{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:20:08Z","timestamp":1760955608489},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2016,6]]},"abstract":"\n Background and Purpose\u2014<\/jats:title>\n Impaired cerebrovascular reserve in chronic steno-occlusive disease has been shown to be associated with poor leptomeningeal collaterals (LMCs) on digital subtraction angiography and increased stroke risk. We examined the relationship between the degree of LMCs and the flow change with Diamox challenge measured using quantitative magnetic resonance angiography (QMRA).<\/jats:p>\n <\/jats:sec>\n \n Methods\u2014<\/jats:title>\n \n Patients with steno-occlusion in the internal carotid artery or middle cerebral artery (MCA) at our institution between 2007 and 2013 were retrospectively studied. Intracranial flows were obtained using QMRA, and flow change with Diamox (QMRA\n \u0394d<\/jats:sub>\n ) was calculated as follows: ([flow after Diamox\u2212flow before Diamox]\/[flow before Diamox])\u00d7100%. Poor LMC was defined as grade 1 or 2, and robust LMC was defined as grade 3 or 4 based on the ASITN\/SIR (American Society of Interventional and Therapeutic Neuroradiology\/Society of Interventional Radiology) grading system on digital subtraction angiography.\n <\/jats:p>\n <\/jats:sec>\n \n Results\u2014<\/jats:title>\n \n Thirty-eight patients had angiographic and flow data. Ipsilateral MCA QMRA\n \u0394d<\/jats:sub>\n was significantly lower versus the contralateral side (flow, 85.5 versus 135.9 mL\/min;\n P<\/jats:italic>\n <0.001 and QMRA\n \u0394d<\/jats:sub>\n , 24.0% versus 45.6%;\n P<\/jats:italic>\n =0.01). If LMCs were robust (n=12), MCA QMRA\n \u0394d<\/jats:sub>\n was significantly higher (21.4% versus \u221226.8%;\n P<\/jats:italic>\n =0.04) compared with patients with poor LMC (n=4).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions\u2014<\/jats:title>\n \n We show that patients with more robust LMC have better MCA QMRA\n \u0394d<\/jats:sub>\n . Therefore, QMRA\n \u0394d<\/jats:sub>\n may be used for the functional assessment of LMC as a surrogate for cerebrovascular reserve in chronic internal carotid artery or MCA steno-occlusive disease.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/strokeaha.116.013015","type":"journal-article","created":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T04:19:25Z","timestamp":1461125965000},"page":"1658-1660","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Angiographic Correlates of Cerebral Hemodynamic Changes With Diamox Challenge Assessed by Quantitative Magnetic Resonance Angiography"],"prefix":"10.1161","volume":"47","author":[{"given":"Mersedeh","family":"Bahr-Hosseini","sequence":"first","affiliation":[{"name":"From the Departments of Neurology (M.B.-H.) and Neurosurgery (S.F.S., S.A.-H., F.T.C., A.A.), University of Illinois at Chicago."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia F.","family":"Shakur","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (M.B.-H.) and Neurosurgery (S.F.S., S.A.-H., F.T.C., A.A.), University of Illinois at Chicago."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sepideh","family":"Amin-Hanjani","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (M.B.-H.) and Neurosurgery (S.F.S., S.A.-H., F.T.C., A.A.), University of Illinois at Chicago."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fady T.","family":"Charbel","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (M.B.-H.) and Neurosurgery (S.F.S., S.A.-H., F.T.C., A.A.), University of Illinois at Chicago."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Alaraj","sequence":"additional","affiliation":[{"name":"From the Departments of Neurology (M.B.-H.) and Neurosurgery (S.F.S., S.A.-H., F.T.C., A.A.), University of Illinois at Chicago."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40134-013-0029-5"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.224"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1538"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2014.03.001"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000618"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108153250701"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043033"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22354"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2794"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000063719"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.2.296"},{"key":"e_1_3_3_13_2","first-page":"928","article-title":"Correlation of cerebrovascular reserve as measured by acetazolamide-challenged SPECT with angiographic flow patterns and intra- or extracranial arterial stenosis.","volume":"22","author":"Ozgur HT","year":"2001","unstructured":"Ozgur HT, Kent Walsh T, Masaryk A, Seeger JF, Williams W, Krupinski E, et al.. Correlation of cerebrovascular reserve as measured by acetazolamide-challenged SPECT with angiographic flow patterns and intra- or extracranial arterial stenosis. AJNR Am J Neuroradiol. 2001;22:928\u2013936.","journal-title":"AJNR Am J Neuroradiol"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.116.013015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:37:17Z","timestamp":1715611037000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.116.013015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1161\/STROKEAHA.116.013015"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.116.013015","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"2016-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}