{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:37:27Z","timestamp":1780627047543,"version":"3.54.1"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Early anticoagulation after cardioembolic stroke remains controversial because of the potential for hemorrhagic transformation (HT). We tested the safety and feasibility of initiating rivaroxaban \u226414 days after cardioembolic stroke\/transient ischemic attack.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>A prospective, open-label study of patients with atrial fibrillation treated with rivaroxaban \u226414 days of transient ischemic attack or ischemic stroke (National Institute of Health Stroke Scale &lt;9). All patients underwent magnetic resonance imaging &lt;24 hours of rivaroxaban initiation and day 7. The primary end point was symptomatic HT at day 7.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>Sixty patients (mean\u00b1SD age 71\u00b119 years, 82% stroke\/18% transient ischemic attack) were enrolled. Median (interquartile range) time from onset to rivaroxaban was 3 (5) days. At treatment initiation, median National Institute of Health Stroke Scale was 2 (4), and median diffusion-weighted imaging volume was 7.9 (13.7) mL. At baseline, HT was present in 25 (42%) patients (hemorrhagic infarct [HI]1=19, HI2=6). On follow-up magnetic resonance imaging, no patients developed symptomatic HT. New asymptomatic HI1 developed in 3 patients, and asymptomatic progression from HI1 to HI2 occurred in 5 patients; otherwise, HT remained unchanged at day 7.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>These data support the safety of rivaroxaban initiation \u226414 days of mild\u2013moderate cardioembolic stroke\/transient ischemic attack. Magnetic resonance imaging evidence of petechial HT, which is common, does not appear to increase the risk of symptomatic HT.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.116.013491","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T03:51:00Z","timestamp":1464148260000},"page":"1917-1919","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":54,"title":["Early Rivaroxaban Use After Cardioembolic Stroke May Not Result in Hemorrhagic Transformation"],"prefix":"10.1161","volume":"47","author":[{"given":"Laura C.","family":"Gioia","sequence":"first","affiliation":[{"name":"From the Division of Neurology, University of Montreal, Montreal, Canada (L.C.G.); and Division of Neurology (M.K., L.S., D.H., H.K., B.B., M.B., T.J., A.S., K.B.), and Department of Diagnostic Imaging (D.E.), University of Alberta, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Kate","sequence":"additional","affiliation":[{"name":"From the Division of Neurology, University of Montreal, Montreal, Canada (L.C.G.); and Division of Neurology (M.K., L.S., D.H., H.K., B.B., M.B., T.J., A.S., K.B.), and Department of Diagnostic Imaging (D.E.), University of Alberta, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leka","family":"Sivakumar","sequence":"additional","affiliation":[{"name":"From the Division of Neurology, University of Montreal, Montreal, Canada (L.C.G.); and Division of Neurology (M.K., L.S., D.H., H.K., B.B., M.B., T.J., A.S., K.B.), and Department of Diagnostic Imaging (D.E.), University of Alberta, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dulara","family":"Hussain","sequence":"additional","affiliation":[{"name":"From the Division of Neurology, University of Montreal, Montreal, Canada (L.C.G.); and Division of Neurology (M.K., L.S., D.H., H.K., B.B., M.B., T.J., A.S., K.B.), and Department of Diagnostic Imaging (D.E.), University of Alberta, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayrapet","family":"Kalashyan","sequence":"additional","affiliation":[{"name":"From the Division of Neurology, University of Montreal, Montreal, Canada (L.C.G.); and Division of Neurology (M.K., L.S., D.H., H.K., B.B., M.B., T.J., A.S., K.B.), and Department of Diagnostic Imaging (D.E.), University of Alberta, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Buck","sequence":"additional","affiliation":[{"name":"From the Division of Neurology, University of Montreal, Montreal, Canada (L.C.G.); and Division of Neurology (M.K., L.S., D.H., H.K., B.B., M.B., T.J., A.S., K.B.), and Department of Diagnostic Imaging (D.E.), University of Alberta, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Bussiere","sequence":"additional","affiliation":[{"name":"From the Division of Neurology, University of Montreal, Montreal, Canada (L.C.G.); and Division of Neurology (M.K., L.S., D.H., H.K., B.B., M.B., T.J., A.S., K.B.), and Department of Diagnostic Imaging (D.E.), University of Alberta, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Jeerakathil","sequence":"additional","affiliation":[{"name":"From the Division of Neurology, University of Montreal, Montreal, Canada (L.C.G.); and Division of Neurology (M.K., L.S., D.H., H.K., B.B., M.B., T.J., A.S., K.B.), and Department of Diagnostic Imaging (D.E.), University of Alberta, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashfaq","family":"Shuaib","sequence":"additional","affiliation":[{"name":"From the Division of Neurology, University of Montreal, Montreal, Canada (L.C.G.); and Division of Neurology (M.K., L.S., D.H., H.K., B.B., M.B., T.J., A.S., K.B.), and Department of Diagnostic Imaging (D.E.), University of Alberta, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Emery","sequence":"additional","affiliation":[{"name":"From the Division of Neurology, University of Montreal, Montreal, Canada (L.C.G.); and Division of Neurology (M.K., L.S., D.H., H.K., B.B., M.B., T.J., A.S., K.B.), and Department of Diagnostic Imaging (D.E.), University of Alberta, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Butcher","sequence":"additional","affiliation":[{"name":"From the Division of Neurology, University of Montreal, Montreal, Canada (L.C.G.); and Division of Neurology (M.K., L.S., D.H., H.K., B.B., M.B., T.J., A.S., K.B.), and Department of Diagnostic Imaging (D.E.), University of Alberta, Alberta, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000024.pub4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-03-0228"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009638"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.11.2280"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.7.1770"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2217\/fnl.15.43"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijs.12452"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.6.1198"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.116.013491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:34:21Z","timestamp":1715610861000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.116.013491"}},"subtitle":["A Prospective Magnetic Resonance Imaging Study"],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":8,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1161\/STROKEAHA.116.013491"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.116.013491","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"2016-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}