{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:26:02Z","timestamp":1775021162135,"version":"3.50.1"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>The aim of this systematic review was to quantify the risk of ipsilateral stroke in patients with asymptomatic carotid artery occlusion (ACAO).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>\n              Studies reporting ipsilateral stroke risk in ACAO were identified by a search of MEDLINE, EMBASE, and study bibliographies. Study estimates were pooled using a random effects model, and heterogeneity was quantified using the\n              <jats:italic>I<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              statistic. The primary outcome was the annual rate of ipsilateral stroke.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Thirteen studies were identified, encompassing 718 patients with ACAO who were followed up for a median of 2.8 years. The annual rate of ipsilateral stroke was 1.3% (95% confidence interval, 0.4\u20132.1;\n              <jats:italic>I<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =53%). The annual rate of ipsilateral transient ischemic attack was 1.0% (95% confidence interval, 0.3\u20131.8;\n              <jats:italic>I<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =40%). The annual rate of death was substantially higher at 7.7% (95% confidence interval, 4.3\u201311.2;\n              <jats:italic>I<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\n              =83%). Correction for possible publication bias for the primary outcome suggested a lower risk of ipsilateral stroke (0.3% per year; 95% confidence interval, \u20130.4 to 1.1).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Stroke in ACAO is relatively infrequent, but patients face high mortality rates. This suggests the need for intensified medical therapy in ACAO.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.116.012760","type":"journal-article","created":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T03:37:50Z","timestamp":1460518670000},"page":"1253-1257","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Prognosis of Asymptomatic Carotid Artery Occlusion"],"prefix":"10.1161","volume":"47","author":[{"given":"Daniel G.","family":"Hackam","sequence":"first","affiliation":[{"name":"From the Division of Clinical Pharmacology, Departments of Medicine and Clinical Neurological Sciences and Stroke Prevention and Atherosclerosis Research Centre (SPARC), Robarts Research Institute, Western University, London, Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-011-0145-6"},{"key":"e_1_3_3_3_2","first-page":"2002","article-title":"Aetiologies, clinical and vascular findings in symptomatic and asymptomatic carotid artery occlusion.","volume":"153","author":"Baumann T","year":"2002","unstructured":"Baumann T, Steck AJ, Lyrer P. Aetiologies, clinical and vascular findings in symptomatic and asymptomatic carotid artery occlusion. Schweiz Arch Neurol Psychiatr. 2002;153:2002.","journal-title":"Schweiz Arch Neurol Psychiatr"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1052-3057(10)80162-4"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.1.6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.4.718"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.4.878"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.03.010"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-2-23"},{"key":"e_1_3_3_11_2","unstructured":"Wells G Shea B O\u2019Connell D Peterson J Welch V Losos M Tugwell P. 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