, Japan (T.S.); Department of Rehabilitation, Tokeidai Memorial Hospital, Hokkaido, Japan (M.T.); Department of Rehabilitation Medicine, Tokyo Bay Rehabilitation Hospital, Chiba, Japan (Y.O.); Department of Neurology, Nagasaki Kita Hospital, Nagasaki, Japan (M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomosaburo","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"From the Department of Occupational Therapy, Kitasato University, Kanagawa, Japan (K.T.); Department of Rehabilitation Medicine, Hyogo College of Medicine, Hyogo, Japan (K.D.); Department of Rehabilitation, Kansai Rehabilitation Hospital, Osaka, Japan (T.S.); Department of Rehabilitation, Tokeidai Memorial Hospital, Hokkaido, Japan (M.T.); Department of Rehabilitation Medicine, Tokyo Bay Rehabilitation Hospital, Chiba, Japan (Y.O.); Department of Neurology, Nagasaki Kita Hospital, Nagasaki, Japan (M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Toshima","sequence":"additional","affiliation":[{"name":"From the Department of Occupational Therapy, Kitasato University, Kanagawa, Japan (K.T.); Department of Rehabilitation Medicine, Hyogo College of Medicine, Hyogo, Japan (K.D.); Department of Rehabilitation, Kansai Rehabilitation Hospital, Osaka, Japan (T.S.); Department of Rehabilitation, Tokeidai Memorial Hospital, Hokkaido, Japan (M.T.); Department of Rehabilitation Medicine, Tokyo Bay Rehabilitation Hospital, Chiba, Japan (Y.O.); Department of Neurology, Nagasaki Kita Hospital, Nagasaki, Japan (M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Otaka","sequence":"additional","affiliation":[{"name":"From the Department of Occupational Therapy, Kitasato University, Kanagawa, Japan (K.T.); Department of Rehabilitation Medicine, Hyogo College of Medicine, Hyogo, Japan (K.D.); Department of Rehabilitation, Kansai Rehabilitation Hospital, Osaka, Japan (T.S.); Department of Rehabilitation, Tokeidai Memorial Hospital, Hokkaido, Japan (M.T.); Department of Rehabilitation Medicine, Tokyo Bay Rehabilitation Hospital, Chiba, Japan (Y.O.); Department of Neurology, Nagasaki Kita Hospital, Nagasaki, Japan (M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Seto","sequence":"additional","affiliation":[{"name":"From the Department of Occupational Therapy, Kitasato University, Kanagawa, Japan (K.T.); Department of Rehabilitation Medicine, Hyogo College of Medicine, Hyogo, Japan (K.D.); Department of Rehabilitation, Kansai Rehabilitation Hospital, Osaka, Japan (T.S.); Department of Rehabilitation, Tokeidai Memorial Hospital, Hokkaido, Japan (M.T.); Department of Rehabilitation Medicine, Tokyo Bay Rehabilitation Hospital, Chiba, Japan (Y.O.); Department of Neurology, Nagasaki Kita Hospital, Nagasaki, Japan (M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsumi","family":"Irie","sequence":"additional","affiliation":[{"name":"From the Department of Occupational Therapy, Kitasato University, Kanagawa, Japan (K.T.); Department of Rehabilitation Medicine, Hyogo College of Medicine, Hyogo, Japan (K.D.); Department of Rehabilitation, Kansai Rehabilitation Hospital, Osaka, Japan (T.S.); Department of Rehabilitation, Tokeidai Memorial Hospital, Hokkaido, Japan (M.T.); Department of Rehabilitation Medicine, Tokyo Bay Rehabilitation Hospital, Chiba, Japan (Y.O.); Department of Neurology, Nagasaki Kita Hospital, Nagasaki, Japan (M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Haga","sequence":"additional","affiliation":[{"name":"From the Department of Occupational Therapy, Kitasato University, Kanagawa, Japan (K.T.); Department of Rehabilitation Medicine, Hyogo College of Medicine, Hyogo, Japan (K.D.); Department of Rehabilitation, Kansai Rehabilitation Hospital, Osaka, Japan (T.S.); Department of Rehabilitation, Tokeidai Memorial Hospital, Hokkaido, Japan (M.T.); Department of Rehabilitation Medicine, Tokyo Bay Rehabilitation Hospital, Chiba, Japan (Y.O.); Department of Neurology, Nagasaki Kita Hospital, Nagasaki, Japan (M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Takebayashi","sequence":"additional","affiliation":[{"name":"From the Department of Occupational Therapy, Kitasato University, Kanagawa, Japan (K.T.); Department of Rehabilitation Medicine, Hyogo College of Medicine, Hyogo, Japan (K.D.); Department of Rehabilitation, Kansai Rehabilitation Hospital, Osaka, Japan (T.S.); Department of Rehabilitation, Tokeidai Memorial Hospital, Hokkaido, Japan (M.T.); Department of Rehabilitation Medicine, Tokyo Bay Rehabilitation Hospital, Chiba, Japan (Y.O.); Department of Neurology, Nagasaki Kita Hospital, Nagasaki, Japan (M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Hachisuka","sequence":"additional","affiliation":[{"name":"From the Department of Occupational Therapy, Kitasato University, Kanagawa, Japan (K.T.); Department of Rehabilitation Medicine, Hyogo College of Medicine, Hyogo, Japan (K.D.); Department of Rehabilitation, Kansai Rehabilitation Hospital, Osaka, Japan (T.S.); Department of Rehabilitation, Tokeidai Memorial Hospital, Hokkaido, Japan (M.T.); Department of Rehabilitation Medicine, Tokyo Bay Rehabilitation Hospital, Chiba, Japan (Y.O.); Department of Neurology, Nagasaki Kita Hospital, Nagasaki, Japan (M..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","unstructured":"World Health Organization. Stroke cerebrovascular accident. Available from: http:\/\/www.emro.who.int\/health-topics\/stroke-cerebrovascular-accident\/index.html. Accessed on November 13 2015."},{"key":"e_1_3_3_3_2","first-page":"504","article-title":"Outpatient rehabilitation among stroke survivors: 21 states and the District of Columbia, 2005.","volume":"56","author":"Centers for Disease Control and Prevention (CDC)","year":"2007","unstructured":"Centers for Disease Control and Prevention (CDC). Outpatient rehabilitation among stroke survivors: 21 states and the District of Columbia, 2005. MMWR Morb Mortal Wkly Rep. 2007;56:504\u2013507.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/128641"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1586\/17434440.2014.882766"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006876.pub3"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1682\/JRRD.2010.10.0210"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1310\/tsr18s01-599"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-140418"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0911341"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.115.012520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:31:19Z","timestamp":1715610679000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.115.012520"}},"subtitle":["An Exploratory Randomized Trial"],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1161\/STROKEAHA.115.012520"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.115.012520","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"2015-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}