{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T21:20:39Z","timestamp":1787952039469,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>\n                      There is some uncertainty about treating patients with atrial fibrillation (AF) with 1 nongender-related (NGR) stroke risk factor (CHA\n                      <jats:sub>2<\/jats:sub>\n                      DS\n                      <jats:sub>2<\/jats:sub>\n                      -VASc [ie, congestive heart failure, hypertension, age (\u226575 years; 2 points), diabetes, stroke\/transient ischemic attack (2 points), vascular disease, age (65\u201374 years), sex (female)] score of 1 in males and 2 in females) with oral anticoagulation (OAC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>\n                      We investigated adverse outcomes and calculated the net clinical benefit of OAC use in a community-based cohort of unselected AF patients with 0 compared with 1 NGR stroke risk factor (CHA\n                      <jats:sub>2<\/jats:sub>\n                      DS\n                      <jats:sub>2<\/jats:sub>\n                      -VASc 0 versus 1 in males; and 1 versus 2 in females). Among 8962 patients with AF, 2208 (25%) had 0 or 1 NGR stroke risk factors, of which 45% were not prescribed OAC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>During a follow-up of 1028\u00b11189 days (median, 495; interquartile range, 5\u20131882 days), the yearly rate of the combined end point of stroke\/systemic embolism in nonanticoagulated AF patients with 1 NGR stroke risk factor was 2.09% (95% confidence interval, 1.37\u20133.18). This corresponded to an adjusted hazard ratio of 2.82 (95% confidence interval, 1.32\u20136.04) relative to the group with 0 NGR stroke risk factor. When the benefit of ischemic stroke reduction was balanced against the increased risk of intracranial hemorrhage among patients with 1 NGR stroke risk factor, the net clinical benefit was positive in favor of OAC use versus no antithrombotic therapy or antiplatelet therapy use. The net clinical benefit was negative for antiplatelet therapy use versus no antithrombotic therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>\n                      Among AF patients with 1 NGR stroke risk factor (ie, CHA\n                      <jats:sub>2<\/jats:sub>\n                      DS\n                      <jats:sub>2<\/jats:sub>\n                      -VASc 1 in males or 2 in females), OAC use as indicated according to the guidelines was associated with a positive net clinical benefit for the prevention of stroke and thromboembolic events.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.116.013253","type":"journal-article","created":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T00:14:14Z","timestamp":1464308054000},"page":"1831-1836","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":62,"title":["Should Atrial Fibrillation Patients With Only 1 Nongender-Related CHA\n                    <sub>2<\/sub>\n                    DS\n                    <sub>2<\/sub>\n                    -VASc Risk Factor Be Anticoagulated?"],"prefix":"10.1161","volume":"47","author":[{"given":"Laurent","family":"Fauchier","sequence":"first","affiliation":[{"name":"From the Service de Cardiologie, Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine, Universit\u00e9 Fran\u00e7ois Rabelais, Tours, France (L.F., N.C., A.B., F.I., D.A., D.B.); University of Birmingham Institute of Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom (G.Y.H.L.); and Department of Clinical Medicine, Aalborg Thrombosis Research Unit, Aalborg University, Aalborg, Denmark (G.Y.H.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Clementy","sequence":"additional","affiliation":[{"name":"From the Service de Cardiologie, Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine, Universit\u00e9 Fran\u00e7ois Rabelais, Tours, France (L.F., N.C., A.B., F.I., D.A., D.B.); University of Birmingham Institute of Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom (G.Y.H.L.); and Department of Clinical Medicine, Aalborg Thrombosis Research Unit, Aalborg University, Aalborg, Denmark (G.Y.H.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Bisson","sequence":"additional","affiliation":[{"name":"From the Service de Cardiologie, Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine, Universit\u00e9 Fran\u00e7ois Rabelais, Tours, France (L.F., N.C., A.B., F.I., D.A., D.B.); University of Birmingham Institute of Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom (G.Y.H.L.); and Department of Clinical Medicine, Aalborg Thrombosis Research Unit, Aalborg University, Aalborg, Denmark (G.Y.H.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Ivanes","sequence":"additional","affiliation":[{"name":"From the Service de Cardiologie, Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine, Universit\u00e9 Fran\u00e7ois Rabelais, Tours, France (L.F., N.C., A.B., F.I., D.A., D.B.); University of Birmingham Institute of Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom (G.Y.H.L.); and Department of Clinical Medicine, Aalborg Thrombosis Research Unit, Aalborg University, Aalborg, Denmark (G.Y.H.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Angoulvant","sequence":"additional","affiliation":[{"name":"From the Service de Cardiologie, Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine, Universit\u00e9 Fran\u00e7ois Rabelais, Tours, France (L.F., N.C., A.B., F.I., D.A., D.B.); University of Birmingham Institute of Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom (G.Y.H.L.); and Department of Clinical Medicine, Aalborg Thrombosis Research Unit, Aalborg University, Aalborg, Denmark (G.Y.H.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Babuty","sequence":"additional","affiliation":[{"name":"From the Service de Cardiologie, Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine, Universit\u00e9 Fran\u00e7ois Rabelais, Tours, France (L.F., N.C., A.B., F.I., D.A., D.B.); University of Birmingham Institute of Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom (G.Y.H.L.); and Department of Clinical Medicine, Aalborg Thrombosis Research Unit, Aalborg University, Aalborg, Denmark (G.Y.H.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y.H.","family":"Lip","sequence":"additional","affiliation":[{"name":"From the Service de Cardiologie, Centre Hospitalier Universitaire Trousseau et Facult\u00e9 de M\u00e9decine, Universit\u00e9 Fran\u00e7ois Rabelais, Tours, France (L.F., N.C., A.B., F.I., D.A., D.B.); University of Birmingham Institute of Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom (G.Y.H.L.); and Department of Clinical Medicine, Aalborg Thrombosis Research Unit, Aalborg University, Aalborg, Denmark (G.Y.H.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-12-200706190-00007"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1584"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs253"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.022"},{"key":"e_1_3_2_6_2","unstructured":"National Clinical Guideline Centre (UK). Atrial Fibrillation: The Management of Atrial Fibrillation [Internet]. London United Kingdom: National Institute for Health and Care Excellence (UK); 2014. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK248059\/. 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